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2015


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Quantifying changes in climate variability and extremes: Pitfalls and their overcoming

Sippel, S., Zscheischler, J., Heimann, M., Otto, F. E. L., Peters, J., Mahecha, M. D.

Geophysical Research Letters, 42(22):9990-9998, November 2015 (article)

ei

DOI [BibTex]

2015


DOI [BibTex]


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Diversity of sharp wave-ripple LFP signatures reveals differentiated brain-wide dynamical events

Ramirez-Villegas, J. F., Logothetis, N. K., Besserve, M.

Proceedings of the National Academy of Sciences U.S.A, 112(46):E6379-E6387, November 2015 (article)

ei

DOI [BibTex]

DOI [BibTex]


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Noise masking of White’s illusion exposes the weakness of current spatial filtering models of lightness perception

Betz, T., Shapley, R. M., Wichmann, F. A., Maertens, M.

Journal of Vision, 15(14):1-17, October 2015 (article)

ei

DOI [BibTex]

DOI [BibTex]


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Shifts of Gamma Phase across Primary Visual Cortical Sites Reflect Dynamic Stimulus-Modulated Information Transfer

Besserve, M., Lowe, S. C., Logothetis, N. K., Schölkopf, B., Panzeri, S.

PLOS Biology, 13(9):e1002257, September 2015 (article)

ei

DOI [BibTex]

DOI [BibTex]


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Semi-Supervised Interpolation in an Anticausal Learning Scenario

Janzing, D., Schölkopf, B.

Journal of Machine Learning Research, 16, pages: 1923-1948, September 2015 (article)

ei

link (url) [BibTex]

link (url) [BibTex]


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Testing the role of luminance edges in White’s illusion with contour adaptation

Betz, T., Shapley, R. M., Wichmann, F. A., Maertens, M.

Journal of Vision, 15(11):1-16, August 2015 (article)

ei

DOI [BibTex]

DOI [BibTex]


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Blind multirigid retrospective motion correction of MR images

Loktyushin, A., Nickisch, H., Pohmann, R., Schölkopf, B.

Magnetic Resonance in Medicine, 73(4):1457-1468, April 2015 (article)

ei

DOI [BibTex]

DOI [BibTex]


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A quantum advantage for inferring causal structure

Ried, K., Agnew, M., Vermeyden, L., Janzing, D., Spekkens, R. W., Resch, K. J.

Nature Physics, 11(5):414-420, March 2015 (article)

Abstract
The problem of inferring causal relations from observed correlations is relevant to a wide variety of scientific disciplines. Yet given the correlations between just two classical variables, it is impossible to determine whether they arose from a causal influence of one on the other or a common cause influencing both. Only a randomized trial can settle the issue. Here we consider the problem of causal inference for quantum variables. We show that the analogue of a randomized trial, causal tomography, yields a complete solution. We also show that, in contrast to the classical case, one can sometimes infer the causal structure from observations alone. We implement a quantum-optical experiment wherein we control the causal relation between two optical modes, and two measurement schemes—with and without randomization—that extract this relation from the observed correlations. Our results show that entanglement and quantum coherence provide an advantage for causal inference.

ei

DOI [BibTex]

DOI [BibTex]


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Positive definite matrices and the S-divergence

Sra, S.

Proceedings of the American Mathematical Society, 2015, Published electronically: October 22, 2015 (article)

ei

DOI [BibTex]

DOI [BibTex]


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Structural Intervention Distance (SID) for Evaluating Causal Graphs

Peters, J., Bühlmann, P.

Neural Computation , 27(3):771-799, 2015 (article)

ei

DOI [BibTex]

DOI [BibTex]


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Likelihood and Consilience: On Forster’s Counterexamples to the Likelihood Theory of Evidence

Zhang, J., Zhang, K.

Philosophy of Science, Supplementary Volume 2015, 82(5):930-940, 2015 (article)

ei

DOI [BibTex]

DOI [BibTex]


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Crowdsourced analysis of clinical trial data to predict amyotrophic lateral sclerosis progression

Küffner, R., Zach, N., Norel, R., Hawe, J., Schoenfeld, D., Wang, L., Li, G., Fang, L., Mackey, L., Hardiman, O., Cudkowicz, M., Sherman, A., Ertaylan, G., Grosse-Wentrup, M., Hothorn, T., van Ligtenberg, J., Macke, J., Meyer, T., Schölkopf, B., Tran, L., Vaughan, R., Stolovitzky, G., Leitner, M.

Nature Biotechnology, 33, pages: 51-57, 2015 (article)

ei

DOI [BibTex]

DOI [BibTex]


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Probabilistic Interpretation of Linear Solvers

Hennig, P.

SIAM Journal on Optimization, 25(1):234-260, 2015 (article)

ei pn

Web PDF link (url) DOI [BibTex]

Web PDF link (url) DOI [BibTex]


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Developing biorobotics for veterinary research into cat movements

Mariti, C., Muscolo, G., Peters, J., Puig, D., Recchiuto, C., Sighieri, C., Solanas, A., von Stryk, O.

Journal of Veterinary Behavior: Clinical Applications and Research, 10(3):248-254, 2015 (article)

ei

DOI [BibTex]

DOI [BibTex]


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Spatial statistics and attentional dynamics in scene viewing

Engbert, R., Trukenbrod, H., Barthelmé, S., Wichmann, F.

Journal of Vision, 15(1):1-17, 2015 (article)

ei

Web PDF link (url) DOI [BibTex]

Web PDF link (url) DOI [BibTex]


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The Randomized Causation Coefficient

Lopez-Paz, D., Muandet, K., Recht, B.

Journal of Machine Learning, 16, pages: 2901-2907, 2015 (article)

ei

link (url) [BibTex]

link (url) [BibTex]


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Towards denoising XMCD movies of fast magnetization dynamics using extended Kalman filter

Kopp, M., Harmeling, S., Schütz, G., Schölkopf, B., Fähnle, M.

Ultramicroscopy, 148, pages: 115-122, 2015 (article)

Abstract
The Kalman filter is a well-established approach to get information on the time-dependent state of a system from noisy observations. It was developed in the context of the Apollo project to see the deviation of the true trajectory of a rocket from the desired trajectory. Afterwards it was applied to many different systems with small numbers of components of the respective state vector (typically about 10). In all cases the equation of motion for the state vector was known exactly. The fast dissipative magnetization dynamics is often investigated by x-ray magnetic circular dichroism movies (XMCD movies), which are often very noisy. In this situation the number of components of the state vector is extremely large (about 105), and the equation of motion for the dissipative magnetization dynamics (especially the values of the material parameters of this equation) is not well known. In the present paper it is shown by theoretical considerations that – nevertheless – there is no principle problem for the use of the Kalman filter to denoise XMCD movies of fast dissipative magnetization dynamics.

ei

Web DOI [BibTex]

Web DOI [BibTex]


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Artificial intelligence: Learning to see and act

Schölkopf, B.

Nature, News & Views, 518(7540):486-487, 2015 (article)

ei

DOI [BibTex]

DOI [BibTex]


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Context affects lightness at the level of surfaces

Maertens, M., Wichmann, F., Shapley, R.

Journal of Vision, 15(1):1-15, 2015 (article)

ei

Web PDF link (url) DOI [BibTex]

Web PDF link (url) DOI [BibTex]


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Genome-wide analysis of local chromatin packing in Arabidopsis thaliana

Wang, C., Liu, C., Roqueiro, D., Grimm, D., Schwab, R., Becker, C., Lanz, C., Weigel, D.

Genome Research, 25(2):246-256, 2015 (article)

ei

PDF DOI [BibTex]

PDF DOI [BibTex]


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Segmentation-based attenuation correction in positron emission tomography/magnetic resonance: erroneous tissue identification and its impact on positron emission tomography interpretation

Brendle, C., Schmidt, H., Oergel, A., Bezrukov, I., Mueller, M., Schraml, C., Pfannenberg, C., la Fougère, C., Nikolaou, K., Schwenzer, N.

Investigative Radiology, 50(5):339-346, 2015 (article)

ei

DOI [BibTex]

DOI [BibTex]


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Active Reward Learning with a Novel Acquisition Function

Daniel, C., Kroemer, O., Viering, M., Metz, J., Peters, J.

Autonomous Robots, 39(3):389-405, 2015 (article)

am ei

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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A systematic search for transiting planets in the K2 data

Foreman-Mackey, D., Montet, B., Hogg, D., Morton, T., Wang, D., Schölkopf, B.

The Astrophysical Journal, 806(2), 2015 (article)

Abstract
Photometry of stars from the K2 extension of NASA’s Kepler mission is afflicted by systematic effects caused by small (few-pixel) drifts in the telescope pointing and other spacecraft issues. We present a method for searching K2 light curves for evidence of exoplanets by simultaneously fitting for these systematics and the transit signals of interest. This method is more computationally expensive than standard search algorithms but we demonstrate that it can be efficiently implemented and used to discover transit signals. We apply this method to the full Campaign 1 data set and report a list of 36 planet candidates transiting 31 stars, along with an analysis of the pipeline performance and detection efficiency based on artificial signal injections and recoveries. For all planet candidates, we present posterior distributions on the properties of each system based strictly on the transit observables.

ei

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Learning Movement Primitive Attractor Goals and Sequential Skills from Kinesthetic Demonstrations

Manschitz, S., Kober, J., Gienger, M., Peters, J.

Robotics and Autonomous Systems, 74, Part A, pages: 97-107, 2015 (article)

am ei

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Bayesian Optimization for Learning Gaits under Uncertainty

Calandra, R., Seyfarth, A., Peters, J., Deisenroth, M.

Annals of Mathematics and Artificial Intelligence, pages: 1-19, 2015 (article)

am ei

DOI [BibTex]

DOI [BibTex]


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Assessment of murine brain tissue shrinkage caused by different histological fixatives using magnetic resonance and computed tomography imaging

Wehrl, H. F., Bezrukov, I., Wiehr, S., Lehnhoff, M., Fuchs, K., Mannheim, J. G., Quintanilla-Martinez, L., Kneilling, M., Pichler, B. J., Sauter, A. W.

Histology and Histopathology, 30(5):601-613, 2015 (article)

ei

[BibTex]

[BibTex]


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Improved Bayesian Information Criterion for Mixture Model Selection

Mehrjou, A., Hosseini, R., Araabi, B.

Pattern Recognition Letters, 69, pages: 22-27, 2015 (article)

ei

DOI [BibTex]

DOI [BibTex]


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Correlation matrix nearness and completion under observation uncertainty

Alaíz, C. M., Dinuzzo, F., Sra, S.

IMA Journal of Numerical Analysis, 35(1):325-340, 2015 (article)

ei

DOI [BibTex]

DOI [BibTex]


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Quantitative evaluation of segmentation- and atlas- based attenuation correction for PET/MR on pediatric patients

Bezrukov, I., Schmidt, H., Gatidis, S., Mantlik, F., Schäfer, J. F., Schwenzer, N., Pichler, B. J.

Journal of Nuclear Medicine, 56(7):1067-1074, 2015 (article)

ei

DOI [BibTex]

DOI [BibTex]


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Probabilistic numerics and uncertainty in computations

Hennig, P., Osborne, M. A., Girolami, M.

Proceedings of the Royal Society of London A: Mathematical, Physical and Engineering Sciences, 471(2179), 2015 (article)

Abstract
We deliver a call to arms for probabilistic numerical methods: algorithms for numerical tasks, including linear algebra, integration, optimization and solving differential equations, that return uncertainties in their calculations. Such uncertainties, arising from the loss of precision induced by numerical calculation with limited time or hardware, are important for much contemporary science and industry. Within applications such as climate science and astrophysics, the need to make decisions on the basis of computations with large and complex data have led to a renewed focus on the management of numerical uncertainty. We describe how several seminal classic numerical methods can be interpreted naturally as probabilistic inference. We then show that the probabilistic view suggests new algorithms that can flexibly be adapted to suit application specifics, while delivering improved empirical performance. We provide concrete illustrations of the benefits of probabilistic numeric algorithms on real scientific problems from astrometry and astronomical imaging, while highlighting open problems with these new algorithms. Finally, we describe how probabilistic numerical methods provide a coherent framework for identifying the uncertainty in calculations performed with a combination of numerical algorithms (e.g. both numerical optimizers and differential equation solvers), potentially allowing the diagnosis (and control) of error sources in computations.

ei pn

PDF DOI [BibTex]

PDF DOI [BibTex]


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Mass and galaxy distributions of four massive galaxy clusters from Dark Energy Survey Science Verification data

Melchior, P., Suchyta, E., Huff, E., Hirsch, M., Kacprzak, T., Rykoff, E., Gruen, D., Armstrong, R., Bacon, D., Bechtol, K., others,

Monthly Notices of the Royal Astronomical Society, 449(3):2219-2238, Oxford University Press, 2015 (article)

ei

DOI [BibTex]

DOI [BibTex]


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Kinematic and gait similarities between crawling human infants and other quadruped mammals

Righetti, L., Nylen, A., Rosander, K., Ijspeert, A.

Frontiers in Neurology, 6(17), February 2015 (article)

Abstract
Crawling on hands and knees is an early pattern of human infant locomotion, which offers an interesting way of studying quadrupedalism in one of its simplest form. We investigate how crawling human infants compare to other quadruped mammals, especially primates. We present quantitative data on both the gait and kinematics of seven 10-month-old crawling infants. Body movements were measured with an optoelectronic system giving precise data on 3-dimensional limb movements. Crawling on hands and knees is very similar to the locomotion of non-human primates in terms of the quite protracted arm at touch-down, the coordination between the spine movements in the lateral plane and the limbs, the relatively extended limbs during locomotion and the strong correlation between stance duration and speed of locomotion. However, there are important differences compared to primates, such as the choice of a lateral-sequence walking gait, which is similar to most non-primate mammals and the relatively stiff elbows during stance as opposed to the quite compliant gaits of primates. These finding raise the question of the role of both the mechanical structure of the body and neural control on the determination of these characteristics.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Entropic Movement Complexity Reflects Subjective Creativity Rankings of Visualized Hand Motion Trajectories

Peng, Z, Braun, DA

Frontiers in Psychology, 6(1879):1-13, December 2015 (article)

Abstract
In a previous study we have shown that human motion trajectories can be characterized by translating continuous trajectories into symbol sequences with well-defined complexity measures. Here we test the hypothesis that the motion complexity individuals generate in their movements might be correlated to the degree of creativity assigned by a human observer to the visualized motion trajectories. We asked participants to generate 55 novel hand movement patterns in virtual reality, where each pattern had to be repeated 10 times in a row to ensure reproducibility. This allowed us to estimate a probability distribution over trajectories for each pattern. We assessed motion complexity not only by the previously proposed complexity measures on symbolic sequences, but we also propose two novel complexity measures that can be directly applied to the distributions over trajectories based on the frameworks of Gaussian Processes and Probabilistic Movement Primitives. In contrast to previous studies, these new methods allow computing complexities of individual motion patterns from very few sample trajectories. We compared the different complexity measures to how a group of independent jurors rank ordered the recorded motion trajectories according to their personal creativity judgment. We found three entropic complexity measures that correlate significantly with human creativity judgment and discuss differences between the measures. We also test whether these complexity measures correlate with individual creativity in divergent thinking tasks, but do not find any consistent correlation. Our results suggest that entropic complexity measures of hand motion may reveal domain-specific individual differences in kinesthetic creativity.

ei

DOI [BibTex]

DOI [BibTex]


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Bounded rationality, abstraction and hierarchical decision-making: an information-theoretic optimality principle

Genewein, T, Leibfried, F, Grau-Moya, J, Braun, DA

Frontiers in Robotics and AI, 2(27):1-24, October 2015 (article)

Abstract
Abstraction and hierarchical information-processing are hallmarks of human and animal intelligence underlying the unrivaled flexibility of behavior in biological systems. Achieving such a flexibility in artificial systems is challenging, even with more and more computational power. Here we investigate the hypothesis that abstraction and hierarchical information-processing might in fact be the consequence of limitations in information-processing power. In particular, we study an information-theoretic framework of bounded rational decision-making that trades off utility maximization against information-processing costs. We apply the basic principle of this framework to perception-action systems with multiple information-processing nodes and derive bounded optimal solutions. We show how the formation of abstractions and decision-making hierarchies depends on information-processing costs. We illustrate the theoretical ideas with example simulations and conclude by formalizing a mathematically unifying optimization principle that could potentially be extended to more complex systems.

ei

DOI [BibTex]

DOI [BibTex]


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Signaling equilibria in sensorimotor interactions

Leibfried, F, Grau-Moya, J, Braun, DA

Cognition, 141, pages: 73-86, August 2015 (article)

Abstract
Although complex forms of communication like human language are often assumed to have evolved out of more simple forms of sensorimotor signaling, less attention has been devoted to investigate the latter. Here, we study communicative sensorimotor behavior of humans in a two-person joint motor task where each player controls one dimension of a planar motion. We designed this joint task as a game where one player (the sender) possesses private information about a hidden target the other player (the receiver) wants to know about, and where the sender's actions are costly signals that influence the receiver's control strategy. We developed a game-theoretic model within the framework of signaling games to investigate whether subjects' behavior could be adequately described by the corresponding equilibrium solutions. The model predicts both separating and pooling equilibria, in which signaling does and does not occur respectively. We observed both kinds of equilibria in subjects and found that, in line with model predictions, the propensity of signaling decreased with increasing signaling costs and decreasing uncertainty on the part of the receiver. Our study demonstrates that signaling games, which have previously been applied to economic decision-making and animal communication, provide a framework for human signaling behavior arising during sensorimotor interactions in continuous and dynamic environments.

ei

DOI [BibTex]

DOI [BibTex]


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Structure Learning in Bayesian Sensorimotor Integration

Genewein, T, Hez, E, Razzaghpanah, Z, Braun, DA

PLoS Computational Biology, 11(8):1-27, August 2015 (article)

Abstract
Previous studies have shown that sensorimotor processing can often be described by Bayesian learning, in particular the integration of prior and feedback information depending on its degree of reliability. Here we test the hypothesis that the integration process itself can be tuned to the statistical structure of the environment. We exposed human participants to a reaching task in a three-dimensional virtual reality environment where we could displace the visual feedback of their hand position in a two dimensional plane. When introducing statistical structure between the two dimensions of the displacement, we found that over the course of several days participants adapted their feedback integration process in order to exploit this structure for performance improvement. In control experiments we found that this adaptation process critically depended on performance feedback and could not be induced by verbal instructions. Our results suggest that structural learning is an important meta-learning component of Bayesian sensorimotor integration.

ei

DOI [BibTex]

DOI [BibTex]


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A Reward-Maximizing Spiking Neuron as a Bounded Rational Decision Maker

Leibfried, F, Braun, DA

Neural Computation, 27(8):1686-1720, July 2015 (article)

Abstract
Rate distortion theory describes how to communicate relevant information most efficiently over a channel with limited capacity. One of the many applications of rate distortion theory is bounded rational decision making, where decision makers are modeled as information channels that transform sensory input into motor output under the constraint that their channel capacity is limited. Such a bounded rational decision maker can be thought to optimize an objective function that trades off the decision maker's utility or cumulative reward against the information processing cost measured by the mutual information between sensory input and motor output. In this study, we interpret a spiking neuron as a bounded rational decision maker that aims to maximize its expected reward under the computational constraint that the mutual information between the neuron's input and output is upper bounded. This abstract computational constraint translates into a penalization of the deviation between the neuron's instantaneous and average firing behavior. We derive a synaptic weight update rule for such a rate distortion optimizing neuron and show in simulations that the neuron efficiently extracts reward-relevant information from the input by trading off its synaptic strengths against the collected reward.

ei

DOI [BibTex]

DOI [BibTex]


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What is epistemic value in free energy models of learning and acting? A bounded rationality perspective

Ortega, PA, Braun, DA

Cognitive Neuroscience, 6(4):215-216, December 2015 (article)

Abstract
Free energy models of learning and acting do not only care about utility or extrinsic value, but also about intrinsic value, that is, the information value stemming from probability distributions that represent beliefs or strategies. While these intrinsic values can be interpreted as epistemic values or exploration bonuses under certain conditions, the framework of bounded rationality offers a complementary interpretation in terms of information-processing costs that we discuss here.

ei

DOI [BibTex]

DOI [BibTex]

2006


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Structure validation of the Josephin domain of ataxin-3: Conclusive evidence for an open conformation

Nicastro, G., Habeck, M., Masino, L., Svergun, DI., Pastore, A.

Journal of Biomolecular NMR, 36(4):267-277, December 2006 (article)

Abstract
The availability of new and fast tools in structure determination has led to a more than exponential growth of the number of structures solved per year. It is therefore increasingly essential to assess the accuracy of the new structures by reliable approaches able to assist validation. Here, we discuss a specific example in which the use of different complementary techniques, which include Bayesian methods and small angle scattering, resulted essential for validating the two currently available structures of the Josephin domain of ataxin-3, a protein involved in the ubiquitin/proteasome pathway and responsible for neurodegenerative spinocerebellar ataxia of type 3. Taken together, our results demonstrate that only one of the two structures is compatible with the experimental information. Based on the high precision of our refined structure, we show that Josephin contains an open cleft which could be directly implicated in the interaction with polyubiquitin chains and other partners.

ei

Web DOI [BibTex]

2006


Web DOI [BibTex]


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A Unifying View of Wiener and Volterra Theory and Polynomial Kernel Regression

Franz, M., Schölkopf, B.

Neural Computation, 18(12):3097-3118, December 2006 (article)

Abstract
Volterra and Wiener series are perhaps the best understood nonlinear system representations in signal processing. Although both approaches have enjoyed a certain popularity in the past, their application has been limited to rather low-dimensional and weakly nonlinear systems due to the exponential growth of the number of terms that have to be estimated. We show that Volterra and Wiener series can be represented implicitly as elements of a reproducing kernel Hilbert space by utilizing polynomial kernels. The estimation complexity of the implicit representation is linear in the input dimensionality and independent of the degree of nonlinearity. Experiments show performance advantages in terms of convergence, interpretability, and system sizes that can be handled.

ei

PDF Web DOI [BibTex]

PDF Web DOI [BibTex]


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Statistical Analysis of Slow Crack Growth Experiments

Pfingsten, T., Glien, K.

Journal of the European Ceramic Society, 26(15):3061-3065, November 2006 (article)

Abstract
A common approach for the determination of Slow Crack Growth (SCG) parameters are the static and dynamic loading method. Since materials with small Weibull module show a large variability in strength, a correct statistical analysis of the data is indispensable. In this work we propose the use of the Maximum Likelihood method and a Baysian analysis, which, in contrast to the standard procedures, take into account that failure strengths are Weibull distributed. The analysis provides estimates for the SCG parameters, the Weibull module, and the corresponding confidence intervals and overcomes the necessity of manual differentiation between inert and fatigue strength data. We compare the methods to a Least Squares approach, which can be considered the standard procedure. The results for dynamic loading data from the glass sealing of MEMS devices show that the assumptions inherent to the standard approach lead to significantly different estimates.

ei

PDF PDF DOI [BibTex]

PDF PDF DOI [BibTex]


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Mining frequent stem patterns from unaligned RNA sequences

Hamada, M., Tsuda, K., Kudo, T., Kin, T., Asai, K.

Bioinformatics, 22(20):2480-2487, October 2006 (article)

Abstract
Motivation: In detection of non-coding RNAs, it is often necessary to identify the secondary structure motifs from a set of putative RNA sequences. Most of the existing algorithms aim to provide the best motif or few good motifs, but biologists often need to inspect all the possible motifs thoroughly. Results: Our method RNAmine employs a graph theoretic representation of RNA sequences, and detects all the possible motifs exhaustively using a graph mining algorithm. The motif detection problem boils down to finding frequently appearing patterns in a set of directed and labeled graphs. In the tasks of common secondary structure prediction and local motif detection from long sequences, our method performed favorably both in accuracy and in efficiency with the state-of-the-art methods such as CMFinder.

ei

PDF Web DOI [BibTex]

PDF Web DOI [BibTex]


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Large-Scale Gene Expression Profiling Reveals Major Pathogenetic Pathways of Cartilage Degeneration in Osteoarthritis

Aigner, T., Fundel, K., Saas, J., Gebhard, P., Haag, J., Weiss, T., Zien, A., Obermayr, F., Zimmer, R., Bartnik, E.

Arthritis and Rheumatism, 54(11):3533-3544, October 2006 (article)

Abstract
Objective. Despite many research efforts in recent decades, the major pathogenetic mechanisms of osteo- arthritis (OA), including gene alterations occurring during OA cartilage degeneration, are poorly under- stood, and there is no disease-modifying treatment approach. The present study was therefore initiated in order to identify differentially expressed disease-related genes and potential therapeutic targets. Methods. This investigation consisted of a large gene expression profiling study performed based on 78 normal and disease samples, using a custom-made complementar y DNA array covering >4,000 genes. Results. Many differentially expressed genes were identified, including the expected up-regulation of ana- bolic and catabolic matrix genes. In particular, the down-regulation of important oxidative defense genes, i.e., the genes for superoxide dismutases 2 and 3 and glutathione peroxidase 3, was prominent. This indicates that continuous oxidative stress to the cells and the matrix is one major underlying pathogenetic mecha- nism in OA. Also, genes that are involved in the phenot ypic stabilit y of cells, a feature that is greatly reduced in OA cartilage, appeared to be suppressed. Conclusion. Our findings provide a reference data set on gene alterations in OA cartilage and, importantly, indicate major mechanisms underlying central cell bio- logic alterations that occur during the OA disease process. These results identify molecular targets that can be further investigated in the search for therapeutic interventions.

ei

Web DOI [BibTex]

Web DOI [BibTex]


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Implicit Surface Modelling with a Globally Regularised Basis of Compact Support

Walder, C., Schölkopf, B., Chapelle, O.

Computer Graphics Forum, 25(3):635-644, September 2006 (article)

Abstract
We consider the problem of constructing a globally smooth analytic function that represents a surface implicitly by way of its zero set, given sample points with surface normal vectors. The contributions of the paper include a novel means of regularising multi-scale compactly supported basis functions that leads to the desirable interpolation properties previously only associated with fully supported bases. We also provide a regularisation framework for simpler and more direct treatment of surface normals, along with a corresponding generalisation of the representer theorem lying at the core of kernel-based machine learning methods. We demonstrate the techniques on 3D problems of up to 14 million data points, as well as 4D time series data and four-dimensional interpolation between three-dimensional shapes.

ei

PDF GZIP DOI [BibTex]


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An Online Support Vector Machine for Abnormal Events Detection

Davy, M., Desobry, F., Gretton, A., Doncarli, C.

Signal Processing, 86(8):2009-2025, August 2006 (article)

Abstract
The ability to detect online abnormal events in signals is essential in many real-world Signal Processing applications. Previous algorithms require an explicit signal statistical model, and interpret abnormal events as statistical model abrupt changes. Corresponding implementation relies on maximum likelihood or on Bayes estimation theory with generally excellent performance. However, there are numerous cases where a robust and tractable model cannot be obtained, and model-free approaches need to be considered. In this paper, we investigate a machine learning, descriptor-based approach that does not require an explicit descriptors statistical model, based on Support Vector novelty detection. A sequential optimization algorithm is introduced. Theoretical considerations as well as simulations on real signals demonstrate its practical efficiency.

ei

PDF PostScript PDF DOI [BibTex]

PDF PostScript PDF DOI [BibTex]


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Integrating Structured Biological data by Kernel Maximum Mean Discrepancy

Borgwardt, K., Gretton, A., Rasch, M., Kriegel, H., Schölkopf, B., Smola, A.

Bioinformatics, 22(4: ISMB 2006 Conference Proceedings):e49-e57, August 2006 (article)

Abstract
Motivation: Many problems in data integration in bioinformatics can be posed as one common question: Are two sets of observations generated by the same distribution? We propose a kernel-based statistical test for this problem, based on the fact that two distributions are different if and only if there exists at least one function having different expectation on the two distributions. Consequently we use the maximum discrepancy between function means as the basis of a test statistic. The Maximum Mean Discrepancy (MMD) can take advantage of the kernel trick, which allows us to apply it not only to vectors, but strings, sequences, graphs, and other common structured data types arising in molecular biology. Results: We study the practical feasibility of an MMD-based test on three central data integration tasks: Testing cross-platform comparability of microarray data, cancer diagnosis, and data-content based schema matching for two different protein function classification schemas. In all of these experiments, including high-dimensional ones, MMD is very accurate in finding samples that were generated from the same distribution, and outperforms its best competitors. Conclusions: We have defined a novel statistical test of whether two samples are from the same distribution, compatible with both multivariate and structured data, that is fast, easy to implement, and works well, as confirmed by our experiments.

ei

Web DOI [BibTex]

Web DOI [BibTex]