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2019


Soft Continuous Surface for Micromanipulation driven by Light-controlled Hydrogels
Soft Continuous Surface for Micromanipulation driven by Light-controlled Hydrogels

Choi, E., Jeong, H., Qiu, T., Fischer, P., Palagi, S.

4th IEEE International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS), July 2019 (conference)

Abstract
Remotely controlled, automated actuation and manipulation at the microscale is essential for a number of micro-manufacturing, biology, and lab-on-a-chip applications. To transport and manipulate micro-objects, arrays of remotely controlled micro-actuators are required, which, in turn, typically require complex and expensive solid-state chips. Here, we show that a continuous surface can function as a highly parallel, many-degree of freedom, wirelessly-controlled microactuator with seamless deformation. The soft continuous surface is based on a hydrogel that undergoes a volume change in response to applied light. The fabrication of the hydrogels and the characterization of their optical and thermomechanical behaviors are reported. The temperature-dependent localized deformation of the hydrogel is also investigated by numerical simulations. Static and dynamic deformations are obtained in the soft material by projecting light fields at high spatial resolution onto the surface. By controlling such deformations in open loop and especially closed loop, automated photoactuation is achieved. The surface deformations are then exploited to examine how inert microbeads can be manipulated autonomously on the surface. We believe that the proposed approach suggests ways to implement universal 2D micromanipulation schemes that can be useful for automation in microfabrication and lab-on-a-chip applications.

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[BibTex]

2019


[BibTex]


Soft Phantom for the Training of Renal Calculi Diagnostics and  Lithotripsy
Soft Phantom for the Training of Renal Calculi Diagnostics and Lithotripsy

Li., D., Suarez-Ibarrola, R., Choi, E., Jeong, M., Gratzke, C., Miernik, A., Fischer, P., Qiu, T.

41st Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), July 2019 (conference)

Abstract
Organ models are important for medical training and surgical planning. With the fast development of additive fabrication technologies, including 3D printing, the fabrication of 3D organ phantoms with precise anatomical features becomes possible. Here, we develop the first high-resolution kidney phantom based on soft material assembly, by combining 3D printing and polymer molding techniques. The phantom exhibits both the detailed anatomy of a human kidney and the elasticity of soft tissues. The phantom assembly can be separated into two parts on the coronal plane, thus large renal calculi are readily placed at any desired location of the calyx. With our sealing method, the assembled phantom withstands a hydraulic pressure that is four times the normal intrarenal pressure, thus it allows the simulation of medical procedures under realistic pressure conditions. The medical diagnostics of the renal calculi is performed by multiple imaging modalities, including X-ray, ultrasound imaging and endoscopy. The endoscopic lithotripsy is also successfully performed on the phantom. The use of a multifunctional soft phantom assembly thus shows great promise for the simulation of minimally invasive medical procedures under realistic conditions.

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[BibTex]

[BibTex]


A Magnetic Actuation System for the  Active Microrheology in Soft Biomaterials
A Magnetic Actuation System for the Active Microrheology in Soft Biomaterials

Jeong, M., Choi, E., Li., D., Palagi, S., Fischer, P., Qiu, T.

4th IEEE International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS), July 2019 (conference)

Abstract
Microrheology is a key technique to characterize soft materials at small scales. The microprobe is wirelessly actuated and therefore typically only low forces or torques can be applied, which limits the range of the applied strain. Here, we report a new magnetic actuation system for microrheology consisting of an array of rotating permanent magnets, which achieves a rotating magnetic field with a spatially homogeneous high field strength of ~100 mT in a working volume of ~20×20×20 mm3. Compared to a traditional electromagnetic coil system, the permanent magnet assembly is portable and does not require cooling, and it exerts a large magnetic torque on the microprobe that is an order of magnitude higher than previous setups. Experimental results demonstrate that the measurement range of the soft gels’ elasticity covers at least five orders of magnitude. With the large actuation torque, it is also possible to study the fracture mechanics of soft biomaterials at small scales.

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[BibTex]

[BibTex]


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Prototyping Micro- and Nano-Optics with Focused Ion Beam Lithography

Keskinbora, K.

SL48, pages: 46, SPIE.Spotlight, SPIE Press, Bellingham, WA, 2019 (book)

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DOI [BibTex]

DOI [BibTex]

2017


Locomotion of light-driven soft microrobots through a hydrogel via local melting
Locomotion of light-driven soft microrobots through a hydrogel via local melting

Palagi, S., Mark, A. G., Melde, K., Qiu, T., Zeng, H., Parmeggiani, C., Martella, D., Wiersma, D. S., Fischer, P.

In 2017 International Conference on Manipulation, Automation and Robotics at Small Scales (MARSS), pages: 1-5, July 2017 (inproceedings)

Abstract
Soft mobile microrobots whose deformation can be directly controlled by an external field can adapt to move in different environments. This is the case for the light-driven microrobots based on liquid-crystal elastomers (LCEs). Here we show that the soft microrobots can move through an agarose hydrogel by means of light-controlled travelling-wave motions. This is achieved by exploiting the inherent rise of the LCE temperature above the melting temperature of the agarose gel, which facilitates penetration of the microrobot through the hydrogel. The locomotion performance is investigated as a function of the travelling-wave parameters, showing that effective propulsion can be obtained by adapting the generated motion to the specific environmental conditions.

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DOI [BibTex]

2017


DOI [BibTex]


Wireless micro-robots for endoscopic applications in urology
Wireless micro-robots for endoscopic applications in urology

Adams, F., Qiu, T., Mark, A. G., Melde, K., Palagi, S., Miernik, A., Fischer, P.

In Eur Urol Suppl, 16(3):e1914, March 2017 (inproceedings)

Abstract
Endoscopy is an essential and common method for both diagnostics and therapy in Urology. Current flexible endoscope is normally cable-driven, thus it is hard to be miniaturized and its reachability is restricted as only one bending section near the tip with one degree of freedom (DoF) is allowed. Recent progresses in micro-robotics offer a unique opportunity for medical inspections in minimally invasive surgery. Micro-robots are active devices that has a feature size smaller than one millimeter and can normally be actuated and controlled wirelessly. Magnetically actuated micro-robots have been demonstrated to propel through biological fluids.Here, we report a novel micro robotic arm, which is actuated wirelessly by ultrasound. It works as a miniaturized endoscope with a side length of ~1 mm, which fits through the 3 Fr. tool channel of a cystoscope, and successfully performs an active cystoscopy in a rabbit bladder.

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link (url) DOI [BibTex]

2014


3D nanofabrication on complex seed shapes using glancing angle deposition
3D nanofabrication on complex seed shapes using glancing angle deposition

Hyeon-Ho, J., Mark, A. G., Gibbs, J. G., Reindl, T., Waizmann, U., Weis, J., Fischer, P.

In 2014 IEEE 27th International Conference on Micro Electro Mechanical Systems (MEMS), pages: 437-440, January 2014 (inproceedings)

Abstract
Three-dimensional (3D) fabrication techniques promise new device architectures and enable the integration of more components, but fabricating 3D nanostructures for device applications remains challenging. Recently, we have performed glancing angle deposition (GLAD) upon a nanoscale hexagonal seed array to create a variety of 3D nanoscale objects including multicomponent rods, helices, and zigzags [1]. Here, in an effort to generalize our technique, we present a step-by-step approach to grow 3D nanostructures on more complex nanoseed shapes and configurations than before. This approach allows us to create 3D nanostructures on nanoseeds regardless of seed sizes and shapes.

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DOI [BibTex]

2014


DOI [BibTex]


Active Microrheology of the Vitreous of the Eye applied to Nanorobot Propulsion
Active Microrheology of the Vitreous of the Eye applied to Nanorobot Propulsion

Qiu, T., Schamel, D., Mark, A. G., Fischer, P.

In 2014 IEEE INTERNATIONAL CONFERENCE ON ROBOTICS AND AUTOMATION (ICRA), pages: 3801-3806, IEEE International Conference on Robotics and Automation ICRA, 2014, Best Automation Paper Award – Finalist. (inproceedings)

Abstract
Biomedical applications of micro or nanorobots require active movement through complex biological fluids. These are generally non-Newtonian (viscoelastic) fluids that are characterized by complicated networks of macromolecules that have size-dependent rheological properties. It has been suggested that an untethered microrobot could assist in retinal surgical procedures. To do this it must navigate the vitreous humor, a hydrated double network of collagen fibrils and high molecular-weight, polyanionic hyaluronan macromolecules. Here, we examine the characteristic size that potential robots must have to traverse vitreous relatively unhindered. We have constructed magnetic tweezers that provide a large gradient of up to 320 T/m to pull sub-micron paramagnetic beads through biological fluids. A novel two-step electrical discharge machining (EDM) approach is used to construct the tips of the magnetic tweezers with a resolution of 30 mu m and high aspect ratio of similar to 17:1 that restricts the magnetic field gradient to the plane of observation. We report measurements on porcine vitreous. In agreement with structural data and passive Brownian diffusion studies we find that the unhindered active propulsion through the eye calls for nanorobots with cross-sections of less than 500 nm.

Best Automation Paper Award – Finalist.

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[BibTex]

[BibTex]


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Increasing the sensor performance using Au modified high temperature superconducting YBa2Cu3O7-delta thin films

Katzer, C., Stahl, C., Michalowski, P., Treiber, S., Westernhausen, M., Schmidl, F., Seidel, P., Schütz, G., Albrecht, J.

In 507, IOP Pub., Genova, Italy, 2014 (inproceedings)

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DOI [BibTex]

DOI [BibTex]

2011


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Amorphous grain boundary layers in the ferromagnetic nanograined ZnO films

Straumal, B. B., Mazilkin, A. A., Protasova, S. G., Myatiev, A. A., Straumal, P. B., Goering, E., Baretzky, B.

In 520, pages: 1192-1194, Hersonissos, Greece, 2011 (inproceedings)

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DOI [BibTex]

2011


DOI [BibTex]


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Inversed solid-phase grain boundary wetting in the Al-Zn system

Protasova, S. G., Kogtenkova, O. A., Straumal, B. B., Zieba, P., Baretzky, B.

In 46, pages: 4349-4353, Mie, Japan, 2011 (inproceedings)

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DOI [BibTex]

DOI [BibTex]


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First measurement of the heat effect of the grain boundary wetting phase transition

Straumal, B. B., Kogtenkova, O. A., Protasova, S. G., Zieba, P., Czeppe, T., Baretzky, B., Valiev, R. Z.

In 46, pages: 4243, Mie, Japan, 2011 (inproceedings)

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DOI [BibTex]

DOI [BibTex]


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Transmission electron microscopy investigation of boundaries between amorphous "grains" in Ni50Nb20Y30 alloy

Mazilkin, A. A., Abrosimova, G. E., Protasova, S. G., Straumal, B. B., Schütz, G., Dobatkin, S. V., Bakai, A. S.

In 46, pages: 4336-4342, Mie, Japan, 2011 (inproceedings)

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DOI [BibTex]

DOI [BibTex]

2002


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Pressure Isotherms of Hydrogen Adsorption in Carbon Nanostructures

Chen, X., Dettlaff-Weglikowska, U., Haluska, M., Hulman, M., Roth, S., Hirscher, M., Becher, M.

In Making Functional Materials with Nanotubes, pages: Z9.11.1-Z9.11.6, Materials Research Society Symposium Proceedings, MRS, Boston [Mass.], 2002 (inproceedings)

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2002


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Hydrogen Storage in Carbon SWNTs: Atomic or Molecular?

Haluska, M., Hirscher, M., Becher, M., Dettlaff-Weglikowska, U., Chen, X., Roth, S.

In Structural and Electronic Properties of Molecular Nanostructures, pages: 601-605, AIP Conference Proceedings, AIP, Kirchberg, Tirol [Austria], 2002 (inproceedings)

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[BibTex]


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Hydrogen Storage in Nanostructured Carbon Materials at Room Temperature

Chen, X., Dettlaff-Weglikowska, U., Haluska, M., Hirscher, M., Becher, M., Roth, S.

In Structural and Electronic Properties of Molecular Nanostructures, pages: 597-600, AIP Conference Proceedings, AIP, Kirchberg, Tirol [Austria], 2002 (inproceedings)

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[BibTex]


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Micromagnetism and the microstructure of the cell walls in Sm2Co17 based permanent magnets

Goll, D., Hadjipanayis, G. C., Kronmüller, H.

In Proceedings of the 17th International Workshop on Rare-Earth Magnets and their Applications, pages: 696-703, Rinton Press, Newark, Delaware, USA, 2002 (inproceedings)

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[BibTex]


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Ab-initio study of the influence of epitaxial strain on magnetoelastic properties

Komelj, M., Fähnle, M.

In Atomistic Aspects of Epitaxial Growth, pages: 439-447, NATO Science series: Series 2, Mathematics, Physics, and Chemistry, Kluwer Academic Publishers, Dassia, Corfu [Greece], 2002 (inproceedings)

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[BibTex]

[BibTex]