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2019


Soft-magnetic coatings as possible sensors for magnetic imaging of superconductors
Soft-magnetic coatings as possible sensors for magnetic imaging of superconductors

Ionescu, A., Simmendinger, J., Bihler, M., Miksch, C., Fischer, P., Soltan, S., Schütz, G., Albrecht, J.

Supercond. Sci. and Tech., 33, pages: 015002, IOP, December 2019 (article)

Abstract
Magnetic imaging of superconductors typically requires a soft-magnetic material placed on top of the superconductor to probe local magnetic fields. For reasonable results the influence of the magnet onto the superconductor has to be small. Thin YBCO films with soft-magnetic coatings are investigated using SQUID magnetometry. Detailed measurements of the magnetic moment as a function of temperature, magnetic field and time have been performed for different heterostructures. It is found that the modification of the superconducting transport in these heterostructures strongly depends on the magnetic and structural properties of the soft-magnetic material. This effect is especially pronounced for an inhomogeneous coating consisting of ferromagnetic nanoparticles.

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link (url) DOI [BibTex]

2019


link (url) DOI [BibTex]


HPLC of monolayer-protected Gold clusters with baseline separation
HPLC of monolayer-protected Gold clusters with baseline separation

Knoppe, S., Vogt, P.

Analytical Chemistry, 91, pages: 1603, December 2019 (article)

Abstract
The properties of ultrasmall metal nanoparticles (ca. 10–200 metal atoms), or monolayer-protected metal clusters (MPCs), drastically depend on their atomic structure. For systematic characterization and application, assessment of their purity is of high importance. Currently, the gold standard for purity control of MPCs is mass spectrometry (MS). Mass spectrometry, however, cannot always detect small impurities; MS of certain clusters, for example, ESI-TOF of Au40(SR)24, is not successful at all. We here present a simple reversed-phase HPLC method for purity control of a series of small alkanethiolate-protected gold clusters. The method allows the detection of small impurities with high sensitivity. Linear correlation between alkyl chain length of Au25(SC_n H_(2n+1))18 clusters (n = 6, 8, 10, 12) and their retention time was noticed.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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A semi-analytical model for dynamic analysis of non-uniform plates

Gozum, M. M., Serhat, G., Basdogan, I.

Applied Mathematical Modelling, 76, pages: 883–899, December 2019 (article)

Abstract
Dynamic properties of the plate structures can be enhanced by introducing discontinuities of different kinds such as using surface-bonded discrete patches or spatially varying the stiffness and mass properties of the plate. Fast and reliable design of such complex structures requires efficient and accurate modeling tools. In this study, a novel semi-analytical model is developed for the dynamic analysis of plates having discrete and/or continuous non-uniformities. Two-dimensional Heaviside unit step functions are utilized to represent the discontinuities. Different from existing numerical methods based on Heaviside functions, a numerical technique is proposed for modeling the discontinuities that are not necessarily aligned with the plate axes. The governing equations are derived using Hamilton's principle and Rayleigh–Ritz method is used for determining the modal variables. The surface-bonded patches are used to demonstrate discrete non-uniformities where variable-stiffness laminates are selected to represent continuous non-uniform structures. Natural frequencies and mode shapes obtained using the proposed method are validated with finite element analyses and the existing results from the literature. The results show that the developed model performs accurately and efficiently.

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DOI [BibTex]

DOI [BibTex]


A Robotic Framework to Facilitate Sensory Experiences for Children with Autism Spectrum Disorder: A Preliminary Study
A Robotic Framework to Facilitate Sensory Experiences for Children with Autism Spectrum Disorder: A Preliminary Study

Javed, H., Burns, R., Jeong, M., Howard, A. M., Park, C. H.

ACM Transactions on Human-Robot Interaction (THRI), 9(1), December 2019 (article)

Abstract
The diagnosis of Autism Spectrum Disorder (ASD) in children is commonly accompanied by a diagnosis of sensory processing disorders. Abnormalities are usually reported in multiple sensory processing domains, showing a higher prevalence of unusual responses, particularly to tactile, auditory, and visual stimuli. This article discusses a novel robot-based framework designed to target sensory difficulties faced by children with ASD in a controlled setting. The setup consists of a number of sensory stations, together with two different robotic agents that navigate the stations and interact with the stimuli. These stimuli are designed to resemble real-world scenarios that form a common part of one’s everyday experiences. Given the strong interest of children with ASD in technology in general and robots in particular, we attempt to utilize our robotic platform to demonstrate socially acceptable responses to the stimuli in an interactive, pedagogical setting that encourages the child’s social, motor, and vocal skills, while providing a diverse sensory experience. A preliminary user study was conducted to evaluate the efficacy of the proposed framework, with a total of 18 participants (5 with ASD and 13 typically developing) between the ages of 4 and 12 years. We derive a measure of social engagement, based on which we evaluate the effectiveness of the robots and sensory stations to identify key design features that can improve social engagement in children.

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DOI [BibTex]

DOI [BibTex]


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Hierarchical Task-Parameterized Learning from Demonstration for Collaborative Object Movement

Hu, S., Kuchenbecker, K. J.

Applied Bionics and Biomechanics, (9765383), December 2019 (article)

Abstract
Learning from demonstration (LfD) enables a robot to emulate natural human movement instead of merely executing preprogrammed behaviors. This article presents a hierarchical LfD structure of task-parameterized models for object movement tasks, which are ubiquitous in everyday life and could benefit from robotic support. Our approach uses the task-parameterized Gaussian mixture model (TP-GMM) algorithm to encode sets of demonstrations in separate models that each correspond to a different task situation. The robot then maximizes its expected performance in a new situation by either selecting a good existing model or requesting new demonstrations. Compared to a standard implementation that encodes all demonstrations together for all test situations, the proposed approach offers four advantages. First, a simply defined distance function can be used to estimate test performance by calculating the similarity between a test situation and the existing models. Second, the proposed approach can improve generalization, e.g., better satisfying the demonstrated task constraints and speeding up task execution. Third, because the hierarchical structure encodes each demonstrated situation individually, a wider range of task situations can be modeled in the same framework without deteriorating performance. Last, adding or removing demonstrations incurs low computational load, and thus, the robot’s skill library can be built incrementally. We first instantiate the proposed approach in a simulated task to validate these advantages. We then show that the advantages transfer to real hardware for a task where naive participants collaborated with a Willow Garage PR2 robot to move a handheld object. For most tested scenarios, our hierarchical method achieved significantly better task performance and subjective ratings than both a passive model with only gravity compensation and a single TP-GMM encoding all demonstrations.

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DOI [BibTex]


Life Improvement Science: A Manifesto
Life Improvement Science: A Manifesto

Lieder, F.

December 2019 (article) In revision

Abstract
Rapid technological advances present unprecedented opportunities for helping people thrive. This manifesto presents a road map for establishing a solid scientific foundation upon which those opportunities can be realized. It highlights fundamental open questions about the cognitive underpinnings of effective living and how they can be improved, supported, and augmented. These questions are at the core of my proposal for a new transdisciplinary research area called life improvement science. Recent advances have made these questions amenable to scientific rigor, and emerging approaches are paving the way towards practical strategies, clever interventions, and (intelligent) apps for empowering people to reach unprecedented levels of personal effectiveness and wellbeing.

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Life improvement science: a manifesto DOI [BibTex]


Acoustic hologram enhanced phased arrays for ultrasonic particle manipulation
Acoustic hologram enhanced phased arrays for ultrasonic particle manipulation

Cox, L., Melde, K., Croxford, A., Fischer, P., Drinkwater, B.

Phys. Rev. Applied, 12, pages: 064055, November 2019 (article)

Abstract
The ability to shape ultrasound fields is important for particle manipulation, medical therapeutics and imaging applications. If the amplitude and/or phase is spatially varied across the wavefront then it is possible to project ‘acoustic images’. When attempting to form an arbitrary desired static sound field, acoustic holograms are superior to phased arrays due to their significantly higher phase fidelity. However, they lack the dynamic flexibility of phased arrays. Here, we demonstrate how to combine the high-fidelity advantages of acoustic holograms with the dynamic control of phased arrays in the ultrasonic frequency range. Holograms are used with a 64-element phased array, driven with continuous excitation. Moving the position of the projected hologram via phase delays which steer the output beam is demonstrated experimentally. This allows the creation of a much more tightly focused point than with the phased array alone, whilst still being reconfigurable. It also allows the complex movement at a water-air interface of a “phase surfer” along a phase track or the manipulation of a more arbitrarily shaped particle via amplitude traps. Furthermore, a particle manipulation device with two emitters and a single split hologram is demonstrated that allows the positioning of a “phase surfer” along a 1D axis. This paper opens the door for new applications with complex manipulation of ultrasound whilst minimising the complexity and cost of the apparatus.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


A Helical Microrobot with an Optimized Propeller-Shape for Propulsion in Viscoelastic Biological Media
A Helical Microrobot with an Optimized Propeller-Shape for Propulsion in Viscoelastic Biological Media

Li., D., Jeong, M., Oren, E., Yu, T., Qiu, T.

Robotics, 8, pages: 87, MDPI, October 2019 (article)

Abstract
One major challenge for microrobots is to penetrate and effectively move through viscoelastic biological tissues. Most existing microrobots can only propel in viscous liquids. Recent advances demonstrate that sub-micron robots can actively penetrate nanoporous biological tissue, such as the vitreous of the eye. However, it is still difficult to propel a micron-sized device through dense biological tissue. Here, we report that a special twisted helical shape together with a high aspect ratio in cross-section permit a microrobot with a diameter of hundreds-of-micrometers to move through mouse liver tissue. The helical microrobot is driven by a rotating magnetic field and localized by ultrasound imaging inside the tissue. The twisted ribbon is made of molybdenum and a sharp tip is chemically etched to generate a higher pressure at the edge of the propeller to break the biopolymeric network of the dense tissue.

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link (url) DOI [BibTex]


Acoustic Holographic Cell Patterning in a Biocompatible Hydrogel
Acoustic Holographic Cell Patterning in a Biocompatible Hydrogel

Ma, Z., Holle, A., Melde, K., Qiu, T., Poeppel, K., Kadiri, V., Fischer, P.

Adv. Mat., 32(1904181), October 2019 (article)

Abstract
Acoustophoresis is promising as a rapid, biocompatible, non-contact cell manipulation method, where cells are arranged along the nodes or antinodes of the acoustic field. Typically, the acoustic field is formed in a resonator, which results in highly symmetric regular patterns. However, arbitrary, non-symmetrically shaped cell assemblies are necessary to obtain the irregular cellular arrangements found in biological tissues. We show that arbitrarily shaped cell patterns can be obtained from the complex acoustic field distribution defined by an acoustic hologram. Attenuation of the sound field induces localized acoustic streaming and the resultant convection flow gently delivers the suspended cells to the image plane where they form the designed pattern. We show that the process can be implemented in a biocompatible collagen solution, which can then undergo gelation to immobilize the cell pattern inside the viscoelastic matrix. The patterned cells exhibit F-actin-based protrusions, which indicates that the cells grow and thrive within the matrix. Cell viability assays and brightfield imaging after one week confirm cell survival and that the patterns persist. Acoustophoretic cell manipulation by holographic fields thus holds promise for non-contact, long-range, long-term cellular pattern formation, with a wide variety of potential applications in tissue engineering and mechanobiology.

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link (url) DOI [BibTex]


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Doing More with Less: Meta-Reasoning and Meta-Learning in Humans and Machines

Griffiths, T. L., Callaway, F., Chang, M. B., Grant, E., Krueger, P. M., Lieder, F.

Current Opinion in Behavioral Sciences, 29, pages: 24-30, October 2019 (article)

Abstract
Artificial intelligence systems use an increasing amount of computation and data to solve very specific problems. By contrast, human minds solve a wide range of problems using a fixed amount of computation and limited experience. We identify two abilities that we see as crucial to this kind of general intelligence: meta-reasoning (deciding how to allocate computational resources) and meta-learning (modeling the learning environment to make better use of limited data). We summarize the relevant AI literature and relate the resulting ideas to recent work in psychology.

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DOI [BibTex]

DOI [BibTex]


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Multi-objective optimization of composite plates using lamination parameters

Serhat, G., Basdogan, I.

Materials & Design, 180(107904), October 2019 (article)

Abstract
Laminated composite plates are extensively used in various industries due to their high stiffness-to-weight ratio and directional properties that allow optimization of the stiffness characteristics for specific applications. In multi-objective optimization problems, optimal designs for individual performance metrics may be conflicting, necessitating knowledge on the design requirements for different metrics and potential trade-offs. In this paper, a multi-objective design methodology for laminated composite plates with dynamic and load-carrying requirements is presented. Lamination parameters are used to characterize laminate stiffness matrices in a compact form resulting in a convex design space. Single and multi-objective optimization studies are carried out to determine the optimal stiffness properties. For improving the dynamic performance, maximization of the fundamental frequency metric is aimed. For enhancing the load-carrying capability, buckling load and equivalent stiffness metrics are maximized. Conforming and conflicting behavior of multiple objective functions for different plate geometries, boundary conditions and load cases are presented by determining Pareto-optimal solutions. The results provide a valuable insight for multi-objective optimization of laminated composite plates and show that presented methodology can be used in the design of such structures for improving the dynamic and load-carrying performance.

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DOI [BibTex]

DOI [BibTex]


Arrays of plasmonic nanoparticle dimers with defined nanogap spacers
Arrays of plasmonic nanoparticle dimers with defined nanogap spacers

Jeong, H., Adams, M. C., Guenther, J., Alarcon-Correa, M., Kim, I., Choi, E., Miksch, C., Mark, A. F. M., Mark, A. G., Fischer, P.

ACS Nano, 13, pages: 11453-11459, September 2019 (article)

Abstract
Plasmonic molecules are building blocks of metallic nanostructures that give rise to intriguing optical phenomena with similarities to those seen in molecular systems. The ability to design plasmonic hybrid structures and molecules with nanometric resolution would enable applications in optical metamaterials and sensing that presently cannot be demonstrated, because of a lack of suitable fabrication methods allowing the structural control of the plasmonic atoms on a large scale. Here we demonstrate a wafer-scale “lithography-free” parallel fabrication scheme to realize nanogap plasmonic meta-molecules with precise control over their size, shape, material, and orientation. We demonstrate how we can tune the corresponding coupled resonances through the entire visible spectrum. Our fabrication method, based on glancing angle physical vapor deposition with gradient shadowing, permits critical parameters to be varied across the wafer and thus is ideally suited to screen potential structures. We obtain billions of aligned dimer structures with controlled variation of the spectral properties across the wafer. We spectroscopically map the plasmonic resonances of gold dimer structures and show that they not only are in good agreement with numerically modeled spectra, but also remain functional, at least for a year, in ambient conditions.

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link (url) DOI [BibTex]


Genetically modified M13 bacteriophage nanonets for enzyme catalysis and recovery
Genetically modified M13 bacteriophage nanonets for enzyme catalysis and recovery

Kadiri, V. M., Alarcon-Correa, M., Guenther, J. P., Ruppert, J., Bill, J., Rothenstein, D., Fischer, P.

Catalysts, 9, pages: 723, August 2019 (article)

Abstract
Enzyme-based biocatalysis exhibits multiple advantages over inorganic catalysts, including the biocompatibility and the unchallenged specificity of enzymes towards their substrate. The recovery and repeated use of enzymes is essential for any realistic application in biotechnology, but is not easily achieved with current strategies. For this purpose, enzymes are often immobilized on inorganic scaffolds, which could entail a reduction of the enzymes’ activity. Here, we show that immobilization to a nano-scaled biological scaffold, a nanonetwork of end-to-end cross-linked M13 bacteriophages, ensures high enzymatic activity and at the same time allows for the simple recovery of the enzymes. The bacteriophages have been genetically engineered to express AviTags at their ends, which permit biotinylation and their specific end-to-end self-assembly while allowing space on the major coat protein for enzyme coupling. We demonstrate that the phages form nanonetwork structures and that these so-called nanonets remain highly active even after re-using the nanonets multiple times in a flow-through reactor.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


Light-controlled micromotors and soft microrobots
Light-controlled micromotors and soft microrobots

Palagi, S., Singh, D. P., Fischer, P.

Adv. Opt. Mat., 7, pages: 1900370, August 2019 (article)

Abstract
Mobile microscale devices and microrobots can be powered by catalytic reactions (chemical micromotors) or by external fields. This report is focused on the role of light as a versatile means for wirelessly powering and controlling such microdevices. Recent advances in the development of autonomous micromotors are discussed, where light permits their actuation with unprecedented control and thereby enables advances in the field of active matter. In addition, structuring the light field is a new means to drive soft microrobots that are based on (photo‐) responsive polymers. The behavior of the two main classes of thermo‐ and photoresponsive polymers adopted in microrobotics (poly(N‐isopropylacrylamide) and liquid‐crystal elastomers) is analyzed, and recent applications are reported. The advantages and limitations of controlling micromotors and microrobots by light are reviewed, and some of the remaining challenges in the development of novel photo‐active materials for micromotors and microrobots are discussed.

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link (url) DOI [BibTex]


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Low-Hysteresis and Low-Interference Soft Tactile Sensor Using a Conductive Coated Porous Elastomer and a Structure for Interference Reduction

Park, K., Kim, S., Lee, H., Park, I., Kim, J.

Sensors and Actuators A: Physical, 295, pages: 541-550, August 2019 (article)

Abstract
The need for soft whole-body tactile sensors is emerging. Piezoresistive materials are advantageous in terms of making large tactile sensors, but the hysteresis of piezoresistive materials is a major drawback. The hysteresis of a piezoresistive material should be attenuated to make a practical piezoresistive soft tactile sensor. In this paper, we introduce a low-hysteresis and low-interference soft tactile sensor using a conductive coated porous elastomer and a structure to reduce interference (grooves). The developed sensor exhibits low hysteresis because the transduction mechanism of the sensor is dominated by the contact between the conductive coated surface. In a cyclic loading experiment with different loading frequencies, the mechanical and piezoresistive hysteresis values of the sensor are less than 21.7% and 6.8%, respectively. The initial resistance change is found to be within 4% after the first loading cycle. To reduce the interference among the sensing points, we also propose a structure where the grooves are inserted between the adjacent electrodes. This structure is implemented during the molding process, which is adopted to extend the porous tactile sensor to large-scale and facile fabrication. The effects of the structure are investigated with respect to the normalized design parameters ΘD, ΘW, and ΘT in a simulation, and the result is validated for samples with the same design parameters. An indentation experiment also shows that the structure designed for interference reduction effectively attenuates the interference of the sensor array, indicating that the spatial resolution of the sensor array is improved. As a result, the sensor can exhibit low hysteresis and low interference simultaneously. This research can be used for many applications, such as robotic skin, grippers, and wearable devices.

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DOI [BibTex]

DOI [BibTex]


Cognitive Prostheses for Goal Achievement
Cognitive Prostheses for Goal Achievement

Lieder, F., Chen, O. X., Krueger, P. M., Griffiths, T. L.

Nature Human Behavior, 3, August 2019 (article)

Abstract
Procrastination and impulsivity take a significant toll on people’s lives and the economy at large. Both can result from the misalignment of an action's proximal rewards with its long-term value. Therefore, aligning immediate reward with long-term value could be a way to help people overcome motivational barriers and make better decisions. Previous research has shown that game elements, such as points, levels, and badges, can be used to motivate people and nudge their decisions on serious matters. Here, we develop a new approach to decision support that leveragesartificial intelligence and game elements to restructure challenging sequential decision problems in such a way that it becomes easier for people to take the right course of action. A series of four increasingly more realistic experiments suggests that this approach can enable people to make better decisions faster, procrastinate less, complete their work on time, and waste less time on unimportant tasks. These findings suggest that our method is a promising step towards developing cognitive prostheses that help people achieve their goals by enhancing their motivation and decision-making in everyday life.

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DOI [BibTex]

DOI [BibTex]


Superior Magnetic Performance in FePt L1_0 Nanomaterials
Superior Magnetic Performance in FePt L1_0 Nanomaterials

Son, K., Ryu, G. H., Jeong, H., Fink, L., Merz, M., Nagel, P., Schuppler, S., Richter, G., Goering, E., Schütz, G.

Small, 15(1902353), July 2019 (article)

Abstract
The discovery of the high maximum energy product of 59 MGOe for NdFeB magnets is a breakthrough in the development of permanent magnets with a tremendous impact in many fields of technology. This value is still the world record, for 40 years. This work reports on a reliable and robust route to realize nearly perfectly ordered L1_0-phase FePt nanoparticles, leading to an unprecedented energy product of 80 MGOe at room temperature. Furthermore, with a 3 nm Au coverage, the magnetic polarization of these nanomagnets can be enhanced by 25% exceeding 1.8 T. This exceptional magnetization and anisotropy is confirmed by using multiple imaging and spectroscopic methods, which reveal highly consistent results. Due to the unprecedented huge energy product, this material can be envisaged as a new advanced basic magnetic component in modern micro and nanosized devices.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Lamination parameter interpolation method for design of manufacturable variable-stiffness composite panels

Serhat, G., Basdogan, I.

AIAA Journal, 57(7):3052–3065, July 2019 (article)

Abstract
Variable-stiffness laminates have lately drawn attention because they offer potential for additional structural performance improvements. In the optimization studies, laminate stiffness properties can be described efficiently by using lamination parameters, which is a well-established formulation for constant-stiffness laminates. However, ensuring manufacturability in the design of variable-stiffness laminates with lamination parameters is difficult. In this paper, a novel method for the design of variable-stiffness composite panels using lamination parameters is proposed. The method constrains the design space by controlling the magnitude and direction of change for the lamination parameters, and subsequently leads to a smooth change in the fiber angles. The method is used to maximize the fundamental frequencies of several panels as example cases. The solutions are calculated for various panel geometries and boundary conditions using the developed finite element analysis software. After finding optimal lamination parameter distributions, corresponding discrete fiber angles and fiber paths are retrieved, and the minimum radii of curvature are calculated. The results demonstrate that the proposed design method provides manufacturable smooth fiber paths while using the compact stiffness formulation feature of lamination parameters.

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DOI [BibTex]


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Physical activity in non-ambulatory toddlers with cerebral palsy

M.Orlando, J., Pierce, S., Mohan, M., Skorup, J., Paremski, A., Bochnak, M., Prosser, L. A.

Research in Developmental Disabilities, 90, pages: 51-58, July 2019 (article)

Abstract
Background: Children with cerebral palsy are less likely to be physically active than their peers, however there is limited evidence regarding self-initiated physical activity in toddlers who are not able, or who may never be able, to walk. Aims: The aim of this study was to measure self-initiated physical activity and its relationship to gross motor function and participation in non-ambulatory toddlers with cerebral palsy. Methods and procedures: Participants were between the ages of 1–3 years. Physical activity during independent floor-play at home was recorded using a wearable tri-axial accelerometer worn on the child’s thigh. The Gross Motor Function Measure-66 and the Child Engagement in Daily Life, a parent-reported questionnaire of participation, were administered. Outcomes and results: Data were analyzed from the twenty participants who recorded at least 90 min of floor-play (mean: 229 min), resulting in 4598 total floor-play minutes. The relationship between physical activity and gross motor function was not statistically significant (r = 0.20; p = 0.39), nor were the relationships between physical activity and participation (r = 0.05−0.09; p = 0.71−0.84). Conclusions and implications: The results suggest physical activity during floor-play is not related to gross motor function or participation in non-ambulatory toddlers with cerebral palsy. Clinicians and researchers should independently measure physical activity, gross motor function, and participation.

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DOI [BibTex]

DOI [BibTex]


Implementation of a 6-{DOF} Parallel Continuum Manipulator for Delivering Fingertip Tactile Cues
Implementation of a 6-DOF Parallel Continuum Manipulator for Delivering Fingertip Tactile Cues

Young, E. M., Kuchenbecker, K. J.

IEEE Transactions on Haptics, 12(3):295-306, June 2019 (article)

Abstract
Existing fingertip haptic devices can deliver different subsets of tactile cues in a compact package, but we have not yet seen a wearable six-degree-of-freedom (6-DOF) display. This paper presents the Fuppeteer (short for Fingertip Puppeteer), a device that is capable of controlling the position and orientation of a flat platform, such that any combination of normal and shear force can be delivered at any location on any human fingertip. We build on our previous work of designing a parallel continuum manipulator for fingertip haptics by presenting a motorized version in which six flexible Nitinol wires are actuated via independent roller mechanisms and proportional-derivative controllers. We evaluate the settling time and end-effector vibrations observed during system responses to step inputs. After creating a six-dimensional lookup table and adjusting simulated inputs using measured Jacobians, we show that the device can make contact with all parts of the fingertip with a mean error of 1.42 mm. Finally, we present results from a human-subject study. A total of 24 users discerned 9 evenly distributed contact locations with an average accuracy of 80.5%. Translational and rotational shear cues were identified reasonably well near the center of the fingertip and more poorly around the edges.

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DOI Project Page [BibTex]


Recent advances in gold nanoparticles forbiomedical applications: from hybrid structuresto multi-functionality
Recent advances in gold nanoparticles forbiomedical applications: from hybrid structuresto multi-functionality

Jeong, H., Choi, E., Ellis, E., Lee, T.

J. of Mat. Chem. B, 7, pages: 3480, May 2019 (article)

Abstract
Gold nanoparticles (Au NPs) are arguably the most versatile nanomaterials reported to date. Recentadvances in nanofabrication and chemical synthesis have expanded the scope of Au NPs from classicalhomogeneous nanospheres to a wide range of hybrid nanostructures with programmable size, shapeand composition. Novel physiochemical properties can be achievedviadesign and engineering of thehybrid nanostructures. In this review we discuss the recent progress in the development of complexhybrid Au NPs and propose a classification framework based on three fundamental structuraldimensions (length scale, complexity and symmetry) to aid categorising, comparing and designingvarious types of Au NPs. Their novel functions and potential for biomedical applications will also bediscussed, featuring point-of-care diagnostics by advanced optical spectroscopy and assays, as well asminimally invasive surgeries and targeted drug delivery using multifunctional nano-robot

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link (url) DOI [BibTex]


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How Does It Feel to Clap Hands with a Robot?

Fitter, N. T., Kuchenbecker, K. J.

International Journal of Social Robotics, 12(1):113-127, April 2019 (article)

Abstract
Future robots may need lighthearted physical interaction capabilities to connect with people in meaningful ways. To begin exploring how users perceive playful human–robot hand-to-hand interaction, we conducted a study with 20 participants. Each user played simple hand-clapping games with the Rethink Robotics Baxter Research Robot during a 1-h-long session involving 24 randomly ordered conditions that varied in facial reactivity, physical reactivity, arm stiffness, and clapping tempo. Survey data and experiment recordings demonstrate that this interaction is viable: all users successfully completed the experiment and mentioned enjoying at least one game without prompting. Hand-clapping tempo was highly salient to users, and human-like robot errors were more widely accepted than mechanical errors. Furthermore, perceptions of Baxter varied in the following statistically significant ways: facial reactivity increased the robot’s perceived pleasantness and energeticness; physical reactivity decreased pleasantness, energeticness, and dominance; higher arm stiffness increased safety and decreased dominance; and faster tempo increased energeticness and increased dominance. These findings can motivate and guide roboticists who want to design social–physical human–robot interactions.

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DOI [BibTex]

DOI [BibTex]


Self-Assembled Phage-Based Colloids for High Localized Enzymatic Activity
Self-Assembled Phage-Based Colloids for High Localized Enzymatic Activity

Alarcon-Correa, M., Guenther, J., Troll, J., Kadiri, V. M., Bill, J., Fischer, P., Rothenstein, D.

ACS Nano, 13, pages: 5810–5815, March 2019 (article)

Abstract
Catalytically active colloids are model systems for chemical motors and active matter. It is desirable to replace the inorganic catalysts and the toxic fuels that are often used, with biocompatible enzymatic reactions. However, compared to inorganic catalysts, enzyme-coated colloids tend to exhibit less activity. Here, we show that the self-assembly of genetically engineered M13 bacteriophages that bind enzymes to magnetic beads ensures high and localized enzymatic activity. These phage-decorated colloids provide a proteinaceous environment for directed enzyme immobilization. The magnetic properties of the colloidal carrier particle permit repeated enzyme recovery from a reaction solution, while the enzymatic activity is retained. Moreover, localizing the phage-based construct with a magnetic field in a microcontainer allows the enzyme-phage-colloids to function as an enzymatic micropump, where the enzymatic reaction generates a fluid flow. This system shows the fastest fluid flow reported to date by a biocompatible enzymatic micropump. In addition, it is functional in complex media including blood where the enzyme driven micropump can be powered at the physiological blood-urea concentration.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


Absolute diffusion measurements of active enzyme solutions by NMR
Absolute diffusion measurements of active enzyme solutions by NMR

Guenther, J., Majer, G., Fischer, P.

J. Chem. Phys., 150(124201), March 2019 (article)

Abstract
The diffusion of enzymes is of fundamental importance for many biochemical processes. Enhanced or directed enzyme diffusion can alter the accessibility of substrates and the organization of enzymes within cells. Several studies based on fluorescence correlation spectroscopy (FCS) report enhanced diffusion of enzymes upon interaction with their substrate or inhibitor. In this context, major importance is given to the enzyme fructose-bisphosphate aldolase, for which enhanced diffusion has been reported even though the catalysed reaction is endothermic. Additionally, enhanced diffusion of tracer particles surrounding the active aldolase enzymes has been reported. These studies suggest that active enzymes can act as chemical motors that self-propel and give rise to enhanced diffusion. However, fluorescence studies of enzymes can, despite several advantages, suffer from artefacts. Here we show that the absolute diffusion coefficients of active enzyme solutions can be determined with Pulsed Field Gradient Nuclear Magnetic Resonance (PFG-NMR). The advantage of PFG-NMR is that the motion of the molecule of interest is directly observed in its native state without the need for any labelling. Further, PFG-NMR is model-free and thus yields absolute diffusion constants. Our PFG-NMR experiments of solutions containing active fructose-bisphosphate aldolase from rabbit muscle do not show any diffusion enhancement for the active enzymes nor the surrounding molecules. Additionally, we do not observe any diffusion enhancement of aldolase in the presence of its inhibitor pyrophosphate.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


Chemical Nanomotors at the Gram Scale Form a Dense Active Optorheological Medium
Chemical Nanomotors at the Gram Scale Form a Dense Active Optorheological Medium

Choudhury, U., Singh, D. P., Qiu, T., Fischer, P.

Adv. Mat., 31(1807382), Febuary 2019 (article)

Abstract
The rheological properties of a colloidal suspension are a function of the concentration of the colloids and their interactions. While suspensions of passive colloids are well studied and have been shown to form crystals, gels, and glasses, examples of energy‐consuming “active” colloidal suspensions are still largely unexplored. Active suspensions of biological matter, such as motile bacteria or dense mixtures of active actin–motor–protein mixtures have, respectively, reveals superfluid‐like and gel‐like states. Attractive inanimate systems for active matter are chemically self‐propelled particles. It has so far been challenging to use these swimming particles at high enough densities to affect the bulk material properties of the suspension. Here, it is shown that light‐triggered asymmetric titanium dioxide that self‐propel, can be obtained in large quantities, and self‐organize to make a gram‐scale active medium. The suspension shows an activity‐dependent tenfold reversible change in its bulk viscosity.

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link (url) DOI [BibTex]


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Resource-rational analysis: Understanding human cognition as the optimal use of limited computational resources

Lieder, F., Griffiths, T. L.

Behavioral and Brain Sciences, 43, E1, Febuary 2019 (article)

Abstract
Modeling human cognition is challenging because there are infinitely many mechanisms that can generate any given observation. Some researchers address this by constraining the hypothesis space through assumptions about what the human mind can and cannot do, while others constrain it through principles of rationality and adaptation. Recent work in economics, psychology, neuroscience, and linguistics has begun to integrate both approaches by augmenting rational models with cognitive constraints, incorporating rational principles into cognitive architectures, and applying optimality principles to understanding neural representations. We identify the rational use of limited resources as a unifying principle underlying these diverse approaches, expressing it in a new cognitive modeling paradigm called resource-rational analysis. The integration of rational principles with realistic cognitive constraints makes resource-rational analysis a promising framework for reverse-engineering cognitive mechanisms and representations. It has already shed new light on the debate about human rationality and can be leveraged to revisit classic questions of cognitive psychology within a principled computational framework. We demonstrate that resource-rational models can reconcile the mind's most impressive cognitive skills with people's ostensive irrationality. Resource-rational analysis also provides a new way to connect psychological theory more deeply with artificial intelligence, economics, neuroscience, and linguistics.

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DOI [BibTex]

DOI [BibTex]


First Observation of Optical Activity in Hyper-Rayleigh Scattering
First Observation of Optical Activity in Hyper-Rayleigh Scattering

Collins, J., Rusimova, K., Hooper, D., Jeong, H. H., Ohnoutek, L., Pradaux-Caggiano, F., Verbiest, T., Carbery, D., Fischer, P., Valev, V.

Phys. Rev. X, 9(011024), January 2019 (article)

Abstract
Chiral nano- or metamaterials and surfaces enable striking photonic properties, such as negative refractive index and superchiral light, driving promising applications in novel optical components, nanorobotics, and enhanced chiral molecular interactions with light. In characterizing chirality, although nonlinear chiroptical techniques are typically much more sensitive than their linear optical counterparts, separating true chirality from anisotropy is a major challenge. Here, we report the first observation of optical activity in second-harmonic hyper-Rayleigh scattering (HRS). We demonstrate the effect in a 3D isotropic suspension of Ag nanohelices in water. The effect is 5 orders of magnitude stronger than linear optical activity and is well pronounced above the multiphoton luminescence background. Because of its sensitivity, isotropic environment, and straightforward experimental geometry, HRS optical activity constitutes a fundamental experimental breakthrough in chiral photonics for media including nanomaterials, metamaterials, and chemical molecules.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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The Perception of Ultrasonic Square Reductions of Friction With Variable Sharpness and Duration

Gueorguiev, D., Vezzoli, E., Sednaoui, T., Grisoni, L., Lemaire-Semail, B.

IEEE Transactions on Haptics, 12(2):179-188, January 2019 (article)

Abstract
The human perception of square ultrasonic modulation of the finger-surface friction was investigated during active tactile exploration by using short frictional cues of varying duration and sharpness. In a first experiment, we asked participants to discriminate the transition time and duration of short square ultrasonic reductions of friction. They proved very sensitive to discriminate millisecond differences in these two parameters with the average psychophysical thresholds being 2.3–2.4 ms for both parameters. A second experiment focused on the perception of square friction reductions with variable transition times and durations. We found that for durations of the stimulation larger than 90 ms, participants often perceived three or four edges when only two stimulations were presented while they consistently felt two edges for signals shorter than 50 ms. A subsequent analysis of the contact forces induced by these ultrasonic stimulations during slow and fast active exploration showed that two identical consecutive ultrasonic pulses can induce significantly different frictional dynamics especially during fast motion of the finger. These results confirm the human sensitivity to transient frictional cues and suggest that the human perception of square reductions of friction can depend on their sharpness and duration as well as on the speed of exploration.

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DOI [BibTex]

DOI [BibTex]


Tactile Roughness Perception of Virtual Gratings by Electrovibration
Tactile Roughness Perception of Virtual Gratings by Electrovibration

Isleyen, A., Vardar, Y., Basdogan, C.

IEEE Transactions on Haptics, 2019 (article) Accepted

hi

[BibTex]

[BibTex]


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Co-Contraction facilitates Body Stiffness Modulation during Swimming with Sensory Feedback in a Soft Biorobotic Physical Model

Jusufi, A., Vogt, D., Wood, R. J.

Integrative and Comparative Biology, 59(Supplement 1):E116-E116, Society of Integrative and Comparative Biology, McLean, VA, 2019 (article)

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DOI [BibTex]

DOI [BibTex]


A Rational Reinterpretation of Dual Process Theories
A Rational Reinterpretation of Dual Process Theories

Milli, S., Lieder, F., Griffiths, T. L.

2019 (article)

Abstract
Highly influential "dual-process" accounts of human cognition postulate the coexistence of a slow accurate system with a fast error-prone system. But why would there be just two systems rather than, say, one or 93? Here, we argue that a dual-process architecture might be neither arbitrary nor irrational, but might instead reflect a rational tradeoff between the cognitive flexibility afforded by multiple systems and the time and effort required to choose between them. We investigate what the optimal set and number of cognitive systems would be depending on the structure of the environment. We find that the optimal number of systems depends on the variability of the environment and the difficulty of deciding when which system should be used. Furthermore, when having two systems is optimal, then the first system is fast but error-prone and the second system is slow but accurate. Our findings thereby provide a rational reinterpretation of dual-process theories.

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DOI [BibTex]

DOI [BibTex]

2017


Active colloidal propulsion over a crystalline surface
Active colloidal propulsion over a crystalline surface

Choudhury, U., Straube, A., Fischer, P., Gibbs, J., Höfling, F.

New Journal of Physics, 19, pages: 125010, December 2017 (article)

Abstract
We study both experimentally and theoretically the dynamics of chemically self-propelled Janus colloids moving atop a two-dimensional crystalline surface. The surface is a hexagonally close-packed monolayer of colloidal particles of the same size as the mobile one. The dynamics of the self-propelled colloid reflects the competition between hindered diffusion due to the periodic surface and enhanced diffusion due to active motion. Which contribution dominates depends on the propulsion strength, which can be systematically tuned by changing the concentration of a chemical fuel. The mean-square displacements obtained from the experiment exhibit enhanced diffusion at long lag times. Our experimental data are consistent with a Langevin model for the effectively two-dimensional translational motion of an active Brownian particle in a periodic potential, combining the confining effects of gravity and the crystalline surface with the free rotational diffusion of the colloid. Approximate analytical predictions are made for the mean-square displacement describing the crossover from free Brownian motion at short times to active diffusion at long times. The results are in semi-quantitative agreement with numerical results of a refined Langevin model that treats translational and rotational degrees of freedom on the same footing.

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link (url) DOI [BibTex]

2017


link (url) DOI [BibTex]


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Evaluation of High-Fidelity Simulation as a Training Tool in Transoral Robotic Surgery

Bur, A. M., Gomez, E. D., Newman, J. G., Weinstein, G. S., Bert W. O’Malley, J., Rassekh, C. H., Kuchenbecker, K. J.

Laryngoscope, 127(12):2790-2795, December 2017 (article)

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DOI [BibTex]

DOI [BibTex]


Wireless Acoustic-Surface Actuators for Miniaturized Endoscopes
Wireless Acoustic-Surface Actuators for Miniaturized Endoscopes

Qiu, T., Adams, F., Palagi, S., Melde, K., Mark, A. G., Wetterauer, U., Miernik, A., Fischer, P.

ACS Applied Materials & Interfaces, 9(49):42536 - 42543, November 2017 (article)

Abstract
Endoscopy enables minimally invasive procedures in many medical fields, such as urology. However, current endoscopes are normally cable-driven, which limits their dexterity and makes them hard to miniaturize. Indeed current urological endoscopes have an outer diameter of about 3 mm and still only possess one bending degree of freedom. In this paper, we report a novel wireless actuation mechanism that increases the dexterity and that permits the miniaturization of a urological endoscope. The novel actuator consists of thin active surfaces that can be readily attached to any device and are wirelessly powered by ultrasound. The surfaces consist of two-dimensional arrays of micro-bubbles, which oscillate under ultrasound excitation and thereby generate an acoustic streaming force. Bubbles of different sizes are addressed by their unique resonance frequency, thus multiple degrees of freedom can readily be incorporated. Two active miniaturized devices (with a side length of around 1 mm) are demonstrated: a miniaturized mechanical arm that realizes two degrees of freedom, and a flexible endoscope prototype equipped with a camera at the tip. With the flexible endoscope, an active endoscopic examination is successfully performed in a rabbit bladder. This results show the potential medical applicability of surface actuators wirelessly powered by ultrasound penetrating through biological tissues.

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link (url) DOI Project Page [BibTex]

link (url) DOI Project Page [BibTex]


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Strategy selection as rational metareasoning

Lieder, F., Griffiths, T. L.

Psychological Review, 124, pages: 762-794, American Psychological Association, November 2017 (article)

Abstract
Many contemporary accounts of human reasoning assume that the mind is equipped with multiple heuristics that could be deployed to perform a given task. This raises the question of how the mind determines when to use which heuristic. To answer this question, we developed a rational model of strategy selection, based on the theory of rational metareasoning developed in the artificial intelligence literature. According to our model people learn to efficiently choose the strategy with the best cost–benefit tradeoff by learning a predictive model of each strategy’s performance. We found that our model can provide a unifying explanation for classic findings from domains ranging from decision-making to arithmetic by capturing the variability of people’s strategy choices, their dependence on task and context, and their development over time. Systematic model comparisons supported our theory, and 4 new experiments confirmed its distinctive predictions. Our findings suggest that people gradually learn to make increasingly more rational use of fallible heuristics. This perspective reconciles the 2 poles of the debate about human rationality by integrating heuristics and biases with learning and rationality. (APA PsycInfo Database Record (c) 2017 APA, all rights reserved)

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DOI Project Page [BibTex]

DOI Project Page [BibTex]


Electrically tunable binary phase Fresnel lens based on a dielectric elastomer actuator
Electrically tunable binary phase Fresnel lens based on a dielectric elastomer actuator

Park, S., Park, B., Nam, S., Yun, S., Park, S. K., Mun, S., Lim, J. M., Ryu, Y., Song, S. H., Kyung, K.

Optics Express, 25(20):23801-23808, OSA, October 2017 (article)

Abstract
We propose and demonstrate an all-solid-state tunable binary phase Fresnel lens with electrically controllable focal length. The lens is composed of a binary phase Fresnel zone plate, a circular acrylic frame, and a dielectric elastomer (DE) actuator which is made of a thin DE layer and two compliant electrodes using silver nanowires. Under electric potential, the actuator produces in-plane deformation in a radial direction that can compress the Fresnel zones. The electrically-induced deformation compresses the Fresnel zones to be contracted as high as 9.1 % and changes the focal length, getting shorter from 20.0 cm to 14.5 cm. The measured change in the focal length of the fabricated lens is consistent with the result estimated from numerical simulation.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


Active Acoustic Surfaces Enable the Propulsion of a Wireless Robot
Active Acoustic Surfaces Enable the Propulsion of a Wireless Robot

Qiu, T., Palagi, S., Mark, A. G., Melde, K., Adams, F., Fischer, P.

Advanced Materials Interfaces, 4(21):1700933, September 2017 (article)

Abstract
A major challenge that prevents the miniaturization of mechanically actuated systems is the lack of suitable methods that permit the efficient transfer of power to small scales. Acoustic energy holds great potential, as it is wireless, penetrates deep into biological tissues, and the mechanical vibrations can be directly converted into directional forces. Recently, active acoustic surfaces are developed that consist of 2D arrays of microcavities holding microbubbles that can be excited with an external acoustic field. At resonance, the surfaces give rise to acoustic streaming and thus provide a highly directional propulsive force. Here, this study advances these wireless surface actuators by studying their force output as the size of the bubble-array is increased. In particular, a general method is reported to dramatically improve the propulsive force, demonstrating that the surface actuators are actually able to propel centimeter-scale devices. To prove the flexibility of the functional surfaces as wireless ready-to-attach actuator, a mobile mini-robot capable of propulsion in water along multiple directions is presented. This work paves the way toward effectively exploiting acoustic surfaces as a novel wireless actuation scheme at small scales.

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link (url) DOI Project Page [BibTex]


Corrosion-Protected Hybrid Nanoparticles
Corrosion-Protected Hybrid Nanoparticles

Jeong, H. H., Alarcon-Correa, M., Mark, A. G., Son, K., Lee, T., Fischer, P.

Advanced Science, 4(12):1700234, September 2017 (article)

Abstract
Nanoparticles composed of functional materials hold great promise for applications due to their unique electronic, optical, magnetic, and catalytic properties. However, a number of functional materials are not only difficult to fabricate at the nanoscale, but are also chemically unstable in solution. Hence, protecting nanoparticles from corrosion is a major challenge for those applications that require stability in aqueous solutions and biological fluids. Here, this study presents a generic scheme to grow hybrid 3D nanoparticles that are completely encapsulated by a nm thick protective shell. The method consists of vacuum-based growth and protection, and combines oblique physical vapor deposition with atomic layer deposition. It provides wide flexibility in the shape and composition of the nanoparticles, and the environments against which particles are protected. The work demonstrates the approach with multifunctional nanoparticles possessing ferromagnetic, plasmonic, and chiral properties. The present scheme allows nanocolloids, which immediately corrode without protection, to remain functional, at least for a week, in acidic solutions.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Using Contact Forces and Robot Arm Accelerations to Automatically Rate Surgeon Skill at Peg Transfer

Brown, J. D., O’Brien, C. E., Leung, S. C., Dumon, K. R., Lee, D. I., Kuchenbecker, K. J.

IEEE Transactions on Biomedical Engineering, 64(9):2263-2275, September 2017 (article)

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Ungrounded Haptic Augmented Reality System for Displaying Texture and Friction

Culbertson, H., Kuchenbecker, K. J.

IEEE/ASME Transactions on Mechatronics, 22(4):1839-1849, August 2017 (article)

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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A variation in wrinkle structures of UV-cured films with chemical structures of prepolymers

Park, S. K., Kwark, Y., Nam, S., Moon, J., Kim, D. W., Park, S., Park, B., Yun, S., Lee, J., Yu, B., Kyung, K.

Materials Letters, 199, pages: 105-109, July 2017 (article)

Abstract
Spontaneously wrinkled films can be easily obtained from UV-crosslinkable liquid prepolymers under special UV-curing conditions. They vary wrinkle structures of the UV-cured films and, however, cannot be precisely controlled. Here, five different UV-crosslinkable prepolymers are synthesized to study the chemical structure effect of prepolymers on wrinkle formation and modulation of the UV-cured films irrespective of the UV-curing conditions. Both wavelength and amplitude of the wrinkles are tuned with the different liquid prepolymers from 4.10 to 5.63µm and from 1.00 to 1.66µm, respectively. The wrinkle structures of the UV-cured films are faded by adding a solid prepolymer to a liquid prepolymer due to interference from it in the shrinkage of the liquid prepolymer layer. The wrinkles completely disappear in the UV-cured films fabricated from the formulated prepolymers containing over 50wt% of the solid prepolymer.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


Non-Equilibrium Assembly of Light-Activated Colloidal Mixtures
Non-Equilibrium Assembly of Light-Activated Colloidal Mixtures

Singh, D. P., Choudhury, U., Fischer, P., Mark, A. G.

Advanced Materials, 29, pages: 1701328, June 2017, 32 (article)

Abstract
The collective phenomena exhibited by artificial active matter systems present novel routes to fabricating out-of-equilibrium microscale assemblies. Here, the crystallization of passive silica colloids into well-controlled 2D assemblies is shown, which is directed by a small number of self-propelled active colloids. The active colloids are titania–silica Janus particles that are propelled when illuminated by UV light. The strength of the attractive interaction and thus the extent of the assembled clusters can be regulated by the light intensity. A remarkably small number of the active colloids is sufficient to induce the assembly of the dynamic crystals. The approach produces rationally designed colloidal clusters and crystals with controllable sizes, shapes, and symmetries. This multicomponent active matter system offers the possibility of obtaining structures and assemblies that cannot be found in equilibrium systems.

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link (url) DOI [BibTex]


Nanodiamonds That Swim
Nanodiamonds That Swim

Kim, J. T., Choudhury, U., Hyeon-Ho, J., Fischer, P.

Advanced Materials, 29(30):1701024, June 2017, Back Cover (article)

Abstract
Nanodiamonds are emerging as nanoscale quantum probes for bio-sensing and imaging. This necessitates the development of new methods to accurately manipulate their position and orientation in aqueous solutions. The realization of an “active” nanodiamond (ND) swimmer in fluids, composed of a ND crystal containing nitrogen vacancy centers and a light-driven self-thermophoretic micromotor, is reported. The swimmer is propelled by a local temperature gradient created by laser illumination on its metal-coated side. Its locomotion—from translational to rotational motion—is successfully controlled by shape-dependent hydrodynamic interactions. The precise engineering of the swimmer's geometry is achieved by self-assembly combined with physical vapor shadow growth. The optical addressability of the suspended ND swimmers is demonstrated by observing the electron spin resonance in the presence of magnetic fields. Active motion at the nanoscale enables new sensing capabilities combined with active transport including, potentially, in living organisms.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Perception of Force and Stiffness in the Presence of Low-Frequency Haptic Noise

Gurari, N., Okamura, A. M., Kuchenbecker, K. J.

PLoS ONE, 12(6):e0178605, June 2017 (article)

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Evaluation of a Vibrotactile Simulator for Dental Caries Detection

Kuchenbecker, K. J., Parajon, R., Maggio, M. P.

Simulation in Healthcare, 12(3):148-156, June 2017 (article)

hi

DOI [BibTex]

DOI [BibTex]


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Empirical Evidence for Resource-Rational Anchoring and Adjustment

Lieder, F., Griffiths, T. L., Huys, Q. J. M., Goodman, N. D.

Psychonomic Bulletin \& Review, 25, pages: 775-784, Springer, May 2017 (article)

Abstract
People’s estimates of numerical quantities are systematically biased towards their initial guess. This anchoring bias is usually interpreted as sign of human irrationality, but it has recently been suggested that the anchoring bias instead results from people’s rational use of their finite time and limited cognitive resources. If this were true, then adjustment should decrease with the relative cost of time. To test this hypothesis, we designed a new numerical estimation paradigm that controls people’s knowledge and varies the cost of time and error independently while allowing people to invest as much or as little time and effort into refining their estimate as they wish. Two experiments confirmed the prediction that adjustment decreases with time cost but increases with error cost regardless of whether the anchor was self-generated or provided. These results support the hypothesis that people rationally adapt their number of adjustments to achieve a near-optimal speed-accuracy tradeoff. This suggests that the anchoring bias might be a signature of the rational use of finite time and limited cognitive resources rather than a sign of human irrationality.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


Soft 3D-Printed Phantom of the Human Kidney with Collecting System
Soft 3D-Printed Phantom of the Human Kidney with Collecting System

Adams, F., Qiu, T., Mark, A., Fritz, B., Kramer, L., Schlager, D., Wetterauer, U., Miernik, A., Fischer, P.

Ann. of Biomed. Eng., 45(4):963-972, April 2017 (article)

Abstract
Organ models are used for planning and simulation of operations, developing new surgical instruments, and training purposes. There is a substantial demand for in vitro organ phantoms, especially in urological surgery. Animal models and existing simulator systems poorly mimic the detailed morphology and the physical properties of human organs. In this paper, we report a novel fabrication process to make a human kidney phantom with realistic anatomical structures and physical properties. The detailed anatomical structure was directly acquired from high resolution CT data sets of human cadaveric kidneys. The soft phantoms were constructed using a novel technique that combines 3D wax printing and polymer molding. Anatomical details and material properties of the phantoms were validated in detail by CT scan, ultrasound, and endoscopy. CT reconstruction, ultrasound examination, and endoscopy showed that the designed phantom mimics a real kidney's detailed anatomy and correctly corresponds to the targeted human cadaver's upper urinary tract. Soft materials with a tensile modulus of 0.8-1.5 MPa as well as biocompatible hydrogels were used to mimic human kidney tissues. We developed a method of constructing 3D organ models from medical imaging data using a 3D wax printing and molding process. This method is cost-effective means for obtaining a reproducible and robust model suitable for surgical simulation and training purposes.

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DOI Project Page [BibTex]

DOI Project Page [BibTex]


Pattern formation and collective effects in populations of magnetic microswimmers
Pattern formation and collective effects in populations of magnetic microswimmers

Vach, P. J., (Walker) Schamel, D., Fischer, P., Fratzl, P., Faivre, D.

J. of Phys. D: Appl. Phys., 50(11):11LT03, Febuary 2017 (article)

Abstract
Self-propelled particles are one prototype of synthetic active matter used to understand complex biological processes, such as the coordination of movement in bacterial colonies or schools of fishes. Collective patterns such as clusters were observed for such systems, reproducing features of biological organization. However, one limitation of this model is that the synthetic assemblies are made of identical individuals. Here we introduce an active system based on magnetic particles at colloidal scales. We use identical but also randomly-shaped magnetic micropropellers and show that they exhibit dynamic and reversible pattern formation.

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DOI [BibTex]

DOI [BibTex]


On-chip enzymatic microbiofuel cell-powered integrated circuits
On-chip enzymatic microbiofuel cell-powered integrated circuits

Mark, A. G., Suraniti, E., Roche, J., Richter, H., Kuhn, A., Mano, N., Fischer, P.

Lab on a Chip, 17(10):1761-1768, Febuary 2017, Recent HOT Article (article)

Abstract
A variety of diagnostic and therapeutic medical technologies rely on long term implantation of an electronic device to monitor or regulate a patient's condition. One proposed approach to powering these devices is to use a biofuel cell to convert the chemical energy from blood nutrients into electrical current to supply the electronics. We present here an enzymatic microbiofuel cell whose electrodes are directly integrated into a digital electronic circuit. Glucose oxidizing and oxygen reducing enzymes are immobilized on microelectrodes of an application specific integrated circuit (ASIC) using redox hydrogels to produce an enzymatic biofuel cell, capable of harvesting electrical power from just a single droplet of 5 mM glucose solution. Optimisation of the fuel cell voltage and power to match the requirements of the electronics allow self-powered operation of the on-board digital circuitry. This study represents a step towards implantable self-powered electronic devices that gather their energy from physiological fluids.

Recent HOT Article.

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DOI [BibTex]

DOI [BibTex]


Strong Rotational Anisotropies Affect Nonlinear Chiral Metamaterials
Strong Rotational Anisotropies Affect Nonlinear Chiral Metamaterials

Hooper, D. C., Mark, A. G., Kuppe, C., Collins, J. T., Fischer, P., Valev, V. K.

Advanced Materials, 29(13):1605110, January 2017 (article)

Abstract
Masked by rotational anisotropies, the nonlinear chiroptical response of a metamaterial is initially completely inaccessible. Upon rotating the sample the chiral information emerges. These results highlight the need for a general method to extract the true chiral contributions to the nonlinear optical signal, which would be hugely valuable in the present context of increasingly complex chiral meta/nanomaterials.

pf

DOI [BibTex]

DOI [BibTex]