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2004


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Analysis of differential gene expression in healthy and osteoarthritic cartilage and isolated chondrocytes by microarray analysis

Aigner, T., Saas, J., Zien, A., Zimmer, R., Gebhard, P., Knorr, T.

In Volume 1: Cellular and Molecular Tools, pages: 109-128, (Editors: Sabatini, M., P. Pastoureau and F. De Ceuninck), Humana Press, July 2004 (inbook)

Abstract
The regulation of chondrocytes in osteoarthritic cartilage and the expression of specific gene products by these cells during early-onset and late-stage osteoarthritis are not well characterized. With the introduction of cDNA array technology, the measurement of thousands of different genes in one small tissue sample can be carried out. Interpretation of gene expression analyses in articular cartilage is aided by the fact that this tissue contains only one cell type in both normal and diseased conditions. However, care has to be taken not to over- and misinterpret results, and some major challenges must be overcome in order to utilize the potential of this technology properly in the field of osteoarthritis.

ei

Web [BibTex]

2004


Web [BibTex]


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Distributed Command Execution

Stark, S., Berlin, M.

In BSD Hacks: 100 industrial-strength tips & tools, pages: 152-152, (Editors: Lavigne, Dru), O’Reilly, Beijing, May 2004 (inbook)

Abstract
Often you want to execute a command not only on one computer, but on several at once. For example, you might want to report the current statistics on a group of managed servers or update all of your web servers at once.

ei

[BibTex]

[BibTex]


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Local Alignment Kernels for Biological Sequences

Vert, J., Saigo, H., Akutsu, T.

In Kernel Methods in Computational Biology, pages: 131-153, MIT Press, Cambridge, MA,, 2004 (inbook)

ei

Web [BibTex]

Web [BibTex]


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Gaussian Processes in Machine Learning

Rasmussen, CE.

In 3176, pages: 63-71, Lecture Notes in Computer Science, (Editors: Bousquet, O., U. von Luxburg and G. Rätsch), Springer, Heidelberg, 2004, Copyright by Springer (inbook)

Abstract
We give a basic introduction to Gaussian Process regression models. We focus on understanding the role of the stochastic process and how it is used to define a distribution over functions. We present the simple equations for incorporating training data and examine how to learn the hyperparameters using the marginal likelihood. We explain the practical advantages of Gaussian Process and end with conclusions and a look at the current trends in GP work.

ei

PDF PostScript [BibTex]

PDF PostScript [BibTex]


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Protein Classification via Kernel Matrix Completion

Kin, T., Kato, T., Tsuda, K.

In pages: 261-274, (Editors: Schoelkopf, B., K. Tsuda and J.P. Vert), MIT Press, Cambridge, MA; USA, 2004 (inbook)

ei

PDF [BibTex]

PDF [BibTex]


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Introduction to Statistical Learning Theory

Bousquet, O., Boucheron, S., Lugosi, G.

In Lecture Notes in Artificial Intelligence 3176, pages: 169-207, (Editors: Bousquet, O., U. von Luxburg and G. Rätsch), Springer, Heidelberg, Germany, 2004 (inbook)

ei

PDF [BibTex]

PDF [BibTex]


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A Primer on Kernel Methods

Vert, J., Tsuda, K., Schölkopf, B.

In Kernel Methods in Computational Biology, pages: 35-70, (Editors: B Schölkopf and K Tsuda and JP Vert), MIT Press, Cambridge, MA, USA, 2004 (inbook)

ei

PDF [BibTex]

PDF [BibTex]


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Concentration Inequalities

Boucheron, S., Lugosi, G., Bousquet, O.

In Lecture Notes in Artificial Intelligence 3176, pages: 208-240, (Editors: Bousquet, O., U. von Luxburg and G. Rätsch), Springer, Heidelberg, Germany, 2004 (inbook)

ei

PDF [BibTex]

PDF [BibTex]


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Kernels for graphs

Kashima, H., Tsuda, K., Inokuchi, A.

In pages: 155-170, (Editors: Schoelkopf, B., K. Tsuda and J.P. Vert), MIT Press, Cambridge, MA; USA, 2004 (inbook)

ei

PDF [BibTex]

PDF [BibTex]


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A primer on molecular biology

Zien, A.

In pages: 3-34, (Editors: Schoelkopf, B., K. Tsuda and J. P. Vert), MIT Press, Cambridge, MA, USA, 2004 (inbook)

Abstract
Modern molecular biology provides a rich source of challenging machine learning problems. This tutorial chapter aims to provide the necessary biological background knowledge required to communicate with biologists and to understand and properly formalize a number of most interesting problems in this application domain. The largest part of the chapter (its first section) is devoted to the cell as the basic unit of life. Four aspects of cells are reviewed in sequence: (1) the molecules that cells make use of (above all, proteins, RNA, and DNA); (2) the spatial organization of cells (``compartmentalization''); (3) the way cells produce proteins (``protein expression''); and (4) cellular communication and evolution (of cells and organisms). In the second section, an overview is provided of the most frequent measurement technologies, data types, and data sources. Finally, important open problems in the analysis of these data (bioinformatics challenges) are briefly outlined.

ei

PDF PostScript Web [BibTex]

PDF PostScript Web [BibTex]


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Development of neural motor prostheses for humans

Donoghue, J., Nurmikko, A., Friehs, G., Black, M.

In Advances in Clinical Neurophysiology, (Editors: Hallett, M. and Phillips, L.H. and Schomer, D.L. and Massey, J.M.), Supplements to Clinical Neurophysiology Vol. 57, 2004 (incollection)

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pdf [BibTex]

pdf [BibTex]


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Computational approaches to motor learning by imitation

Schaal, S., Ijspeert, A., Billard, A.

In The Neuroscience of Social Interaction, (1431):199-218, (Editors: Frith, C. D.;Wolpert, D.), Oxford University Press, Oxford, 2004, clmc (inbook)

Abstract
Movement imitation requires a complex set of mechanisms that map an observed movement of a teacher onto one's own movement apparatus. Relevant problems include movement recognition, pose estimation, pose tracking, body correspondence, coordinate transformation from external to egocentric space, matching of observed against previously learned movement, resolution of redundant degrees-of-freedom that are unconstrained by the observation, suitable movement representations for imitation, modularization of motor control, etc. All of these topics by themselves are active research problems in computational and neurobiological sciences, such that their combination into a complete imitation system remains a daunting undertaking - indeed, one could argue that we need to understand the complete perception-action loop. As a strategy to untangle the complexity of imitation, this paper will examine imitation purely from a computational point of view, i.e. we will review statistical and mathematical approaches that have been suggested for tackling parts of the imitation problem, and discuss their merits, disadvantages and underlying principles. Given the focus on action recognition of other contributions in this special issue, this paper will primarily emphasize the motor side of imitation, assuming that a perceptual system has already identified important features of a demonstrated movement and created their corresponding spatial information. Based on the formalization of motor control in terms of control policies and their associated performance criteria, useful taxonomies of imitation learning can be generated that clarify different approaches and future research directions.

am

link (url) [BibTex]

link (url) [BibTex]


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Effect of Grain Boundary Phase Transitions on the Superplasticity in the Al-Zn System

Lopez, G.A., Straumal, B.B., Gust, W., Mittemeijer, E.J.

In Nanomaterials by Severe Plastic Deformation, pages: 642-647, Wiley-VCH Verlag, Weinheim, 2004 (incollection)

mms

[BibTex]

[BibTex]

2001


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Extracting egomotion from optic flow: limits of accuracy and neural matched filters

Dahmen, H-J., Franz, MO., Krapp, HG.

In pages: 143-168, Springer, Berlin, 2001 (inbook)

ei

[BibTex]

2001


[BibTex]


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Influence of grain boundary phase transitions on the properties of Cu-Bi polycrystals

Straumal, B. B., Sluchanko, N.E., Gust, W.

In Defects and Diffusion in Metals III: An Annual Retrospective III, 188-1, pages: 185-194, Defect and Diffusion Forum, 2001 (incollection)

mms

[BibTex]

[BibTex]

1993


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Mixture models for optical flow computation

Jepson, A., Black, M.

In Partitioning Data Sets, DIMACS Workshop, pages: 271-286, (Editors: Ingemar Cox, Pierre Hansen, and Bela Julesz), AMS Pub, Providence, RI., April 1993 (incollection)

ps

pdf [BibTex]

1993


pdf [BibTex]


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Learning passive motor control strategies with genetic algorithms

Schaal, S., Sternad, D.

In 1992 Lectures in complex systems, pages: 913-918, (Editors: Nadel, L.;Stein, D.), Addison-Wesley, Redwood City, CA, 1993, clmc (inbook)

Abstract
This study investigates learning passive motor control strategies. Passive control is understood as control without active error correction; the movement is stabilized by particular properties of the controlling dynamics. We analyze the task of juggling a ball on a racket. An approximation to the optimal solution of the task is derived by means of optimization theory. In order to model the learning process, the problem is coded for a genetic algorithm in representations without sensory or with sensory information. For all representations the genetic algorithm is able to find passive control strategies, but learning speed and the quality of the outcome are significantly different. A comparison with data from human subjects shows that humans seem to apply yet different movement strategies to the ones proposed. For the feedback representation some implications arise for learning from demonstration.

am

link (url) [BibTex]

link (url) [BibTex]


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A genetic algorithm for evolution from an ecological perspective

Sternad, D., Schaal, S.

In 1992 Lectures in Complex Systems, pages: 223-231, (Editors: Nadel, L.;Stein, D.), Addison-Wesley, Redwood City, CA, 1993, clmc (inbook)

Abstract
In the population model presented, an evolutionary dynamic is explored which is based on the operator characteristics of genetic algorithms. An essential modification in the genetic algorithms is the inclusion of a constraint in the mixing of the gene pool. The pairing for the crossover is governed by a selection principle based on a complementarity criterion derived from the theoretical tenet of perception-action (P-A) mutuality of ecological psychology. According to Swenson and Turvey [37] P-A mutuality underlies evolution and is an integral part of its thermodynamics. The present simulation tested the contribution of P-A-cycles in evolutionary dynamics. A numerical experiment compares the population's evolution with and without this intentional component. The effect is measured in the difference of the rate of energy dissipation, as well as in three operationalized aspects of complexity. The results support the predicted increase in the rate of energy dissipation, paralleled by an increase in the average heterogeneity of the population. Furthermore, the spatio-temporal evolution of the system is tested for the characteristic power-law relations of a nonlinear system poised in a critical state. The frequency distribution of consecutive increases in population size shows a significantly different exponent in functional relationship.

am

[BibTex]

[BibTex]