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2017


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Editorial for the Special Issue on Microdevices and Microsystems for Cell Manipulation

Hu, W., Ohta, A. T.

8, Multidisciplinary Digital Publishing Institute, September 2017 (misc)

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DOI [BibTex]

2017


DOI [BibTex]


Parameterized Model of {2D} Articulated Human Shape
Parameterized Model of 2D Articulated Human Shape

Black, M. J., Freifeld, O., Weiss, A., Loper, M., Guan, P.

September 2017, U.S.~Patent 9,761,060 (misc)

Abstract
Disclosed are computer-readable devices, systems and methods for generating a model of a clothed body. The method includes generating a model of an unclothed human body, the model capturing a shape or a pose of the unclothed human body, determining two-dimensional contours associated with the model, and computing deformations by aligning a contour of a clothed human body with a contour of the unclothed human body. Based on the two-dimensional contours and the deformations, the method includes generating a first two-dimensional model of the unclothed human body, the first two-dimensional model factoring the deformations of the unclothed human body into one or more of a shape variation component, a viewpoint change, and a pose variation and learning an eigen-clothing model using principal component analysis applied to the deformations, wherein the eigen-clothing model classifies different types of clothing, to yield a second two-dimensional model of a clothed human body.

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Google Patents [BibTex]


Physical and Behavioral Factors Improve Robot Hug Quality
Physical and Behavioral Factors Improve Robot Hug Quality

Block, A. E., Kuchenbecker, K. J.

Workshop Paper (2 pages) presented at the RO-MAN Workshop on Social Interaction and Multimodal Expression for Socially Intelligent Robots, Lisbon, Portugal, August 2017 (misc)

Abstract
A hug is one of the most basic ways humans can express affection. As hugs are so common, a natural progression of robot development is to have robots one day hug humans as seamlessly as these intimate human-human interactions occur. This project’s purpose is to evaluate human responses to different robot physical characteristics and hugging behaviors. Specifically, we aim to test the hypothesis that a warm, soft, touch-sensitive PR2 humanoid robot can provide humans with satisfying hugs by matching both their hugging pressure and their hugging duration. Thirty participants experienced and evaluated twelve hugs with the robot, divided into three randomly ordered trials that focused on physical robot char- acteristics and nine randomly ordered trials with varied hug pressure and duration. We found that people prefer soft, warm hugs over hard, cold hugs. Furthermore, users prefer hugs that physically squeeze them and release immediately when they are ready for the hug to end.

hi

Project Page [BibTex]

Project Page [BibTex]


Crowdshaping Realistic {3D} Avatars with Words
Crowdshaping Realistic 3D Avatars with Words

Streuber, S., Ramirez, M. Q., Black, M., Zuffi, S., O’Toole, A., Hill, M. Q., Hahn, C. A.

August 2017, Application PCT/EP2017/051954 (misc)

Abstract
A method for generating a body shape, comprising the steps: - receiving one or more linguistic descriptors related to the body shape; - retrieving an association between the one or more linguistic descriptors and a body shape; and - generating the body shape, based on the association.

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Google Patents [BibTex]

Google Patents [BibTex]


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Physically Interactive Exercise Games with a Baxter Robot

Fitter, N. T., Kuchenbecker, K. J.

Hands-on demonstration presented at the IEEE World Haptics Conference (WHC), Munich, Germany, June 2017 (misc)

hi

Project Page [BibTex]

Project Page [BibTex]


System and method for simulating realistic clothing
System and method for simulating realistic clothing

Black, M. J., Guan, P.

June 2017, U.S.~Patent 9,679,409 B2 (misc)

Abstract
Systems, methods, and computer-readable storage media for simulating realistic clothing. The system generates a clothing deformation model for a clothing type, wherein the clothing deformation model factors a change of clothing shape due to rigid limb rotation, pose-independent body shape, and pose-dependent deformations. Next, the system generates a custom-shaped garment for a given body by mapping, via the clothing deformation model, body shape parameters to clothing shape parameters. The system then automatically dresses the given body with the custom- shaped garment.

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Google Patents pdf [BibTex]


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Proton Pack: Visuo-Haptic Surface Data Recording

Burka, A., Kuchenbecker, K. J.

Hands-on demonstration presented at the IEEE World Haptics Conference (WHC), Munich, Germany, June 2017 (misc)

hi

Project Page [BibTex]

Project Page [BibTex]


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Teaching a Robot to Collaborate with a Human Via Haptic Teleoperation

Hu, S., Kuchenbecker, K. J.

Work-in-progress paper (2 pages) presented at the IEEE World Haptics Conference (WHC), Munich, Germany, June 2017 (misc)

hi

Project Page [BibTex]

Project Page [BibTex]


How Should Robots Hug?
How Should Robots Hug?

Block, A. E., Kuchenbecker, K. J.

Work-in-progress paper (2 pages) presented at the IEEE World Haptics Conference (WHC), Munich, Germany, June 2017 (misc)

hi

Project Page [BibTex]

Project Page [BibTex]


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An Interactive Augmented-Reality Video Training Platform for the da Vinci Surgical System

Carlson, J., Kuchenbecker, K. J.

Workshop paper (3 pages) presented at the ICRA Workshop on C4 Surgical Robots, Singapore, May 2017 (misc)

Abstract
Teleoperated surgical robots such as the Intuitive da Vinci Surgical System facilitate minimally invasive surgeries, which decrease risk to patients. However, these systems can be difficult to learn, and existing training curricula on surgical simulators do not offer students the realistic experience of a full operation. This paper presents an augmented-reality video training platform for the da Vinci that will allow trainees to rehearse any surgery recorded by an expert. While the trainee operates a da Vinci in free space, they see their own instruments overlaid on the expert video. Tools are identified in the source videos via color segmentation and kernelized correlation filter tracking, and their depth is calculated from the da Vinci’s stereoscopic video feed. The user tries to follow the expert’s movements, and if any of their tools venture too far away, the system provides instantaneous visual feedback and pauses to allow the user to correct their motion. The trainee can also rewind the expert video by bringing either da Vinci tool very close to the camera. This combined and augmented video provides the user with an immersive and interactive training experience.

hi

[BibTex]

[BibTex]


Chapter 8 - Micro- and nanorobots in Newtonian and biological viscoelastic fluids
Chapter 8 - Micro- and nanorobots in Newtonian and biological viscoelastic fluids

Palagi, S., (Walker) Schamel, D., Qiu, T., Fischer, P.

In Microbiorobotics, pages: 133 - 162, 8, Micro and Nano Technologies, Second edition, Elsevier, Boston, March 2017 (incollection)

Abstract
Swimming microorganisms are a source of inspiration for small scale robots that are intended to operate in fluidic environments including complex biomedical fluids. Nature has devised swimming strategies that are effective at small scales and at low Reynolds number. These include the rotary corkscrew motion that, for instance, propels a flagellated bacterial cell, as well as the asymmetric beat of appendages that sperm cells or ciliated protozoa use to move through fluids. These mechanisms can overcome the reciprocity that governs the hydrodynamics at small scale. The complex molecular structure of biologically important fluids presents an additional challenge for the effective propulsion of microrobots. In this chapter it is shown how physical and chemical approaches are essential in realizing engineered abiotic micro- and nanorobots that can move in biomedically important environments. Interestingly, we also describe a microswimmer that is effective in biological viscoelastic fluids that does not have a natural analogue.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Hand-Clapping Games with a Baxter Robot

Fitter, N. T., Kuchenbecker, K. J.

Hands-on demonstration presented at ACM/IEEE International Conference on Human-Robot Interaction (HRI), Vienna, Austria, March 2017 (misc)

Abstract
Robots that work alongside humans might be more effective if they could forge a strong social bond with their human partners. Hand-clapping games and other forms of rhythmic social-physical interaction may foster human-robot teamwork, but the design of such interactions has scarcely been explored. At the HRI 2017 conference, we will showcase several such interactions taken from our recent work with the Rethink Robotics Baxter Research Robot, including tempo-matching, Simon says, and Pat-a-cake-like games. We believe conference attendees will be both entertained and intrigued by this novel demonstration of social-physical HRI.

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Project Page [BibTex]

Project Page [BibTex]


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Automatic OSATS Rating of Trainee Skill at a Pediatric Laparoscopic Suturing Task

Oquendo, Y. A., Riddle, E. W., Hiller, D., Blinman, T. A., Kuchenbecker, K. J.

Surgical Endoscopy, 31(Supplement 1):S28, Extended abstract presented as a podium presentation at the Annual Meeting of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), Springer, Houston, USA, March 2017 (misc)

Abstract
Introduction: Minimally invasive surgery has revolutionized surgical practice, but challenges remain. Trainees must acquire complex technical skills while minimizing patient risk, and surgeons must maintain their skills for rare procedures. These challenges are magnified in pediatric surgery due to the smaller spaces, finer tissue, and relative dearth of both inanimate and virtual simulators. To build technical expertise, trainees need opportunities for deliberate practice with specific performance feedback, which is typically provided via tedious human grading. This study aimed to validate a novel motion-tracking system and machine learning algorithm for automatically evaluating trainee performance on a pediatric laparoscopic suturing task using a 1–5 OSATS Overall Skill rating. Methods: Subjects (n=14) ranging from medical students to fellows per- formed one or two trials of an intracorporeal suturing task in a custom pediatric laparoscopy training box (Fig. 1) after watching a video of ideal performance by an expert. The position and orientation of the tools and endoscope were recorded over time using Ascension trakSTAR magnetic motion-tracking sensors, and both instrument grasp angles were recorded over time using flex sensors on the handles. The 27 trials were video-recorded and scored on the OSATS scale by a senior fellow; ratings ranged from 1 to 4. The raw motion data from each trial was processed to calculate over 200 preliminary motion parameters. Regularized least-squares regression (LASSO) was used to identify the most predictive parameters for inclusion in a regression tree. Model performance was evaluated by leave-one-subject-out cross validation, wherein the automatic scores given to each subject’s trials (by a model trained on all other data) are compared to the corresponding human rater scores. Results: The best-performing LASSO algorithm identified 14 predictive parameters for inclusion in the regression tree, including completion time, linear path length, angular path length, angular acceleration, grasp velocity, and grasp acceleration. The final model’s raw output showed a strong positive correlation of 0.87 with the reviewer-generated scores, and rounding the output to the nearest integer yielded a leave-one-subject-out cross-validation accuracy of 77.8%. Results are summarized in the confusion matrix (Table 1). Conclusions: Our novel motion-tracking system and regression model automatically gave previously unseen trials overall skill scores that closely match scores from an expert human rater. With additional data and further development, this system may enable creation of a motion-based training platform for pediatric laparoscopic surgery and could yield insights into the fundamental components of surgical skill.

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[BibTex]

[BibTex]


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How Much Haptic Surface Data is Enough?

Burka, A., Kuchenbecker, K. J.

Workshop paper (5 pages) presented at the AAAI Spring Symposium on Interactive Multi-Sensory Object Perception for Embodied Agents, Stanford, USA, March 2017 (misc)

Abstract
The Proton Pack is a portable visuo-haptic surface interaction recording device that will be used to collect a vast multimodal dataset, intended for robots to use as part of an approach to understanding the world around them. In order to collect a useful dataset, we want to pick a suitable interaction duration for each surface, noting the tradeoff between data collection resources and completeness of data. One interesting approach frames the data collection process as an online learning problem, building an incremental surface model and using that model to decide when there is enough data. Here we examine how to do such online surface modeling and when to stop collecting data, using kinetic friction as a first domain in which to apply online modeling.

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link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


Appealing Avatars from {3D} Body Scans: Perceptual Effects of Stylization
Appealing Avatars from 3D Body Scans: Perceptual Effects of Stylization

Fleming, R., Mohler, B. J., Romero, J., Black, M. J., Breidt, M.

In Computer Vision, Imaging and Computer Graphics Theory and Applications: 11th International Joint Conference, VISIGRAPP 2016, Rome, Italy, February 27 – 29, 2016, Revised Selected Papers, pages: 175-196, Springer International Publishing, 2017 (inbook)

Abstract
Using styles derived from existing popular character designs, we present a novel automatic stylization technique for body shape and colour information based on a statistical 3D model of human bodies. We investigate whether such stylized body shapes result in increased perceived appeal with two different experiments: One focuses on body shape alone, the other investigates the additional role of surface colour and lighting. Our results consistently show that the most appealing avatar is a partially stylized one. Importantly, avatars with high stylization or no stylization at all were rated to have the least appeal. The inclusion of colour information and improvements to render quality had no significant effect on the overall perceived appeal of the avatars, and we observe that the body shape primarily drives the change in appeal ratings. For body scans with colour information, we found that a partially stylized avatar was perceived as most appealing.

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publisher site pdf DOI [BibTex]

publisher site pdf DOI [BibTex]


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Computing with Uncertainty

Hennig, P.

2017 (mpi_year_book)

Abstract
Machine learning requires computer hardware to reliable and efficiently compute estimations for ever more complex and fundamentally incomputable quantities. A research team at MPI for Intelligent Systems in Tübingen develops new algorithms which purposely lower the precision of computations and return an explicit measure of uncertainty over the correct result alongside the estimate. Doing so allows for more flexible management of resources, and increases the reliability of intelligent systems.

link (url) DOI [BibTex]


Enhancing Human-Computer Interaction via Electrovibration
Enhancing Human-Computer Interaction via Electrovibration

Emgin, S. E., Sadia, B., Vardar, Y., Basdogan, C.

Demo in IEEE World Haptics, 2017 (misc)

Abstract
We present a compact tablet that displays electrostatic haptic feedback to the user. We track user?s finger position via an infrared frame and then display haptic feedback through a capacitive touch screen based on her/his position. In order to demonstrate practical utility of the proposed system, the following applications have been developed: (1) Online Shopping application allows users to be able to feel the cord density of two different fabrics. (2) Education application asks user to add two numbers by dragging one number onto another in order to match the sum. After selecting the first number, haptic feedback assists user to select the right pair. (3) Gaming/Entertainment application presents users a bike riding experience on three different road textures -smooth, bumpy, and sandy. (4) User Interface application in which users are asked to drag two visually identical folders. While dragging, users are able to differentiate the amount of data in each folder based on haptic resistance.

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[BibTex]

[BibTex]


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Robot Learning

Peters, J., Lee, D., Kober, J., Nguyen-Tuong, D., Bagnell, J., Schaal, S.

In Springer Handbook of Robotics, pages: 357-394, 15, 2nd, (Editors: Siciliano, Bruno and Khatib, Oussama), Springer International Publishing, 2017 (inbook)

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Project Page [BibTex]

Project Page [BibTex]


Learning to Filter Object Detections
Learning to Filter Object Detections

Prokudin, S., Kappler, D., Nowozin, S., Gehler, P.

In Pattern Recognition: 39th German Conference, GCPR 2017, Basel, Switzerland, September 12–15, 2017, Proceedings, pages: 52-62, Springer International Publishing, Cham, 2017 (inbook)

Abstract
Most object detection systems consist of three stages. First, a set of individual hypotheses for object locations is generated using a proposal generating algorithm. Second, a classifier scores every generated hypothesis independently to obtain a multi-class prediction. Finally, all scored hypotheses are filtered via a non-differentiable and decoupled non-maximum suppression (NMS) post-processing step. In this paper, we propose a filtering network (FNet), a method which replaces NMS with a differentiable neural network that allows joint reasoning and re-scoring of the generated set of hypotheses per image. This formulation enables end-to-end training of the full object detection pipeline. First, we demonstrate that FNet, a feed-forward network architecture, is able to mimic NMS decisions, despite the sequential nature of NMS. We further analyze NMS failures and propose a loss formulation that is better aligned with the mean average precision (mAP) evaluation metric. We evaluate FNet on several standard detection datasets. Results surpass standard NMS on highly occluded settings of a synthetic overlapping MNIST dataset and show competitive behavior on PascalVOC2007 and KITTI detection benchmarks.

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Paper link (url) DOI Project Page [BibTex]

Paper link (url) DOI Project Page [BibTex]


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Biomechanics and Locomotion Control in Legged Animals and Legged Robots

Sproewitz, A., Heim, S.

2017 (mpi_year_book)

Abstract
An animal's running gait is dynamic, efficient, elegant, and adaptive. We see locomotion in animals as an orchestrated interplay of the locomotion apparatus, interacting with its environment. The Dynamic Locomotion Group at the Max Planck Institute for Intelligent Systems in Stuttgart develops novel legged robots to decipher aspects of biomechanics and neuromuscular control of legged locomotion in animals, and to understand general principles of locomotion.

link (url) DOI [BibTex]


Reproduction of textures based on electrovibration
Reproduction of textures based on electrovibration

Fiedler, T., Vardar, Y., Strese, M., Steinbach, E., Basdogan, C.

Demo in IEEE World Haptics, 2017 (misc)

Abstract
This demonstration presents an approach to represent textures based on electovibration. We collect acceleration data which occurs while sliding a tool tip over a real texture surface. The prerecorded data was collected by a ADXL335 accelerometer, which is mounted on a FALCON device moving on the x-axis with a regulated velocity. In order to replicate the same acceleration with electrovibration, we found two problems. The frequency of one sine wave shifts to the double frequency. This effect originates from the electrostatic force between the finger pad and the tactile display as proposed by Kactmarek et Al. [1]. Taking the square root of the input signal corrects the effect. This was also earlier proposed by [1, 2, 3] However, if not only one but multiple sine waves are displayed interference occur and acceleration signals from real textures may not feel perceptually realistic. We propose to display only the dominant frequencies from a real texture signal. Peak frequencies are determined within the respect of the JND of 11 percent found by earlier literature. A new sine wave signal with the dominant frequencies is created. In the demo, we will let the attendees feel the differences between prerecorded and artificially created textures.

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[BibTex]

[BibTex]


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Policy Gradient Methods

Peters, J., Bagnell, J.

In Encyclopedia of Machine Learning and Data Mining, pages: 982-985, 2nd, (Editors: Sammut, Claude and Webb, Geoffrey I.), Springer US, 2017 (inbook)

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link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Unsupervised clustering of EOG as a viable substitute for optical eye-tracking

Flad, N., Fomina, T., Bülthoff, H. H., Chuang, L. L.

In First Workshop on Eye Tracking and Visualization (ETVIS 2015), pages: 151-167, Mathematics and Visualization, (Editors: Burch, M., Chuang, L., Fisher, B., Schmidt, A., and Weiskopf, D.), Springer, 2017 (inbook)

ei

DOI [BibTex]

DOI [BibTex]


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Statistical Asymmetries Between Cause and Effect

Janzing, D.

In Time in Physics, pages: 129-139, Tutorials, Schools, and Workshops in the Mathematical Sciences, (Editors: Renner, Renato and Stupar, Sandra), Springer International Publishing, Cham, 2017 (inbook)

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Robot Learning

Peters, J., Tedrake, R., Roy, N., Morimoto, J.

In Encyclopedia of Machine Learning and Data Mining, pages: 1106-1109, 2nd, (Editors: Sammut, Claude and Webb, Geoffrey I.), Springer US, 2017 (inbook)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


Design of a visualization scheme for functional connectivity data of Human Brain
Design of a visualization scheme for functional connectivity data of Human Brain

Bramlage, L.

Hochschule Osnabrück - University of Applied Sciences, 2017 (thesis)

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Bramlage_BSc_2017.pdf [BibTex]


Decentralized Simultaneous Multi-target Exploration using a Connected Network of Multiple Robots
Decentralized Simultaneous Multi-target Exploration using a Connected Network of Multiple Robots

Nestmeyer, T., Robuffo Giordano, P., Bülthoff, H. H., Franchi, A.

In pages: 989-1011, Autonomous Robots, 2017 (incollection)

ps

[BibTex]

[BibTex]


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Momentum-Centered Control of Contact Interactions

Righetti, L., Herzog, A.

In Geometric and Numerical Foundations of Movements, 117, pages: 339-359, Springer Tracts in Advanced Robotics, Springer, Cham, 2017 (incollection)

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link (url) [BibTex]

link (url) [BibTex]

2011


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Projected Newton-type methods in machine learning

Schmidt, M., Kim, D., Sra, S.

In Optimization for Machine Learning, pages: 305-330, (Editors: Sra, S., Nowozin, S. and Wright, S. J.), MIT Press, Cambridge, MA, USA, December 2011 (inbook)

Abstract
We consider projected Newton-type methods for solving large-scale optimization problems arising in machine learning and related fields. We first introduce an algorithmic framework for projected Newton-type methods by reviewing a canonical projected (quasi-)Newton method. This method, while conceptually pleasing, has a high computation cost per iteration. Thus, we discuss two variants that are more scalable, namely, two-metric projection and inexact projection methods. Finally, we show how to apply the Newton-type framework to handle non-smooth objectives. Examples are provided throughout the chapter to illustrate machine learning applications of our framework.

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PDF Web [BibTex]

2011


PDF Web [BibTex]


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Combined whole-body PET/MR imaging: MR contrast agents do not affect the quantitative accuracy of PET following attenuation correction

Lois, C., Kupferschläger, J., Bezrukov, I., Schmidt, H., Werner, M., Mannheim, J., Pichler, B., Schwenzer, N., Beyer, T.

(SST15-05 ), 97th Scientific Assemble and Annual Meeting of the Radiological Society of North America (RSNA), December 2011 (talk)

Abstract
PURPOSE Combined PET/MR imaging entails the use of MR contrast agents (MRCA) as part of integrated protocols. We assess additional attenuation of the PET emission signals in the presence of oral and intraveneous (iv) MRCA made up of iron oxide and Gd-chelates, respectively. METHOD AND MATERIALS Phantom scans were performed on a clinical PET/CT (Biograph HiRez16, Siemens) and integrated whole-body PET/MR (Biograph mMR, Siemens) using oral (Lumirem) and intraveneous (Gadovist) MRCA. Reference PET attenuation values were determined on a small-animal PET (Inveon, Siemens) using standard PET transmission imaging (TX). Seven syringes of 5mL were filled with (a) Water, (b) Lumirem_100 (100% conc.), (c) Gadovist_100 (100%), (d) Gadovist_18 (18%), (e) Gadovist_02 (0.2%), (f) Imeron-400 CT iv-contrast (100%) and (g) Imeron-400 (2.4%). The same set of syringes was scanned on CT (Sensation16, Siemens) at 120kVp and 160mAs. The effect of MRCA on the attenuation of PET emission data was evaluated using a 20cm cylinder filled uniformly with [18F]-FDG (FDG) in water (BGD). Three 4.5cm diameter cylinders were inserted into the phantom: (C1) Teflon, (C2) Water+FDG (2:1) and (C3) Lumirem_100+FDG (2:1). Two 50mL syringes filled with Gadovist_02+FDG (Sy1) and water+FDG (Sy2) were attached to the sides of (C1) to mimick the effects of iv-contrast in vessels near bone. Syringe-to-background activity ratio was 4-to-1. PET emission data were acquired for 10min each using the PET/CT and the PET/MR. Images were reconstructed using CT- and MR-based attenuation correction. RESULTS Mean linear PET attenuation (cm-1) on TX was (a) 0.098, (b) 0.098, (c) 0.300, (d) 0.134, (e) 0.095, (f) 0.397 and (g) 0.105. Corresponding CT attenuation (HU) was: (a) 5, (b) 14, (c) 3070, (d) 1040, (e) 13, (f) 3070 and (g) 347. Lumirem had little effect on PET attenuation with (C3) being 13% and 10% higher than (C2) on PET/CT and PET/MR, respectively. Gadovist_02 had even smaller effects with (Sy1) being 2.5% lower than (Sy2) on PET/CT and 1.2% higher than (Sy2) on PET/MR. CONCLUSION MRCA in high and clinically relevant concentrations have attenuation values similar to that of CT contrast and water, respectively. In clinical PET/MR scenarios MRCA are not expected to lead to significant attenuation of the PET emission signals.

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Web [BibTex]

Web [BibTex]


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Cooperative Cuts: a new use of submodularity in image segmentation

Jegelka, S.

Second I.S.T. Austria Symposium on Computer Vision and Machine Learning, October 2011 (talk)

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Web [BibTex]

Web [BibTex]


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Effect of MR Contrast Agents on Quantitative Accuracy of PET in Combined Whole-Body PET/MR Imaging

Lois, C., Bezrukov, I., Schmidt, H., Schwenzer, N., Werner, M., Pichler, B., Kupferschläger, J., Beyer, T.

2011(MIC3-3), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (talk)

Abstract
Combined whole-body PET/MR systems are being tested in clinical practice today. Integrated imaging protocols entail the use of MR contrast agents (MRCA) that could bias PET attenuation correction. In this work, we assess the effect of MRCA in PET/MR imaging. We analyze the effect of oral and intravenous MRCA on PET activity after attenuation correction. We conclude that in clinical scenarios, MRCA are not expected to lead to significant attenuation of PET signals, and that attenuation maps are not biased after the ingestion of adequate oral contrasts.

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Web [BibTex]

Web [BibTex]


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First Results on Patients and Phantoms of a Fully Integrated Clinical Whole-Body PET/MRI

Schmidt, H., Schwenzer, N., Bezrukov, I., Kolb, A., Mantlik, F., Kupferschläger, J., Lois, C., Sauter, A., Brendle, C., Pfannenberg, C., Pichler, B.

2011(J2-8), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (talk)

Abstract
First clinical fully integrated whole-body PET/MR scanners are just entering the field. Here, we present studies toward quantification accuracy and variation within the PET field of view of small lesions from our BrainPET/MRI, a dedicated clinical brain scanner which was installed three years ago in Tbingen. Also, we present first results for patient and phantom scans of a fully integral whole-body PET/MRI, which was installed two months ago at our department. The quantification accuracy and homogeneity of the BrainPET-Insert (Siemens Medical Solutions, Germany) installed inside the magnet bore of a clinical 3T MRI scanner (Magnetom TIM Trio, Siemens Medical Solutions, Germany) was evaluated by using eight hollow spheres with inner diameters from 3.95 to 7.86 mm placed at different positions inside a homogeneous cylinder phantom with an 9:1 and 6:1 sphere to background ratio. The quantification accuracy for small lesions at different positions in the PET FoV shows a standard deviation of up to 11% and is acceptable for quantitative brain studies where the homogeneity of quantification on the entire FoV is essental. Image quality and resolution of the new Siemens whole-body PET/MR system (Biograph mMR, Siemens Medical Solutions, Germany) was evaluated according to the NEMA NU2 2007 protocol using a body phantom containing six spheres with inner diameter from 10 to 37 mm at sphere to background ratios of 8:1 and 4:1 and the F-18 point sources located at different positions inside the PET FoV, respectively. The evaluation of the whole-body PET/MR system reveals a good PET image quality and resolution comparable to state-of-the-art clinical PET/CT scanners. First images of patient studies carried out at the whole-body PET/MR are presented highlighting the potency of combined PET/MR imaging.

ei

Web [BibTex]

Web [BibTex]


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Effect of MR contrast agents on quantitative accuracy of PET in combined whole-body PET/MR imaging

Lois, C., Kupferschläger, J., Bezrukov, I., Schmidt, H., Werner, M., Mannheim, J., Pichler, B., Schwenzer, N., Beyer, T.

(OP314), Annual Congress of the European Association of Nuclear Medicine (EANM), October 2011 (talk)

Abstract
PURPOSE:Combined PET/MR imaging entails the use of MR contrast agents (MRCA) as part of integrated protocols. MRCA are made up of iron oxide and Gd-chelates for oral and intravenous (iv) application, respectively. We assess additional attenuation of the PET emission signals in the presence of oral and iv MRCA.MATERIALS AND METHODS:Phantom scans were performed on a clinical PET/CT (Biograph HiRez16, Siemens) and an integrated whole-body PET/MR (Biograph mMR, Siemens). Two common MRCA were evaluated: Lumirem (oral) and Gadovist (iv).Reference PET attenuation values were determined on a dedicated small-animal PET (Inveon, Siemens) using equivalent standard PET transmission source imaging (TX). Seven syringes of 5mL were filled with (a) Water, (b) Lumirem_100 (100% concentration), (c) Gadovist_100 (100%), (d) Gadovist_18 (18%), (e) Gadovist_02 (0.2%), (f) Imeron-400 CT iv-contrast (100%) and (g) Imeron-400 (2.4%). The same set of syringes was scanned on CT (Sensation16, Siemens) at 120kVp and 160mAs.The effect of MRCA on the attenuation of PET emission data was evaluated using a 20cm cylinder filled uniformly with [18F]-FDG (FDG) in water (BGD). Three 4.5cm diameter cylinders were inserted into the phantom: (C1) Teflon, (C2) Water+FDG (2:1) and (C3) Lumirem_100+FDG (2:1). Two 50mL syringes filled with Gadovist_02+FDG (Sy1) and water+FDG (Sy2) were attached to the sides of (C1) to mimick the effects of iv-contrast in vessels near bone. Syringe-to-background activity ratio was 4-to-1.PET emission data were acquired for 10min each using the PET/CT and the PET/MR. Images were reconstructed using CT- and MR-based attenuation correction (AC). Since Teflon is not correctly identified on MR, PET(/MR) data were reconstructed using MR-AC and CT-AC.RESULTS:Mean linear PET attenuation (cm-1) on TX was (a) 0.098, (b) 0.098, (c) 0.300, (d) 0.134, (e) 0.095, (f) 0.397 and (g) 0.105. Corresponding CT attenuation (HU) was: (a) 5, (b) 14, (c) 3070, (d) 1040, (e) 13, (f) 3070 and (g) 347.Lumirem had little effect on PET attenuation with (C3) being 13%, 10% and 11% higher than (C2) on PET/CT, PET/MR with MR-AC, and PET/MR with CT-AC, respectively. Gadovist_02 had even smaller effects with (Sy1) being 2.5% lower, 1.2% higher, and 3.5% lower than (Sy2) on PET/CT, PET/MR with MR-AC and PET/MR with CT-AC, respectively.CONCLUSION:MRCA in high and clinically relevant concentrations have attenuation values similar to that of CT contrast and water, respectively. In clinical PET/MR scenarios MRCA are not expected to lead to significant attenuation of the PET emission signals.

ei

Web [BibTex]

Web [BibTex]


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Multi-parametric Tumor Characterization and Therapy Monitoring using Simultaneous PET/MRI: initial results for Lung Cancer and GvHD

Sauter, A., Schmidt, H., Gueckel, B., Brendle, C., Bezrukov, I., Mantlik, F., Kolb, A., Mueller, M., Reimold, M., Federmann, B., Hetzel, J., Claussen, C., Pfannenberg, C., Horger, M., Pichler, B., Schwenzer, N.

(T110), 2011 World Molecular Imaging Congress (WMIC), September 2011 (talk)

Abstract
Hybrid imaging modalities such as [18F]FDG-PET/CT are superior in staging of e.g. lung cancer disease compared with stand-alone modalities. Clinical PET/MRI systems are about to enter the field of hybrid imaging and offer potential advantages. One added value could be a deeper insight into the tumor metabolism and tumorigenesis due to the combination of PET and dedicated MR methods such as MRS and DWI. Additionally, therapy monitoring of diffucult to diagnose disease such as chronic sclerodermic GvHD (csGvHD) can potentially be improved by this combination. We have applied PET/MRI in 3 patients with lung cancer and 4 patients with csGvHD before and during therapy. All 3 patients had lung cancer confirmed by histology (2 adenocarcinoma, 1 carcinoid). First, a [18F]FDG-PET/CT was performed with the following parameters: injected dose 351.7±25.1 MBq, uptake time 59.0±2.6 min, 3 min/bed. Subsequently, patients were brought to the PET/MRI imaging facility. The whole-body PET/MRI Biograph mMR system comprises 56 detector cassettes with a 59.4 cm transaxial and 25.8 cm axial FoV. The MRI is a modified Verio system with a magnet bore of 60 cm. The following parameters for PET acquisition were applied: uptake time 121.3±2.3 min, 3 bed positions, 6 min/bed. T1w, T2w, and DWI MR images were recorded simultaneously for each bed. Acquired PET data were reconstructed with an iterative 3D OSEM algorithm using 3 iterations and 21 subsets, Gaussian filter of 3 mm. The 4 patients with GvHD were brought to the brainPET/MRI imaging facility 2:10h-2:28h after tracer injection. A 9 min brainPET-acquisition with simultaneous MRI of the lower extremities was accomplished. MRI examination included T1-weighted (pre and post gadolinium) and T2-weighted sequences. Attenuation correction was calculated based on manual bone segmentation and thresholds for soft tissue, fat and air. Soleus muscle (m), crural fascia (f1) and posterior crural intermuscular septum fascia (f2) were surrounded with ROIs based on the pre-treatment T1-weighted images and coregistered using IRW (Siemens). Fascia-to-muscle ratios for PET (f/m), T1 contrast uptake (T1_post-contrast_f-pre-contrast_f/post-contrast_m-pre-contrast_m) and T2 (T2_f/m) were calculated. Both patients with adenocarcinoma show a lower ADC value compared with the carcinoid patient suggesting a higher cellularity. This is also reflected in FDG-PET with higher SUV values. Our initial results reveal that PET/MRI can provide complementary information for a profound tumor characterization and therapy monitoring. The high soft tissue contrast provided by MRI is valuable for the assessment of the fascial inflammation. While in the first patient FDG and contrast uptake as well as edema, represented by T2 signals, decreased with ongoing therapy, all parameters remained comparatively stable in the second patient. Contrary to expectations, an increase in FDG uptake of patient 3 and 4 was accompanied by an increase of the T2 signals, but a decrease in contrast uptake. These initial results suggest that PET/MRI provides complementary information of the complex disease mechanisms in fibrosing disorders.

ei

Web [BibTex]

Web [BibTex]


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Please \soutdo not touch the robot

Romano, J. M., Kuchenbecker, K. J.

Hands-on demonstration presented at IEEE/RSJ Conference on Intelligent Robots and Systems (IROS), San Francisco, California, sep 2011 (misc)

hi

[BibTex]

[BibTex]


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Statistical Image Analysis and Percolation Theory

Langovoy, M., Habeck, M., Schölkopf, B.

2011 Joint Statistical Meetings (JSM), August 2011 (talk)

Abstract
We develop a novel method for detection of signals and reconstruction of images in the presence of random noise. The method uses results from percolation theory. We specifically address the problem of detection of multiple objects of unknown shapes in the case of nonparametric noise. The noise density is unknown and can be heavy-tailed. The objects of interest have unknown varying intensities. No boundary shape constraints are imposed on the objects, only a set of weak bulk conditions is required. We view the object detection problem as hypothesis testing for discrete statistical inverse problems. We present an algorithm that allows to detect greyscale objects of various shapes in noisy images. We prove results on consistency and algorithmic complexity of our procedures. Applications to cryo-electron microscopy are presented.

ei

Web [BibTex]

Web [BibTex]


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Body-Grounded Tactile Actuators for Playback of Human Physical Contact

Stanley, A. A., Kuchenbecker, K. J.

Hands-on demonstration presented at IEEE World Haptics Conference, Istanbul, Turkey, June 2011 (misc)

hi

[BibTex]

[BibTex]


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Statistical Learning Theory: Models, Concepts, and Results

von Luxburg, U., Schölkopf, B.

In Handbook of the History of Logic, Vol. 10: Inductive Logic, 10, pages: 651-706, (Editors: Gabbay, D. M., Hartmann, S. and Woods, J. H.), Elsevier North Holland, Amsterdam, Netherlands, May 2011 (inbook)

Abstract
Statistical learning theory provides the theoretical basis for many of today's machine learning algorithms and is arguably one of the most beautifully developed branches of artificial intelligence in general. It originated in Russia in the 1960s and gained wide popularity in the 1990s following the development of the so-called Support Vector Machine (SVM), which has become a standard tool for pattern recognition in a variety of domains ranging from computer vision to computational biology. Providing the basis of new learning algorithms, however, was not the only motivation for developing statistical learning theory. It was just as much a philosophical one, attempting to answer the question of what it is that allows us to draw valid conclusions from empirical data. In this article we attempt to give a gentle, non-technical overview over the key ideas and insights of statistical learning theory. We do not assume that the reader has a deep background in mathematics, statistics, or computer science. Given the nature of the subject matter, however, some familiarity with mathematical concepts and notations and some intuitive understanding of basic probability is required. There exist many excellent references to more technical surveys of the mathematics of statistical learning theory: the monographs by one of the founders of statistical learning theory ([Vapnik, 1995], [Vapnik, 1998]), a brief overview over statistical learning theory in Section 5 of [Sch{\"o}lkopf and Smola, 2002], more technical overview papers such as [Bousquet et al., 2003], [Mendelson, 2003], [Boucheron et al., 2005], [Herbrich and Williamson, 2002], and the monograph [Devroye et al., 1996].

ei

PDF Web DOI [BibTex]

PDF Web DOI [BibTex]


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Cooperative Cuts

Jegelka, S.

COSA Workshop: Combinatorial Optimization, Statistics, and Applications, March 2011 (talk)

Abstract
Combinatorial problems with submodular cost functions have recently drawn interest. In a standard combinatorial problem, the sum-of-weights cost is replaced by a submodular set function. The result is a powerful model that is though very hard. In this talk, I will introduce cooperative cuts, minimum cuts with submodular edge weights. I will outline methods to approximately solve this problem, and show an application in computer vision. If time permits, the talk will also sketch regret-minimizing online algorithms for submodular-cost combinatorial problems. This is joint work with Jeff Bilmes (University of Washington).

ei

Web [BibTex]

Web [BibTex]


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Robot Learning

Peters, J., Tedrake, R., Roy, N., Morimoto, J.

In Encyclopedia of Machine Learning, pages: 865-869, Encyclopedia of machine learning, (Editors: Sammut, C. and Webb, G. I.), Springer, New York, NY, USA, January 2011 (inbook)

ei

PDF Web DOI [BibTex]

PDF Web DOI [BibTex]


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What You Expect Is What You Get? Potential Use of Contingent Negative Variation for Passive BCI Systems in Gaze-Based HCI

Ihme, K., Zander, TO.

In Affective Computing and Intelligent Interaction, 6975, pages: 447-456, Lecture Notes in Computer Science, (Editors: D’Mello, S., Graesser, A., Schuller, B. and Martin, J.-C.), Springer, Berlin, Germany, 2011 (inbook)

Abstract
When using eye movements for cursor control in human-computer interaction (HCI), it may be difficult to find an appropriate substitute for the click operation. Most approaches make use of dwell times. However, in this context the so-called Midas-Touch-Problem occurs which means that the system wrongly interprets fixations due to long processing times or spontaneous dwellings of the user as command. Lately it has been shown that brain-computer interface (BCI) input bears good prospects to overcome this problem using imagined hand movements to elicit a selection. The current approach tries to develop this idea further by exploring potential signals for the use in a passive BCI, which would have the advantage that the brain signals used as input are generated automatically without conscious effort of the user. To explore event-related potentials (ERPs) giving information about the user’s intention to select an object, 32-channel electroencephalography (EEG) was recorded from ten participants interacting with a dwell-time-based system. Comparing ERP signals during the dwell time with those occurring during fixations on a neutral cross hair, a sustained negative slow cortical potential at central electrode sites was revealed. This negativity might be a contingent negative variation (CNV) reflecting the participants’ anticipation of the upcoming selection. Offline classification suggests that the CNV is detectable in single trial (mean accuracy 74.9 %). In future, research on the CNV should be accomplished to ensure its stable occurence in human-computer interaction and render possible its use as a potential substitue for the click operation.

ei

DOI [BibTex]

DOI [BibTex]


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Kernel Methods in Bioinformatics

Borgwardt, KM.

In Handbook of Statistical Bioinformatics, pages: 317-334, Springer Handbooks of Computational Statistics ; 3, (Editors: Lu, H.H.-S., Schölkopf, B. and Zhao, H.), Springer, Berlin, Germany, 2011 (inbook)

Abstract
Kernel methods have now witnessed more than a decade of increasing popularity in the bioinformatics community. In this article, we will compactly review this development, examining the areas in which kernel methods have contributed to computational biology and describing the reasons for their success.

ei

PDF DOI [BibTex]

PDF DOI [BibTex]


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Cue Combination: Beyond Optimality

Rosas, P., Wichmann, F.

In Sensory Cue Integration, pages: 144-152, (Editors: Trommershäuser, J., Körding, K. and Landy, M. S.), Oxford University Press, 2011 (inbook)

ei

[BibTex]

[BibTex]


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Preparation of high-efficiency nanostructures of crystalline silicon at low temperatures, as catalyzed by metals: The decisive role of interface thermodynamics

Wang, Zumin, Jeurgens, Lars P. H., Mittemeijer, Eric J.

2011 (mpi_year_book)

Abstract
Metals may help to convert semiconductors from a disordered (amorphous) to an ordered (crystalline) form at low temperatures. A general, quantitative model description has been developed on the basis of interface thermodynamics, which provides fundamental understanding of such so-called metal-induced crystallization (MIC) of amorphous semiconductors. This fundamental understanding can allow the low-temperature (< 200 ºC) manufacturing of high-efficiency solar cells and crystalline-Si-based nanostructures on cheap and flexible substrates such as glasses, plastics and possibly even papers.

link (url) [BibTex]


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The sweet coat of living cells – from supramolecular organization and dynamics to biological function

Richter, Ralf

2011 (mpi_year_book)

Abstract
Many biological cells endow themselves with a sugar-rich coat that plays a key role in the protection of the cell and in structuring and communicating with its environment. An outstanding property of these pericellular coats is their dynamic self-organization into strongly hydrated and gel-like meshworks. Tailor-made model systems that are constructed from the molecular building blocks of pericellular coats can help to understand how the coats function.

link (url) [BibTex]


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Automated Control of AFM Based Nanomanipulation

Xie, H., Onal, C., Régnier, S., Sitti, M.

In Atomic Force Microscopy Based Nanorobotics, pages: 237-311, Springer Berlin Heidelberg, 2011 (incollection)

pi

[BibTex]

[BibTex]