Publications | Max Planck Institute for Intelligent Systems

47 results (View BibTeX file of all listed publications)

2015

Diversity of sharp wave-ripples in the CA1 of the macaque hippocampus and their brain wide signatures

Ramirez-Villegas, J. F., Logothetis, N. K., Besserve, M.

45th Annual Meeting of the Society for Neuroscience (Neuroscience 2015), October 2015 (poster)

2015

ei Ramirez-Villegas, J. F., Logothetis, N. K., Besserve, M. Diversity of sharp wave-ripples in the CA1 of the macaque hippocampus and their brain wide signatures 45th Annual Meeting of the Society for Neuroscience (Neuroscience 2015), October 2015 (poster)

link (url) [BibTex]

Retrospective rigid motion correction of undersampled MRI data

Loktyushin, A., Babayeva, M., Gallichan, D., Krueger, G., Scheffler, K., Kober, T.

23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine, ISMRM, June 2015 (poster)

[BibTex]

ei Loktyushin, A., Babayeva, M., Gallichan, D., Krueger, G., Scheffler, K., Kober, T. Retrospective rigid motion correction of undersampled MRI data 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine, ISMRM, June 2015 (poster)

[BibTex]

Improving Quantitative Susceptibility and R2* Mapping by Applying Retrospective Motion Correction

Feng, X., Loktyushin, A., Deistung, A., Reichenbach, J. R.

23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine, ISMRM, June 2015 (poster)

[BibTex]

ei Feng, X., Loktyushin, A., Deistung, A., Reichenbach, J. R. Improving Quantitative Susceptibility and R2* Mapping by Applying Retrospective Motion Correction 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine, ISMRM, June 2015 (poster)

[BibTex]

Increasing the sensitivity of Kepler to Earth-like exoplanets

Foreman-Mackey, D., Hogg, D., Schölkopf, B., Wang, D.

Workshop: 225th American Astronomical Society Meeting 2015 , pages: 105.01D, 2015 (poster)

Web link (url) [BibTex]

ei Foreman-Mackey, D., Hogg, D., Schölkopf, B., Wang, D. Increasing the sensitivity of Kepler to Earth-like exoplanets Workshop: 225th American Astronomical Society Meeting 2015 , pages: 105.01D, 2015 (poster)

Web link (url) [BibTex]

Calibrating the pixel-level Kepler imaging data with a causal data-driven model

Wang, D., Foreman-Mackey, D., Hogg, D., Schölkopf, B.

Workshop: 225th American Astronomical Society Meeting 2015 , pages: 258.08, 2015 (poster)

Web link (url) [BibTex]

ei Wang, D., Foreman-Mackey, D., Hogg, D., Schölkopf, B. Calibrating the pixel-level Kepler imaging data with a causal data-driven model Workshop: 225th American Astronomical Society Meeting 2015 , pages: 258.08, 2015 (poster)

Web link (url) [BibTex]

Learning robots

Trimpe, S.

2015 (mpi_year_book)

Abstract

An exploded power plant, collapsed buildings after an earthquake, a burning vehicle loaded with hazardous goods – all of these are dangerous situations for human emergency responders. What if we could send robots instead of humans? Researchers at the Autonomous Motion Department work on fundamental principles required to build intelligent robots which one day can help us in dangerous situations. A key requirement for making this happen is that robots must be enabled to learn.

link (url) [BibTex]

Trimpe, S. Learning robots 2015 (mpi_year_book)

link (url) [BibTex]

Disparity estimation from a generative light field model

Köhler, R., Schölkopf, B., Hirsch, M.

IEEE International Conference on Computer Vision (ICCV 2015), Workshop on Inverse Rendering, 2015, Note: This work has been presented as a poster and is not included in the workshop proceedings. (poster)

[BibTex]

ei Köhler, R., Schölkopf, B., Hirsch, M. Disparity estimation from a generative light field model IEEE International Conference on Computer Vision (ICCV 2015), Workshop on Inverse Rendering, 2015, Note: This work has been presented as a poster and is not included in the workshop proceedings. (poster)

[BibTex]

The smallest human-made nano-motor

Sánchez, Samuel

2015 (mpi_year_book)

Abstract

Tiny self-propelled motors which speed through the water and clean up pollutions along the way or small robots which can swim effortlessly through blood to one day transport medication to a certain part of the body – this sounds like taken from a science fiction movie script. However, Samuel Sánchez is already hard at work in his lab at the Max Planck Institute for Intelligent Systems in Stuttgart to make these visions come true. Self-propelled micro-nanorobots and the usage as integrated sensors in microfluid-chips: that’s the topic of Sánchez` research group.

link (url) [BibTex]

Sánchez, Samuel The smallest human-made nano-motor 2015 (mpi_year_book)

link (url) [BibTex]

2014

Dynamical source analysis of hippocampal sharp-wave ripple episodes

Ramirez-Villegas, J. F., Logothetis, N. K., Besserve, M.

Bernstein Conference, 2014 (poster)

DOI [BibTex]

2014

ei Ramirez-Villegas, J. F., Logothetis, N. K., Besserve, M. Dynamical source analysis of hippocampal sharp-wave ripple episodes Bernstein Conference, 2014 (poster)

DOI [BibTex]

FID-guided retrospective motion correction based on autofocusing

Babayeva, M., Loktyushin, A., Kober, T., Granziera, C., Nickisch, H., Gruetter, R., Krueger, G.

Joint Annual Meeting ISMRM-ESMRMB, Milano, Italy, 2014 (poster)

[BibTex]

ei Babayeva, M., Loktyushin, A., Kober, T., Granziera, C., Nickisch, H., Gruetter, R., Krueger, G. FID-guided retrospective motion correction based on autofocusing Joint Annual Meeting ISMRM-ESMRMB, Milano, Italy, 2014 (poster)

[BibTex]

Cluster analysis of sharp-wave ripple field potential signatures in the macaque hippocampus

Ramirez-Villegas, J. F., Logothetis, N. K., Besserve, M.

Computational and Systems Neuroscience Meeting (COSYNE), 2014 (poster)

[BibTex]

ei Ramirez-Villegas, J. F., Logothetis, N. K., Besserve, M. Cluster analysis of sharp-wave ripple field potential signatures in the macaque hippocampus Computational and Systems Neuroscience Meeting (COSYNE), 2014 (poster)

[BibTex]

Exploring complex diseases with intelligent systems

Borgwardt, K.

2014 (mpi_year_book)

Abstract

Physicians are collecting an ever increasing amount of data describing the health state of their patients. Is new knowledge about diseases hidden in this data, which could lead to better therapies? The field of Machine Learning in Biomedicine is concerned with the development of approaches which help to gain such insights from massive biomedical data.

link (url) [BibTex]

Borgwardt, K. Exploring complex diseases with intelligent systems 2014 (mpi_year_book)

link (url) [BibTex]

The cellular life-death decision – how mitochondrial membrane proteins can determine cell fate

García-Sáez, Ana J.

2014 (mpi_year_book)

Abstract

Living organisms have a very effective method for eliminating cells that are no longer needed: programmed death. Researchers in the group of Ana García Sáez work with a protein called Bax, a key regulator of apoptosis that creates pores with a flexible diameter inside the outer mitochondrial membrane. This step inevitably triggers the final death of the cell. These insights into the role of important key enzymes in setting off apoptosis could provide useful for developing drugs that can directly influence apoptosis.

link (url) [BibTex]

García-Sáez, Ana J. The cellular life-death decision – how mitochondrial membrane proteins can determine cell fate 2014 (mpi_year_book)

link (url) [BibTex]

2013

Coupling between spiking activity and beta band spatio-temporal patterns in the macaque PFC

Safavi, S., Panagiotaropoulos, T., Kapoor, V., Logothetis, N., Besserve, M.

43rd Annual Meeting of the Society for Neuroscience (Neuroscience), 2013 (poster)

[BibTex]

2013

ei Safavi, S., Panagiotaropoulos, T., Kapoor, V., Logothetis, N., Besserve, M. Coupling between spiking activity and beta band spatio-temporal patterns in the macaque PFC 43rd Annual Meeting of the Society for Neuroscience (Neuroscience), 2013 (poster)

[BibTex]

Gaussian Process Vine Copulas for Multivariate Dependence

Lopez-Paz, D., Hernandez-Lobato, J., Ghahramani, Z.

International Conference on Machine Learning (ICML), 2013 (poster)

PDF [BibTex]

ei Lopez-Paz, D., Hernandez-Lobato, J., Ghahramani, Z. Gaussian Process Vine Copulas for Multivariate Dependence International Conference on Machine Learning (ICML), 2013 (poster)

PDF [BibTex]

Domain Generalization via Invariant Feature Representation

Muandet, K., Balduzzi, D., Schölkopf, B.

30th International Conference on Machine Learning (ICML2013), 2013 (poster)

PDF [BibTex]

ei Muandet, K., Balduzzi, D., Schölkopf, B. Domain Generalization via Invariant Feature Representation 30th International Conference on Machine Learning (ICML2013), 2013 (poster)

PDF [BibTex]

Analyzing locking of spikes to spatio-temporal patterns in the macaque prefrontal cortex

Safavi, S., Panagiotaropoulos, T., Kapoor, V., Logothetis, N., Besserve, M.

Bernstein Conference, 2013 (poster)

DOI [BibTex]

ei Safavi, S., Panagiotaropoulos, T., Kapoor, V., Logothetis, N., Besserve, M. Analyzing locking of spikes to spatio-temporal patterns in the macaque prefrontal cortex Bernstein Conference, 2013 (poster)

DOI [BibTex]

One-class Support Measure Machines for Group Anomaly Detection

Muandet, K., Schölkopf, B.

29th Conference on Uncertainty in Artificial Intelligence (UAI), 2013 (poster)

PDF [BibTex]

ei Muandet, K., Schölkopf, B. One-class Support Measure Machines for Group Anomaly Detection 29th Conference on Uncertainty in Artificial Intelligence (UAI), 2013 (poster)

PDF [BibTex]

The Randomized Dependence Coefficient

Lopez-Paz, D., Hennig, P., Schölkopf, B.

Neural Information Processing Systems (NIPS), 2013 (poster)

ei pn

PDF [BibTex]

ei pn Lopez-Paz, D., Hennig, P., Schölkopf, B. The Randomized Dependence Coefficient Neural Information Processing Systems (NIPS), 2013 (poster)

PDF [BibTex]

Characterization of different types of sharp-wave ripple signatures in the CA1 of the macaque hippocampus

Ramirez-Villegas, J., Logothetis, N., Besserve, M.

4th German Neurophysiology PhD Meeting Networks, 2013 (poster)

Web [BibTex]

ei Ramirez-Villegas, J., Logothetis, N., Besserve, M. Characterization of different types of sharp-wave ripple signatures in the CA1 of the macaque hippocampus 4th German Neurophysiology PhD Meeting Networks, 2013 (poster)

Web [BibTex]

Perceiving Systems – Computers that see

Gehler, P. V.

2013 (mpi_year_book)

Abstract

Our research goal is to define in a mathematical precise way how visual perception works. We want to describe how intelligent systems understand images. To this end we study probabilistic models and statistical learning. Encoding prior knowledge about the world is complemented with automatic learning from training data. One aspect is being able to identify physical factors in images, such as lighting, geometry, and materials. Furthermore we want to automatically recognize and give names to objects and persons in images and understand the scene as a whole.

link (url) [BibTex]

Gehler, P. V. Perceiving Systems – Computers that see 2013 (mpi_year_book)

link (url) [BibTex]

Being small, being smart

Liu, Na

2013 (mpi_year_book)

Abstract

Metallic nanostructures feature plasmonic resonances which spatially confine light on the nanometer scale. In the ultimate limit of a single nanostructure, the electromagnetic field can be strongly concentrated in a volume of only a few hundred nm3 or less. We utilize such plasmonic focusing for hydrogen detection at the single particle level, which avoids any inhomogeneous broadening and statistical effects that would occur in sensors based on nanoparticle ensembles. This concept paves the road towards the observation of single catalytic processes in nanoreactors.

link (url) [BibTex]

Liu, Na Being small, being smart 2013 (mpi_year_book)

link (url) [BibTex]

2011

Spatiotemporal mapping of rhythmic activity in the inferior convexity of the macaque prefrontal cortex

Panagiotaropoulos, T., Besserve, M., Crocker, B., Kapoor, V., Tolias, A., Panzeri, S., Logothetis, N.

41(239.15), 41st Annual Meeting of the Society for Neuroscience (Neuroscience), November 2011 (poster)

Abstract

The inferior convexity of the macaque prefrontal cortex (icPFC) is known to be involved in higher order processing of sensory information mediating stimulus selection, attention and working memory. Until now, the vast majority of electrophysiological investigations of the icPFC employed single electrode recordings. As a result, relatively little is known about the spatiotemporal structure of neuronal activity in this cortical area. Here we study in detail the spatiotemporal properties of local field potentials (LFP's) in the icPFC using multi electrode recordings during anesthesia. We computed the LFP-LFP coherence as a function of frequency for thousands of pairs of simultaneously recorded sites anterior to the arcuate and inferior to the principal sulcus. We observed two distinct peaks of coherent oscillatory activity between approximately 4-10 and 15-25 Hz. We then quantified the instantaneous phase of these frequency bands using the Hilbert transform and found robust phase gradients across recording sites. The dependency of the phase on the spatial location reflects the existence of traveling waves of electrical activity in the icPFC. The dominant axis of these traveling waves roughly followed the ventral-dorsal plane. Preliminary results show that repeated visual stimulation with a 10s movie had no dramatic effect on the spatial structure of the traveling waves. Traveling waves of electrical activity in the icPFC could reflect highly organized cortical processing in this area of prefrontal cortex.

Web [BibTex]

2011

ei Panagiotaropoulos, T., Besserve, M., Crocker, B., Kapoor, V., Tolias, A., Panzeri, S., Logothetis, N. Spatiotemporal mapping of rhythmic activity in the inferior convexity of the macaque prefrontal cortex 41(239.15), 41st Annual Meeting of the Society for Neuroscience (Neuroscience), November 2011 (poster)

Web [BibTex]

Evaluation and Optimization of MR-Based Attenuation Correction Methods in Combined Brain PET/MR

Mantlik, F., Hofmann, M., Bezrukov, I., Schmidt, H., Kolb, A., Beyer, T., Reimold, M., Schölkopf, B., Pichler, B.

2011(MIC18.M-96), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (poster)

Abstract

Combined PET/MR provides simultaneous molecular and functional information in an anatomical context with unique soft tissue contrast. However, PET/MR does not support direct derivation of attenuation maps of objects and tissues within the measured PET field-of-view. Valid attenuation maps are required for quantitative PET imaging, specifically for scientific brain studies. Therefore, several methods have been proposed for MR-based attenuation correction (MR-AC). Last year, we performed an evaluation of different MR-AC methods, including simple MR thresholding, atlas- and machine learning-based MR-AC. CT-based AC served as gold standard reference. RoIs from 2 anatomic brain atlases with different levels of detail were used for evaluation of correction accuracy. We now extend our evaluation of different MR-AC methods by using an enlarged dataset of 23 patients from the integrated BrainPET/MR (Siemens Healthcare). Further, we analyze options for improving the MR-AC performance in terms of speed and accuracy. Finally, we assess the impact of ignoring BrainPET positioning aids during the course of MR-AC. This extended study confirms the overall prediction accuracy evaluation results of the first evaluation in a larger patient population. Removing datasets affected by metal artifacts from the Atlas-Patch database helped to improve prediction accuracy, although the size of the database was reduced by one half. Significant improvement in prediction speed can be gained at a cost of only slightly reduced accuracy, while further optimizations are still possible.

Web [BibTex]

ei Mantlik, F., Hofmann, M., Bezrukov, I., Schmidt, H., Kolb, A., Beyer, T., Reimold, M., Schölkopf, B., Pichler, B. Evaluation and Optimization of MR-Based Attenuation Correction Methods in Combined Brain PET/MR 2011(MIC18.M-96), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (poster)

Web [BibTex]

Atlas- and Pattern Recognition Based Attenuation Correction on Simultaneous Whole-Body PET/MR

Bezrukov, I., Schmidt, H., Mantlik, F., Schwenzer, N., Hofmann, M., Schölkopf, B., Pichler, B.

2011(MIC18.M-116), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (poster)

Abstract

With the recent availability of clinical whole-body PET/MRI it is possible to evaluate and further develop MR-based attenuation correction methods using simultaneously acquired PET/MR data. We present first results for MRAC on patient data acquired on a fully integrated whole-body PET/MRI (Biograph mMR, Siemens) using our method that applies atlas registration and pattern recognition (ATPR) and compare them to the segmentation-based (SEG) method provided by the manufacturer. The ATPR method makes use of a database of previously aligned pairs of MR-CT volumes to predict attenuation values on a continuous scale. The robustness of the method in presence of MR artifacts was improved by location and size based detection. Lesion to liver and lesion to blood ratios (LLR and LBR) were compared for both methods on 29 iso-contour ROIs in 4 patients. ATPR showed >20% higher LBR and LLR for ROIs in and >7% near osseous tissue. For ROIs in soft tissue, both methods yielded similar ratios with max. differences <6% . For ROIs located within metal artifacts in the MR image, ATPR showed >190% higher LLR and LBR than SEG, where ratios <0.1 occured. For lesions in the neighborhood of artifacts, both ratios were >15% higher for ATPR. If artifacts in MR volumes caused by metal implants are not accounted for in the computation of attenuation maps, they can lead to a strong decrease of lesion to background ratios, even to disappearance of hot spots. Metal implants are likely to occur in the patient collective receiving combined PET/MR scans, of our first 10 patients, 3 had metal implants. Our method is currently able to account for artifacts in the pelvis caused by prostheses. The ability of the ATPR method to account for bone leads to a significant increase of LLR and LBR in osseous tissue, which supports our previous evaluations with combined PET/CT and PET/MR data. For lesions within soft tissue, lesion to background ratios of ATPR and SEG were comparable.

Web [BibTex]

ei Bezrukov, I., Schmidt, H., Mantlik, F., Schwenzer, N., Hofmann, M., Schölkopf, B., Pichler, B. Atlas- and Pattern Recognition Based Attenuation Correction on Simultaneous Whole-Body PET/MR 2011(MIC18.M-116), 2011 IEEE Nuclear Science Symposium, Medical Imaging Conference (NSS-MIC), October 2011 (poster)

Web [BibTex]

Retrospective blind motion correction of MR images

Loktyushin, A., Nickisch, H., Pohmann, R.

Magnetic Resonance Materials in Physics, Biology and Medicine, 24(Supplement 1):498, 28th Annual Scientific Meeting ESMRMB, October 2011 (poster)

Abstract

We present a retrospective method, which significantly reduces ghosting and blurring artifacts due to subject motion. No modifications to the sequence (as in [2, 3]), or the use of additional equipment (as in [1]) are required. Our method iteratively searches for the transformation, that applied to the lines in k-space -- yields the sparsest Laplacian filter output in the spatial domain.

PDF Web DOI [BibTex]

ei Loktyushin, A., Nickisch, H., Pohmann, R. Retrospective blind motion correction of MR images Magnetic Resonance Materials in Physics, Biology and Medicine, 24(Supplement 1):498, 28th Annual Scientific Meeting ESMRMB, October 2011 (poster)

PDF Web DOI [BibTex]

Model based reconstruction for GRE EPI

Blecher, W., Pohmann, R., Schölkopf, B., Seeger, M.

Magnetic Resonance Materials in Physics, Biology and Medicine, 24(Supplement 1):493-494, 28th Annual Scientific Meeting ESMRMB, October 2011 (poster)

Abstract

Model based nonlinear image reconstruction methods for MRI [3] are at the heart of modern reconstruction techniques (e.g.compressed sensing [6]). In general, models are expressed as a matrix equation where y and u are column vectors of k-space and image data, X model matrix and e independent noise. However, solving the corresponding linear system is not tractable. Therefore fast nonlinear algorithms that minimize a function wrt.the unknown image are the method of choice: In this work a model for gradient echo EPI, is proposed that incorporates N/2 Ghost correction and correction for field inhomogeneities. In addition to reconstruction from full data, the model allows for sparse reconstruction, joint estimation of image, field-, and relaxation-map (like [5,8] for spiral imaging), and improved N/2 ghost correction.

PDF Web DOI [BibTex]

ei Blecher, W., Pohmann, R., Schölkopf, B., Seeger, M. Model based reconstruction for GRE EPI Magnetic Resonance Materials in Physics, Biology and Medicine, 24(Supplement 1):493-494, 28th Annual Scientific Meeting ESMRMB, October 2011 (poster)

PDF Web DOI [BibTex]

Simultaneous multimodal imaging of patients with bronchial carcinoma in a whole body MR/PET system

Brendle, C., Sauter, A., Schmidt, H., Schraml, C., Bezrukov, I., Martirosian, P., Hetzel, J., Müller, M., Claussen, C., Schwenzer, N., Pfannenberg, C.

Magnetic Resonance Materials in Physics, Biology and Medicine, 24(Supplement 1):141, 28th annual scientific meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRB), October 2011 (poster)

Abstract

Purpose/Introduction: Lung cancer is among the most frequent cancers (1). Exact determination of tumour extent and viability is crucial for adequate therapy guidance. [18F]-FDG-PET allows accurate staging and the evaluation of therapy response based on glucose metabolism. Diffusion weighted MRI (DWI) is another promising tool for the evaluation of tumour viability (2,3). The aim of the study was the simultaneous PET-MR acquisition in lung cancer patients and correlation of PET and MR data. Subjects and Methods: Seven patients (age 38-73 years, mean 61 years) with highly suspected or known bronchial carcinoma were examined. First, a [18F]-FDG-PET/CT was performed (injected dose: 332-380 MBq). Subsequently, patients were examined at the whole-body MR/PET (Siemens Biograph mMR). The MRI is a modified 3T Verio whole body system with a magnet bore of 60 cm (max. amplitude gradients 45 mT/m, max. slew rate 200 T/m/s). Concerning the PET, the whole-body MR/PET system comprises 56 detector cassettes with a 59.4 cm transaxial and 25.8 cm axial FoV. The following parameters for PET acquisition were applied: 2 bed positions, 6 min/bed with an average uptake time of 124 min after injection (range: 110-143 min). The attenuation correction of PET data was conducted with a segmentation-based method provided by the manufacturer. Acquired PET data were reconstructed with an iterative 3D OSEM algorithm using 3 iterations and 21 subsets, Gaussian filter of 3 mm. DWI MR images were recorded simultaneously for each bed using two b-values (0/800 s/mm2). SUVmax and ADCmin were assessed in a ROI analysis. The following ratios were calculated: SUVmax(tumor)/SUVmean(liver) and ADCmin(tumor)/ADCmean(muscle). Correlation between SUV and ADC was analyzed (Pearson’s correlation). Results: Diagnostic scans could be obtained in all patients with good tumour delineation. The spatial matching of PET and DWI data was very exact. Most tumours showed a pronounced FDG-uptake in combination with decreased ADC values. Significant correlation was found between SUV and ADC ratios (r = -0.87, p = 0.0118). Discussion/Conclusion: Simultaneous MR/PET imaging of lung cancer is feasible. The whole-body MR/PET system can provide complementary information regarding tumour viability and cellularity which could facilitate a more profound tumour characterization. Further studies have to be done to evaluate the importance of these parameters for therapy decisions and monitoring

Web DOI [BibTex]

ei Brendle, C., Sauter, A., Schmidt, H., Schraml, C., Bezrukov, I., Martirosian, P., Hetzel, J., Müller, M., Claussen, C., Schwenzer, N., Pfannenberg, C. Simultaneous multimodal imaging of patients with bronchial carcinoma in a whole body MR/PET system Magnetic Resonance Materials in Physics, Biology and Medicine, 24(Supplement 1):141, 28th annual scientific meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRB), October 2011 (poster)

Web DOI [BibTex]

Support Vector Machines for finding deletions and short insertions using paired-end short reads

Grimm, D., Hagmann, J., König, D., Weigel, D., Borgwardt, KM.

International Conference on Intelligent Systems for Molecular Biology (ISMB), 2011 (poster)

Web [BibTex]

ei Grimm, D., Hagmann, J., König, D., Weigel, D., Borgwardt, KM. Support Vector Machines for finding deletions and short insertions using paired-end short reads International Conference on Intelligent Systems for Molecular Biology (ISMB), 2011 (poster)

Web [BibTex]

Expectation Propagation for the Estimation of Conditional Bivariate Copulas

Hernandez-Lobato, J., Lopez-Paz, D., Gharhamani, Z.

2011 (poster)

PDF [BibTex]

ei Hernandez-Lobato, J., Lopez-Paz, D., Gharhamani, Z. Expectation Propagation for the Estimation of Conditional Bivariate Copulas 2011 (poster)

PDF [BibTex]

Statistical estimation for optimization problems on graphs

Langovoy, M., Sra, S.

Empirical Inference Symposium, 2011 (poster)

[BibTex]

ei Langovoy, M., Sra, S. Statistical estimation for optimization problems on graphs Empirical Inference Symposium, 2011 (poster)

[BibTex]

Transfer Learning with Copulas

Lopez-Paz, D., Hernandez-Lobato, J.

Neural Information Processing Systems (NIPS), 2011 (poster)

PDF [BibTex]

ei Lopez-Paz, D., Hernandez-Lobato, J. Transfer Learning with Copulas Neural Information Processing Systems (NIPS), 2011 (poster)

PDF [BibTex]

Preparation of high-efficiency nanostructures of crystalline silicon at low temperatures, as catalyzed by metals: The decisive role of interface thermodynamics

Wang, Zumin, Jeurgens, Lars P. H., Mittemeijer, Eric J.

2011 (mpi_year_book)

Abstract

Metals may help to convert semiconductors from a disordered (amorphous) to an ordered (crystalline) form at low temperatures. A general, quantitative model description has been developed on the basis of interface thermodynamics, which provides fundamental understanding of such so-called metal-induced crystallization (MIC) of amorphous semiconductors. This fundamental understanding can allow the low-temperature (< 200 ºC) manufacturing of high-efficiency solar cells and crystalline-Si-based nanostructures on cheap and flexible substrates such as glasses, plastics and possibly even papers.

link (url) [BibTex]

Wang, Zumin, Jeurgens, Lars P. H., Mittemeijer, Eric J. Preparation of high-efficiency nanostructures of crystalline silicon at low temperatures, as catalyzed by metals: The decisive role of interface thermodynamics 2011 (mpi_year_book)

link (url) [BibTex]

The sweet coat of living cells – from supramolecular organization and dynamics to biological function

Richter, Ralf

2011 (mpi_year_book)

Abstract

Many biological cells endow themselves with a sugar-rich coat that plays a key role in the protection of the cell and in structuring and communicating with its environment. An outstanding property of these pericellular coats is their dynamic self-organization into strongly hydrated and gel-like meshworks. Tailor-made model systems that are constructed from the molecular building blocks of pericellular coats can help to understand how the coats function.

link (url) [BibTex]

Richter, Ralf The sweet coat of living cells – from supramolecular organization and dynamics to biological function 2011 (mpi_year_book)

link (url) [BibTex]

2005

Kernel methods for dependence testing in LFP-MUA

Gretton, A., Belitski, A., Murayama, Y., Schölkopf, B., Logothetis, N.

35(689.17), 35th Annual Meeting of the Society for Neuroscience (Neuroscience), November 2005 (poster)

Abstract

A fundamental problem in neuroscience is determining whether or not particular neural signals are dependent. The correlation is the most straightforward basis for such tests, but considerable work also focuses on the mutual information (MI), which is capable of revealing dependence of higher orders that the correlation cannot detect. That said, there are other measures of dependence that share with the MI an ability to detect dependence of any order, but which can be easier to compute in practice. We focus in particular on tests based on the functional covariance, which derive from work originally accomplished in 1959 by Renyi. Conceptually, our dependence tests work by computing the covariance between (infinite dimensional) vectors of nonlinear mappings of the observations being tested, and then determining whether this covariance is zero - we call this measure the constrained covariance (COCO). When these vectors are members of universal reproducing kernel Hilbert spaces, we can prove this covariance to be zero only when the variables being tested are independent. The greatest advantage of these tests, compared with the mutual information, is their simplicity – when comparing two signals, we need only take the largest eigenvalue (or the trace) of a product of two matrices of nonlinearities, where these matrices are generally much smaller than the number of observations (and are very simple to construct). We compare the mutual information, the COCO, and the correlation in the context of finding changes in dependence between the LFP and MUA signals in the primary visual cortex of the anaesthetized macaque, during the presentation of dynamic natural stimuli. We demonstrate that the MI and COCO reveal dependence which is not detected by the correlation alone (which we prove by artificially removing all correlation between the signals, and then testing their dependence with COCO and the MI); and that COCO and the MI give results consistent with each other on our data.

Web [BibTex]

2005

ei Gretton, A., Belitski, A., Murayama, Y., Schölkopf, B., Logothetis, N. Kernel methods for dependence testing in LFP-MUA 35(689.17), 35th Annual Meeting of the Society for Neuroscience (Neuroscience), November 2005 (poster)

Web [BibTex]

Rapid animal detection in natural scenes: Critical features are local

Wichmann, F., Rosas, P., Gegenfurtner, K.

Journal of Vision, 5(8):376, Fifth Annual Meeting of the Vision Sciences Society (VSS), September 2005 (poster)

Abstract

Thorpe et al (Nature 381, 1996) first showed how rapidly human observers are able to classify natural images as to whether they contain an animal or not. Whilst the basic result has been replicated using different response paradigms (yes-no versus forced-choice), modalities (eye movements versus button presses) as well as while measuring neurophysiological correlates (ERPs), it is still unclear which image features support this rapid categorisation. Recently Torralba and Oliva (Network: Computation in Neural Systems, 14, 2003) suggested that simple global image statistics can be used to predict seemingly complex decisions about the absence and/or presence of objects in natural scences. They show that the information contained in a small number (N=16) of spectral principal components (SPC)—principal component analysis (PCA) applied to the normalised power spectra of the images—is sufficient to achieve approximately 80% correct animal detection in natural scenes. Our goal was to test whether human observers make use of the power spectrum when rapidly classifying natural scenes. We measured our subjects' ability to detect animals in natural scenes as a function of presentation time (13 to 167 msec); images were immediately followed by a noise mask. In one condition we used the original images, in the other images whose power spectra were equalised (each power spectrum was set to the mean power spectrum over our ensemble of 1476 images). Thresholds for 75% correct animal detection were in the region of 20–30 msec for all observers, independent of the power spectrum of the images: this result makes it very unlikely that human observers make use of the global power spectrum. Taken together with the results of Gegenfurtner, Braun & Wichmann (Journal of Vision [abstract], 2003), showing the robustness of animal detection to global phase noise, we conclude that humans use local features, like edges and contours, in rapid animal detection.

Web DOI [BibTex]

ei Wichmann, F., Rosas, P., Gegenfurtner, K. Rapid animal detection in natural scenes: Critical features are local Journal of Vision, 5(8):376, Fifth Annual Meeting of the Vision Sciences Society (VSS), September 2005 (poster)

Web DOI [BibTex]

Learning an Interest Operator from Eye Movements

Kienzle, W., Franz, M., Wichmann, F., Schölkopf, B.

International Workshop on Bioinspired Information Processing (BIP 2005), 2005, pages: 1, September 2005 (poster)

PDF Web [BibTex]

ei Kienzle, W., Franz, M., Wichmann, F., Schölkopf, B. Learning an Interest Operator from Eye Movements International Workshop on Bioinspired Information Processing (BIP 2005), 2005, pages: 1, September 2005 (poster)

PDF Web [BibTex]

Classification of natural scenes using global image statistics

Drewes, J., Wichmann, F., Gegenfurtner, K.

Journal of Vision, 5(8):602, Fifth Annual Meeting of the Vision Sciences Society (VSS), September 2005 (poster)

Abstract

The algorithmic classification of complex, natural scenes is generally considered a difficult task due to the large amount of information conveyed by natural images. Work by Simon Thorpe and colleagues showed that humans are capable of detecting animals within novel natural scenes with remarkable speed and accuracy. This suggests that the relevant information for classification can be extracted at comparatively limited computational cost. One hypothesis is that global image statistics such as the amplitude spectrum could underly fast image classification (Johnson & Olshausen, Journal of Vision, 2003; Torralba & Oliva, Network: Comput. Neural Syst., 2003). We used linear discriminant analysis to classify a set of 11.000 images into animal and non-animal images. After applying a DFT to the image, we put the Fourier spectrum into bins (8 orientations with 6 frequency bands each). Using all bins, classification performance on the Fourier spectrum reached 70%. However, performance was similar (67%) when only the high spatial frequency information was used and decreased steadily at lower spatial frequencies, reaching a minimum (50%) for the low spatial frequency information. Similar results were obtained when all bins were used on spatially filtered images. A detailed analysis of the classification weights showed that a relatively high level of performance (67%) could also be obtained when only 2 bins were used, namely the vertical and horizontal orientation at the highest spatial frequency band. Our results show that in the absence of sophisticated machine learning techniques, animal detection in natural scenes is limited to rather modest levels of performance, far below those of human observers. If limiting oneself to global image statistics such as the DFT then mostly information at the highest spatial frequencies is useful for the task. This is analogous to the results obtained with human observers on filtered images (Kirchner et al, VSS 2004).

Web DOI [BibTex]

ei Drewes, J., Wichmann, F., Gegenfurtner, K. Classification of natural scenes using global image statistics Journal of Vision, 5(8):602, Fifth Annual Meeting of the Vision Sciences Society (VSS), September 2005 (poster)

Web DOI [BibTex]

Comparative evaluation of Independent Components Analysis algorithms for isolating target-relevant information in brain-signal classification

Hill, N., Schröder, M., Lal, T., Schölkopf, B.

Brain-Computer Interface Technology, 3, pages: 95, June 2005 (poster)

PDF [BibTex]

ei Hill, N., Schröder, M., Lal, T., Schölkopf, B. Comparative evaluation of Independent Components Analysis algorithms for isolating target-relevant information in brain-signal classification Brain-Computer Interface Technology, 3, pages: 95, June 2005 (poster)

PDF [BibTex]

Classification of natural scenes using global image statistics

Drewes, J., Wichmann, F., Gegenfurtner, K.

47, pages: 88, 47. Tagung Experimentell Arbeitender Psychologen, April 2005 (poster)

[BibTex]

ei Drewes, J., Wichmann, F., Gegenfurtner, K. Classification of natural scenes using global image statistics 47, pages: 88, 47. Tagung Experimentell Arbeitender Psychologen, April 2005 (poster)

[BibTex]

Classification of Natural Scenes using Global Image Statistics

Drewes, J., Wichmann, F., Gegenfurtner, K.

8, pages: 88, 8th T{\"u}bingen Perception Conference (TWK), February 2005 (poster)

Abstract

The algorithmic classification of complex, natural scenes is generally considered a difficult task due to the large amount of information conveyed by natural images. Work by Simon Thorpe and colleagues showed that humans are capable of detecting animals within novel natural scenes with remarkable speed and accuracy. This suggests that the relevant information for classification can be extracted at comparatively limited computational cost. One hypothesis is that global image statistics such as the amplitude spectrum could underly fast image classification (Johnson & Olshausen, Journal of Vision, 2003; Torralba & Oliva, Network: Comput. Neural Syst., 2003). We used linear discriminant analysis to classify a set of 11.000 images into animal and nonanimal images. After applying a DFT to the image, we put the Fourier spectrum of each image into 48 bins (8 orientations with 6 frequency bands). Using all of these bins, classification performance on the Fourier spectrum reached 70%. In an iterative procedure, we then removed the bins whose absence caused the smallest damage to the classification performance (one bin per iteration). Notably, performance stayed at about 70% until less then 6 bins were left. A detailed analysis of the classification weights showed that a comparatively high level of performance (67%) could also be obtained when only 2 bins were used, namely the vertical orientations at the highest spatial frequency band. When using only a single frequency band (8 bins) we found that 67% classification performance could be reached when only the high spatial frequency information was used, which decreased steadily at lower spatial frequencies, reaching a minimum (50%) for the low spatial frequency information. Similar results were obtained when all bins were used on spatially pre-filtered images. Our results show that in the absence of sophisticated machine learning techniques, animal detection in natural scenes is limited to rather modest levels of performance, far below those of human observers. If limiting oneself to global image statistics such as the DFT then mostly information at the highest spatial frequencies is useful for the task. This is analogous to the results obtained with human observers on filtered images (Kirchner et al, VSS 2004).

Web [BibTex]

ei Drewes, J., Wichmann, F., Gegenfurtner, K. Classification of Natural Scenes using Global Image Statistics 8, pages: 88, 8th T{\"u}bingen Perception Conference (TWK), February 2005 (poster)

Web [BibTex]

Efficient Adaptive Sampling of the Psychometric Function by Maximizing Information Gain

Tanner, T., Hill, N., Rasmussen, C., Wichmann, F.

8, pages: 109, (Editors: Bülthoff, H. H., H. A. Mallot, R. Ulrich and F. A. Wichmann), 8th T{\"u}bingen Perception Conference (TWK), February 2005 (poster)

Abstract

A psychometric function can be described by its shape and four parameters: position or threshold, slope or width, false alarm rate or chance level, and miss or lapse rate. Depending on the parameters of interest some points on the psychometric function may be more informative than others. Adaptive methods attempt to place trials on the most informative points based on the data collected in previous trials. We introduce a new adaptive bayesian psychometric method which collects data for any set of parameters with high efficency. It places trials by minimizing the expected entropy [1] of the posterior pdf over a set of possible stimuli. In contrast to most other adaptive methods it is neither limited to threshold measurement nor to forced-choice designs. Nuisance parameters can be included in the estimation and lead to less biased estimates. The method supports block designs which do not harm the performance when a sufficient number of trials are performed. Block designs are useful for control of response bias and short term performance shifts such as adaptation. We present the results of evaluations of the method by computer simulations and experiments with human observers. In the simulations we investigated the role of parametric assumptions, the quality of different point estimates, the effect of dynamic termination criteria and many other settings. [1] Kontsevich, L.L. and Tyler, C.W. (1999): Bayesian adaptive estimation of psychometric slope and threshold. Vis. Res. 39 (16), 2729-2737.

Web [BibTex]

ei Tanner, T., Hill, N., Rasmussen, C., Wichmann, F. Efficient Adaptive Sampling of the Psychometric Function by Maximizing Information Gain 8, pages: 109, (Editors: Bülthoff, H. H., H. A. Mallot, R. Ulrich and F. A. Wichmann), 8th T{\"u}bingen Perception Conference (TWK), February 2005 (poster)

Web [BibTex]

Bayesian Inference for Psychometric Functions

Kuss, M., Jäkel, F., Wichmann, F.

8, pages: 106, (Editors: Bülthoff, H. H., H. A. Mallot, R. Ulrich and F. A. Wichmann), 8th T{\"u}bingen Perception Conference (TWK), February 2005 (poster)

Abstract

In psychophysical studies of perception the psychometric function is used to model the relation between the physical stimulus intensity and the observer's ability to detect or discriminate between stimuli of different intensities. We propose the use of Bayesian inference to extract the information contained in experimental data to learn about the parameters of psychometric functions. Since Bayesian inference cannot be performed analytically we use a Markov chain Monte Carlo method to generate samples from the posterior distribution over parameters. These samples can be used to estimate Bayesian confidence intervals and other characteristics of the posterior distribution. We compare our approach with traditional methods based on maximum-likelihood parameter estimation combined with parametric bootstrap techniques for confidence interval estimation. Experiments indicate that Bayesian inference methods are superior to bootstrap-based methods and are thus the method of choice for estimating the psychometric function and its confidence-intervals.

Web [BibTex]

ei Kuss, M., Jäkel, F., Wichmann, F. Bayesian Inference for Psychometric Functions 8, pages: 106, (Editors: Bülthoff, H. H., H. A. Mallot, R. Ulrich and F. A. Wichmann), 8th T{\"u}bingen Perception Conference (TWK), February 2005 (poster)

Web [BibTex]

Global image statistics of natural scenes

Drewes, J., Wichmann, F., Gegenfurtner, K.

Bioinspired Information Processing, 08, pages: 1, 2005 (poster)

[BibTex]

ei Drewes, J., Wichmann, F., Gegenfurtner, K. Global image statistics of natural scenes Bioinspired Information Processing, 08, pages: 1, 2005 (poster)

[BibTex]

Kernel-Methods, Similarity, and Exemplar Theories of Categorization

Jäkel, F., Wichmann, F.

ASIC, 4, 2005 (poster)

Abstract

Kernel-methods are popular tools in machine learning and statistics that can be implemented in a simple feed-forward neural network. They have strong connections to several psychological theories. For example, Shepard‘s universal law of generalization can be given a kernel interpretation. This leads to an inner product and a metric on the psychological space that is different from the usual Minkowski norm. The metric has psychologically interesting properties: It is bounded from above and does not have additive segments. As categorization models often rely on Shepard‘s law as a model for psychological similarity some of them can be recast as kernel-methods. In particular, ALCOVE is shown to be closely related to kernel logistic regression. The relationship to the Generalized Context Model is also discussed. It is argued that functional analysis which is routinely used in machine learning provides valuable insights also for psychology.

Web [BibTex]

ei Jäkel, F., Wichmann, F. Kernel-Methods, Similarity, and Exemplar Theories of Categorization ASIC, 4, 2005 (poster)

Web [BibTex]

Rapid animal detection in natural scenes: critical features are local

Wichmann, F., Rosas, P., Gegenfurtner, K.

Experimentelle Psychologie. Beitr{\"a}ge zur 47. Tagung experimentell arbeitender Psychologen, 47, pages: 225, 2005 (poster)

[BibTex]

ei Wichmann, F., Rosas, P., Gegenfurtner, K. Rapid animal detection in natural scenes: critical features are local Experimentelle Psychologie. Beitr{\"a}ge zur 47. Tagung experimentell arbeitender Psychologen, 47, pages: 225, 2005 (poster)

[BibTex]

The human brain as large margin classifier

Graf, A., Wichmann, F., Bülthoff, H., Schölkopf, B.

Proceedings of the Computational & Systems Neuroscience Meeting (COSYNE), 2, pages: 1, 2005 (poster)

[BibTex]

ei Graf, A., Wichmann, F., Bülthoff, H., Schölkopf, B. The human brain as large margin classifier Proceedings of the Computational & Systems Neuroscience Meeting (COSYNE), 2, pages: 1, 2005 (poster)

[BibTex]

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