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2014


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Exploring complex diseases with intelligent systems

Borgwardt, K.

2014 (mpi_year_book)

Abstract
Physicians are collecting an ever increasing amount of data describing the health state of their patients. Is new knowledge about diseases hidden in this data, which could lead to better therapies? The field of Machine Learning in Biomedicine is concerned with the development of approaches which help to gain such insights from massive biomedical data.

link (url) [BibTex]


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The cellular life-death decision – how mitochondrial membrane proteins can determine cell fate

García-Sáez, Ana J.

2014 (mpi_year_book)

Abstract
Living organisms have a very effective method for eliminating cells that are no longer needed: programmed death. Researchers in the group of Ana García Sáez work with a protein called Bax, a key regulator of apoptosis that creates pores with a flexible diameter inside the outer mitochondrial membrane. This step inevitably triggers the final death of the cell. These insights into the role of important key enzymes in setting off apoptosis could provide useful for developing drugs that can directly influence apoptosis.

link (url) [BibTex]

2011


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Preparation of high-efficiency nanostructures of crystalline silicon at low temperatures, as catalyzed by metals: The decisive role of interface thermodynamics

Wang, Zumin, Jeurgens, Lars P. H., Mittemeijer, Eric J.

2011 (mpi_year_book)

Abstract
Metals may help to convert semiconductors from a disordered (amorphous) to an ordered (crystalline) form at low temperatures. A general, quantitative model description has been developed on the basis of interface thermodynamics, which provides fundamental understanding of such so-called metal-induced crystallization (MIC) of amorphous semiconductors. This fundamental understanding can allow the low-temperature (< 200 ºC) manufacturing of high-efficiency solar cells and crystalline-Si-based nanostructures on cheap and flexible substrates such as glasses, plastics and possibly even papers.

link (url) [BibTex]


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The sweet coat of living cells – from supramolecular organization and dynamics to biological function

Richter, Ralf

2011 (mpi_year_book)

Abstract
Many biological cells endow themselves with a sugar-rich coat that plays a key role in the protection of the cell and in structuring and communicating with its environment. An outstanding property of these pericellular coats is their dynamic self-organization into strongly hydrated and gel-like meshworks. Tailor-made model systems that are constructed from the molecular building blocks of pericellular coats can help to understand how the coats function.

link (url) [BibTex]