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2017


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Local Bayesian Optimization of Motor Skills

Akrour, R., Sorokin, D., Peters, J., Neumann, G.

Proceedings of the 34th International Conference on Machine Learning, 70, pages: 41-50, Proceedings of Machine Learning Research, (Editors: Doina Precup, Yee Whye Teh), PMLR, International Conference on Machine Learning (ICML), August 2017 (conference)

am ei

link (url) Project Page [BibTex]

2017


link (url) Project Page [BibTex]


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Sequence Tutor: Conservative fine-tuning of sequence generation models with KL-control

Jaques, N., Gu, S., Bahdanau, D., Hernández-Lobato, J. M., Turner, R. E., Eck, D.

Proceedings of the 34th International Conference on Machine Learning, 70, pages: 1645-1654, Proceedings of Machine Learning Research, (Editors: Doina Precup, Yee Whye Teh), PMLR, International Conference on Machine Learning (ICML), August 2017 (conference)

ei

Arxiv link (url) Project Page [BibTex]

Arxiv link (url) Project Page [BibTex]


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Lost Relatives of the Gumbel Trick

Balog, M., Tripuraneni, N., Ghahramani, Z., Weller, A.

Proceedings of the 34th International Conference on Machine Learning, 70, pages: 371-379, Proceedings of Machine Learning Research, (Editors: Doina Precup, Yee Whye Teh), PMLR, International Conference on Machine Learning (ICML), August 2017 (conference)

ei

Code link (url) Project Page [BibTex]

Code link (url) Project Page [BibTex]


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Approximate Steepest Coordinate Descent

Stich, S., Raj, A., Jaggi, M.

Proceedings of the 34th International Conference on Machine Learning, 70, pages: 3251-3259, Proceedings of Machine Learning Research, (Editors: Doina Precup, Yee Whye Teh), PMLR, International Conference on Machine Learning (ICML), August 2017 (conference)

ei

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Sparse-then-Dense Alignment based 3D Map Reconstruction Method for Endoscopic Capsule Robots

Turan, M., Yigit Pilavci, Y., Ganiyusufoglu, I., Araujo, H., Konukoglu, E., Sitti, M.

ArXiv e-prints, August 2017 (article)

Abstract
Since the development of capsule endoscopcy technology, substantial progress were made in converting passive capsule endoscopes to robotic active capsule endoscopes which can be controlled by the doctor. However, robotic capsule endoscopy still has some challenges. In particular, the use of such devices to generate a precise and globally consistent three-dimensional (3D) map of the entire inner organ remains an unsolved problem. Such global 3D maps of inner organs would help doctors to detect the location and size of diseased areas more accurately, precisely, and intuitively, thus permitting more accurate and intuitive diagnoses. The proposed 3D reconstruction system is built in a modular fashion including preprocessing, frame stitching, and shading-based 3D reconstruction modules. We propose an efficient scheme to automatically select the key frames out of the huge quantity of raw endoscopic images. Together with a bundle fusion approach that aligns all the selected key frames jointly in a globally consistent way, a significant improvement of the mosaic and 3D map accuracy was reached. To the best of our knowledge, this framework is the first complete pipeline for an endoscopic capsule robot based 3D map reconstruction containing all of the necessary steps for a reliable and accurate endoscopic 3D map. For the qualitative evaluations, a real pig stomach is employed. Moreover, for the first time in literature, a detailed and comprehensive quantitative analysis of each proposed pipeline modules is performed using a non-rigid esophagus gastro duodenoscopy simulator, four different endoscopic cameras, a magnetically activated soft capsule robot (MASCE), a sub-millimeter precise optical motion tracker and a fine-scale 3D optical scanner.

pi

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Causal Consistency of Structural Equation Models

Rubenstein*, P. K., Weichwald*, S., Bongers, S., Mooij, J. M., Janzing, D., Grosse-Wentrup, M., Schölkopf, B.

Proceedings of the 33rd Conference on Uncertainty in Artificial Intelligence (UAI), (Editors: Gal Elidan, Kristian Kersting, and Alexander T. Ihler), Association for Uncertainty in Artificial Intelligence (AUAI), Conference on Uncertainty in Artificial Intelligence (UAI), August 2017, *equal contribution (conference)

ei

Arxiv PDF link (url) [BibTex]

Arxiv PDF link (url) [BibTex]


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Causal Discovery from Temporally Aggregated Time Series

Gong, M., Zhang, K., Schölkopf, B., Glymour, C., Tao, D.

Proceedings Conference on Uncertainty in Artificial Intelligence (UAI) 2017, pages: ID 269, (Editors: Gal Elidan, Kristian Kersting, and Alexander T. Ihler), Association for Uncertainty in Artificial Intelligence (AUAI), Conference on Uncertainty in Artificial Intelligence (UAI), August 2017 (conference)

ei

link (url) [BibTex]

link (url) [BibTex]


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Dipole codes attractively encode glue functions

Ipparthi, D., Mastrangeli, M., Winslow, A.

Theoretical Computer Science, 671, pages: 19 - 25, August 2017, Computational Self-Assembly (article)

Abstract
Dipole words are sequences of magnetic dipoles, in which alike elements repel and opposite elements attract. Magnetic dipoles contrast with more general sets of bonding types, called glues, in which pairwise bonding strength is specified by a glue function. We prove that every glue function g has a set of dipole words, called a dipole code, that attractively encodes g: the pairwise attractions (positive or non-positive bond strength) between the words are identical to those of g. Moreover, we give such word sets of asymptotically optimal length. Similar results are obtained for a commonly used subclass of glue functions.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Causal Discovery from Nonstationary/Heterogeneous Data: Skeleton Estimation and Orientation Determination

Zhang, K., Huang, B., Zhang, J., Glymour, C., Schölkopf, B.

Proceedings of the Twenty-Sixth International Joint Conference on Artificial Intelligence (IJCAI), pages: 1347-1353, (Editors: Carles Sierra), August 2017 (conference)

ei

PDF DOI [BibTex]

PDF DOI [BibTex]


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Hypoxia‐enhanced adhesion of red blood cells in microscale flow

Kim, M., Alapan, Y., Adhikari, A., Little, J. A., Gurkan, U. A.

Microcirculation, 24(5):e12374, July 2017 (article)

Abstract
Abstract Objectives The advancement of microfluidic technology has facilitated the simulation of physiological conditions of the microcirculation, such as oxygen tension, fluid flow, and shear stress in these devices. Here, we present a micro‐gas exchanger integrated with microfluidics to study RBC adhesion under hypoxic flow conditions mimicking postcapillary venules. Methods We simulated a range of physiological conditions and explored RBC adhesion to endothelial or subendothelial components (FN or LN). Blood samples were injected into microchannels at normoxic or hypoxic physiological flow conditions. Quantitative evaluation of RBC adhesion was performed on 35 subjects with homozygous SCD. Results Significant heterogeneity in RBC adherence response to hypoxia was seen among SCD patients. RBCs from a HEA population showed a significantly greater increase in adhesion compared to RBCs from a HNA population, for both FN and LN. Conclusions The approach presented here enabled the control of oxygen tension in blood during microscale flow and the quantification of RBC adhesion in a cost‐efficient and patient‐specific manner. We identified a unique patient population in which RBCs showed enhanced adhesion in hypoxia in vitro. Clinical correlates suggest a more severe clinical phenotype in this subgroup.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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An XY ϴz flexure mechanism with optimal stiffness properties

Lum, G. Z., Pham, M. T., Teo, T. J., Yang, G., Yeo, S. H., Sitti, M.

In 2017 IEEE International Conference on Advanced Intelligent Mechatronics (AIM), pages: 1103-1110, July 2017 (inproceedings)

Abstract
The development of optimal XY θz flexure mechanisms, which can deliver high precision motion about the z-axis, and along the x- and y-axes is highly desirable for a wide range of micro/nano-positioning tasks pertaining to biomedical research, microscopy technologies and various industrial applications. Although maximizing the stiffness ratios is a very critical design requirement, the achievable translational and rotational stiffness ratios of existing XY θz flexure mechanisms are still restricted between 0.5 and 130. As a result, these XY θz flexure mechanisms are unable to fully optimize their workspace and capabilities to reject disturbances. Here, we present an optimal XY θz flexure mechanism, which is designed to have maximum stiffness ratios. Based on finite element analysis (FEA), it has translational stiffness ratio of 248, rotational stiffness ratio of 238 and a large workspace of 2.50 mm × 2.50 mm × 10°. Despite having such a large workspace, FEA also predicts that the proposed mechanism can still achieve a high bandwidth of 70 Hz. In comparison, the bandwidth of similar existing flexure mechanisms that can deflect more than 0.5 mm or 0.5° is typically less than 45 Hz. Hence, the high stiffness ratios of the proposed mechanism are achieved without compromising its dynamic performance. Preliminary experimental results pertaining to the mechanism's translational actuating stiffness and bandwidth were in agreement with the FEA predictions as the deviation was within 10%. In conclusion, the proposed flexure mechanism exhibits superior performance and can be used across a wide range of applications.

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DOI [BibTex]

DOI [BibTex]


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Positioning of drug carriers using permanent magnet-based robotic system in three-dimensional space

Khalil, I. S. M., Alfar, A., Tabak, A. F., Klingner, A., Stramigioli, S., Sitti, M.

In 2017 IEEE International Conference on Advanced Intelligent Mechatronics (AIM), pages: 1117-1122, July 2017 (inproceedings)

Abstract
Magnetic control of drug carriers using systems with open-configurations is essential to enable scaling to the size of in vivo applications. In this study, we demonstrate motion control of paramagnetic microparticles in a low Reynolds number fluid, using a permanent magnet-based robotic system with an open-configuration. The microparticles are controlled in three-dimensional (3D) space using a cylindrical NdFeB magnet that is fixed to the end-effector of a robotic arm. We develop a kinematic map between the position of the microparticles and the configuration of the robotic arm, and use this map as a basis of a closed-loop control system based on the position of the microparticles. Our experimental results show the ability of the robot configuration to control the exerted field gradient on the dipole of the microparticles, and achieve positioning in 3D space with maximum error of 300 µm and 600 µm in the steady-state during setpoint and trajectory tracking, respectively.

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DOI [BibTex]

DOI [BibTex]


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Self-assembly of micro/nanosystems across scales and interfaces

Mastrangeli, M.

In 2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), pages: 676 - 681, IEEE, July 2017 (inproceedings)

Abstract
Steady progress in understanding and implementation are establishing self-assembly as a versatile, parallel and scalable approach to the fabrication of transducers. In this contribution, I illustrate the principles and reach of self-assembly with three applications at different scales - namely, the capillary self-alignment of millimetric components, the sealing of liquid-filled polymeric microcapsules, and the accurate capillary assembly of single nanoparticles - and propose foreseeable directions for further developments.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Flexible Spatio-Temporal Networks for Video Prediction

Lu, C., Hirsch, M., Schölkopf, B.

Proceedings IEEE Conference on Computer Vision and Pattern Recognition (CVPR) 2017, pages: 2137-2145, IEEE, Piscataway, NJ, USA, IEEE Conference on Computer Vision and Pattern Recognition (CVPR), July 2017 (conference)

ei

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Discovering Causal Signals in Images

Lopez-Paz, D., Nishihara, R., Chintala, S., Schölkopf, B., Bottou, L.

Proceedings IEEE Conference on Computer Vision and Pattern Recognition (CVPR) 2017, pages: 58-66, IEEE, Piscataway, NJ, USA, IEEE Conference on Computer Vision and Pattern Recognition (CVPR), July 2017 (conference)

ei

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Dynamic Time-of-Flight

Schober, M., Adam, A., Yair, O., Mazor, S., Nowozin, S.

Proceedings IEEE Conference on Computer Vision and Pattern Recognition (CVPR) 2017, pages: 170-179, IEEE, Piscataway, NJ, USA, IEEE Conference on Computer Vision and Pattern Recognition (CVPR), July 2017 (conference)

ei pn

DOI [BibTex]

DOI [BibTex]


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Strategic exploration in human adaptive control

Schulz, E., Klenske, E., Bramley, N., Speekenbrink, M.

Proceedings of the 39th Annual Conference of the Cognitive Science Society (CogSci), (Editors: Glenn Gunzelmann, Andrew Howes, Thora Tenbrink and Eddy J. Davelaar), cognitivesciencesociety.org, July 2017 (conference)

ei

link (url) [BibTex]

link (url) [BibTex]


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Learning Movement Primitive Libraries through Probabilistic Segmentation

Lioutikov, R., Neumann, G., Maeda, G., Peters, J.

International Journal of Robotics Research, 36(8):879-894, July 2017 (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Dynamic analysis on hexapedal water-running robot with compliant joints

Kim, H., Liu, Y., Jeong, K., Sitti, M., Seo, T.

In 2017 14th International Conference on Ubiquitous Robots and Ambient Intelligence (URAI), pages: 250-251, June 2017 (inproceedings)

Abstract
The dynamic analysis has been considered as one of the important design methods to design robots. In this research, we derive dynamic equation of hexapedal water-running robot to design compliant joints. The compliant joints that connect three bodies will be used to improve mobility and stability of water-running motion's pitch behavior. We considered all of parts as rigid body including links of six Klann mechanisms and three main frames. And then, we derived dynamic equation by using the Lagrangian method with external force of the water. We are expecting that the dynamic analysis is going to be used to design parts of the water running robot.

pi

DOI [BibTex]

DOI [BibTex]


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Soiled adhesive pads shear clean by slipping: a robust self-cleaning mechanism in climbing beetles

Amador, G., Endlein, T., Sitti, M.

Journal of The Royal Society Interface, 14(131):20170134, The Royal Society, June 2017 (article)

Abstract
Animals using adhesive pads to climb smooth surfaces face the problem of keeping their pads clean and functional. Here, a self-cleaning mechanism is proposed whereby soiled feet would slip on the surface due to a lack of adhesion but shed particles in return. Our study offers an in situ quantification of self-cleaning performance in fibrillar adhesives, using the dock beetle as a model organism. After beetles soiled their pads by stepping into patches of spherical beads, we found that their gait was significantly affected. Specifically, soiled pads slipped 10 times further than clean pads, with more particles deposited for longer slips. Like previous studies, we found that particle size affected cleaning performance. Large (45 μm) beads were removed most effectively, followed by medium (10 μm) and small (1 μm). Consistent with our results from climbing beetles, force measurements on freshly severed legs revealed larger detachment forces of medium particles from adhesive pads compared to a flat surface, possibly due to interlocking between fibres. By contrast, dock leaves showed an overall larger affinity to the beads and thus reduced the need for cleaning. Self-cleaning through slippage provides a mechanism robust to particle size and may inspire solutions for artificial adhesives.

pi

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Yield prediction in parallel homogeneous assembly

Ipparthi, D., Winslow, A., Sitti, M., Dorigo, M., Mastrangeli, M.

Soft Matter, 13, pages: 7595-7608, The Royal Society of Chemistry, June 2017 (article)

Abstract
We investigate the parallel assembly of two-dimensional{,} geometrically-closed modular target structures out of homogeneous sets of macroscopic components of varying anisotropy. The yield predicted by a chemical reaction network (CRN)-based model is quantitatively shown to reproduce experimental results over a large set of conditions. Scaling laws for parallel assembling systems are then derived from the model. By extending the validity of the CRN-based modelling{,} this work prompts analysis and solutions to the incompatible substructure problem.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Three‐dimensional patterning in biomedicine: Importance and applications in neuropharmacology

Ajay, V. S., Tanmay, G., Madu, B., Byung‐Wook, P., Thomas, E., Metin, S.

Journal of Biomedical Materials Research Part B: Applied Biomaterials, 106(3):1369-1382, June 2017 (article)

Abstract
Abstract Nature manufactures biological systems in three dimensions with precisely controlled spatiotemporal profiles on hierarchical length and time scales. In this article, we review 3D patterning of biological systems on synthetic platforms for neuropharmacological applications. We briefly describe 3D versus 2D chemical and topographical patterning methods and their limitations. Subsequently, an overview of introducing a third dimension in neuropharmacological research with delineation of chemical and topographical roles is presented. Finally, toward the end of this article, an explanation of how 3D patterning has played a pivotal role in relevant fields of neuropharmacology to understand neurophysiology during development, normal health, and disease conditions is described. The future prospects of organs‐on‐a‐‐like devices to mimic patterned blood–brain barrier in the context of neurotherapeutic discovery and development for the prioritization of lead candidates, membrane potential, and toxicity testing are also described. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1369–1382, 2018.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Tail-Assisted Mobility and Stability Enhancement in Yaw/Pitch Motions of a Water-Running Robot

Kim, H., Sitti, M., Seo, T.

IEEE/ASME Transactions on Mechatronics, 22(3):1207–1217, IEEE, June 2017 (article)

Abstract
Water-running robots have been developed inspired by a basilisk lizard, which demonstrates highly agile, stable, and energy-efficient locomotion on water surfaces. Current water-running robots are not as stable and agile as their biological counterparts. This study shows how the stability of a water-running robot in the pitch direction can be improved by using an active tail to enable increased propulsion. The mobility of the robot is also increased. To generate force in the pitch and yaw directions, a two-degrees-of-freedom tail is implemented with two circular plates to provide drag. We developed two types of dynamic models for pitch and yaw behavior, and the results are recursively calculated by considering the correlation between the models. The relationship between pitch motion and propulsion was analyzed by simulations. The steering behavior of the robot is also validated while considering the pitch behavior. Experiments were conducted to verify the simulation results.

pi

DOI [BibTex]

DOI [BibTex]


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State-Regularized Policy Search for Linearized Dynamical Systems

Abdulsamad, H., Arenz, O., Peters, J., Neumann, G.

Proceedings of the Twenty-Seventh International Conference on Automated Planning and Scheduling, (ICAPS), pages: 419-424, (Editors: Laura Barbulescu, Jeremy Frank, Mausam and Stephen F. Smith), AAAI Press, June 2017 (conference)

ei

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Design and actuation of a magnetic millirobot under a constant unidirectional magnetic field

Erin, O., Giltinan, J., Tsai, L., Sitti, M.

In Proceedings 2017 IEEE International Conference on Robotics and Automation (ICRA), pages: 3404-3410, IEEE, Piscataway, NJ, USA, IEEE International Conference on Robotics and Automation (ICRA), May 2017 (inproceedings)

Abstract
Magnetic untethered millirobots, which are actuated and controlled by remote magnetic fields, have been proposed for medical applications due to their ability to safely pass through tissues at long ranges. For example, magnetic resonance imaging (MRI) systems with a 3-7 T constant unidirectional magnetic field and 3D gradient coils have been used to actuate magnetic robots. Such magnetically constrained systems place limits on the degrees of freedom that can be actuated for untethered devices. This paper presents a design and actuation methodology for a magnetic millirobot that exhibits both position and orientation control in 2D under a magnetic field, dominated by a constant unidirectional magnetic field as found in MRI systems. Placing a spherical permanent magnet, which is free to rotate inside the millirobot and located away from the center of mass, allows the generation of net forces and torques with applied 3D magnetic field gradients. We model this system in a 3D planar case and experimentally demonstrate open-loop control of both position and orientation by the applied 2D field gradients. The actuation performance is characterized across the most important design variables, and we experimentally demonstrate that the proposed approach is feasible.

pi

DOI [BibTex]

DOI [BibTex]


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Deep Reinforcement Learning for Robotic Manipulation with Asynchronous Off-Policy Updates

Gu*, S., Holly*, E., Lillicrap, T., Levine, S.

Proceedings 2017 IEEE International Conference on Robotics and Automation (ICRA), IEEE, Piscataway, NJ, USA, IEEE International Conference on Robotics and Automation (ICRA), May 2017, *equal contribution (conference)

ei

Arxiv Project Page [BibTex]

Arxiv Project Page [BibTex]


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Magnetically actuated soft capsule endoscope for fine-needle aspiration biopsy

Son, D., Dogan, M. D., Sitti, M.

In Proceedings 2017 IEEE International Conference on Robotics and Automation (ICRA), pages: 1132-1139, IEEE, Piscataway, NJ, USA, IEEE International Conference on Robotics and Automation (ICRA), May 2017 (inproceedings)

Abstract
This paper presents a magnetically actuated soft capsule endoscope for fine-needle aspiration biopsy (B-MASCE) in the upper gastrointestinal tract. A thin and hollow needle is attached to the capsule, which can penetrate deeply into tissues to obtain subsurface biopsy sample. The design utilizes a soft elastomer body as a compliant mechanism to guide the needle. An internal permanent magnet provides a means for both actuation and tracking. The capsule is designed to roll towards its target and then deploy the biopsy needle in a precise location selected as the target area. B-MASCE is controlled by multiple custom-designed electromagnets while its position and orientation are tracked by a magnetic sensor array. In in vitro trials, B-MASCE demonstrated rolling locomotion and biopsy of a swine tissue model positioned inside an anatomical human stomach model. It was confirmed after the experiment that a tissue sample was retained inside the needle.

pi

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Propulsion and Chemotaxis in Bacteria-Driven Microswimmers

Zhuang, J., Park, B., Sitti, M.

Advanced Science, 4(9):1700109, May 2017 (article)

Abstract
Despite the large body of experimental work recently on biohybrid microsystems, few studies have focused on theoretical modeling of such systems, which is essential to understand their underlying functioning mechanisms and hence design them optimally for a given application task. Therefore, this study focuses on developing a mathematical model to describe the 3D motion and chemotaxis of a type of widely studied biohybrid microswimmer, where spherical microbeads are driven by multiple attached bacteria. The model is developed based on the biophysical observations of the experimental system and is validated by comparing the model simulation with experimental 3D swimming trajectories and other motility characteristics, including mean squared displacement, speed, diffusivity, and turn angle. The chemotaxis modeling results of the microswimmers also agree well with the experiments, where a collective chemotactic behavior among multiple bacteria is observed. The simulation result implies that such collective chemotaxis behavior is due to a synchronized signaling pathway across the bacteria attached to the same microswimmer. Furthermore, the dependencies of the motility and chemotaxis of the microswimmers on certain system parameters, such as the chemoattractant concentration gradient, swimmer body size, and number of attached bacteria, toward an optimized design of such biohybrid system are studied. The optimized microswimmers would be used in targeted cargo, e.g., drug, imaging agent, gene, and RNA, transport and delivery inside the stagnant or low-velocity fluids of the human body as one of their potential biomedical applications.

pi

DOI Project Page [BibTex]


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Dynamic and programmable self-assembly of micro-rafts at the air-water interface

Wang, W., Giltinan, J., Zakharchenko, S., Sitti, M.

Science Advances, 3(5):e1602522, American Association for the Advancement of Science, May 2017 (article)

Abstract
Dynamic self-assembled material systems constantly consume energy to maintain their spatiotemporal structures and functions. Programmable self-assembly translates information from individual parts to the collective whole. Combining dynamic and programmable self-assembly in a single platform opens up the possibilities to investigate both types of self-assembly simultaneously and to explore their synergy. This task is challenging because of the difficulty in finding suitable interactions that are both dissipative and programmable. We present a dynamic and programmable self-assembling material system consisting of spinning at the air-water interface circular magnetic micro-rafts of radius 50 μm and with cosinusoidal edge-height profiles. The cosinusoidal edge-height profiles not only create a net dissipative capillary repulsion that is sustained by continuous torque input but also enable directional assembly of micro-rafts. We uncover the layered arrangement of micro-rafts in the patterns formed by dynamic self-assembly and offer mechanistic insights through a physical model and geometric analysis. Furthermore, we demonstrate programmable self-assembly and show that a 4-fold rotational symmetry encoded in individual micro-rafts translates into 90° bending angles and square-based tiling in the assembled structures of micro-rafts. We anticipate that our dynamic and programmable material system will serve as a model system for studying nonequilibrium dynamics and statistical mechanics in the future

pi

DOI [BibTex]

DOI [BibTex]


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Presentation of functional groups on self-assembled supramolecular peptide nanofibers mimicking glycosaminoglycans for directed mesenchymal stem cell differentiation

Yasa, O., Uysal, O., Ekiz, M. S., Guler, M. O., Tekinay, A. B.

J. Mater. Chem. B, 5, pages: 4890-4900, The Royal Society of Chemistry, May 2017 (article)

Abstract
Organizational complexity and functional diversity of the extracellular matrix regulate cellular behaviors. The extracellular matrix is composed of various proteins in the form of proteoglycans{,} glycoproteins{,} and nanofibers whose types and combinations change depending on the tissue type. Proteoglycans{,} which are proteins that are covalently attached to glycosaminoglycans{,} contribute to the complexity of the microenvironment of the cells. The sulfation degree of the glycosaminoglycans is an important and distinct feature at specific developmental stages and tissue types. Peptide amphiphile nanofibers can mimic natural glycosaminoglycans and/or proteoglycans{,} and they form a synthetic nanofibrous microenvironment where cells can proliferate and differentiate towards different lineages. In this study{,} peptide nanofibers were used to provide varying degrees of sulfonation mimicking the natural glycosaminoglycans by forming a microenvironment for the survival and differentiation of stem cells. The effects of glucose{,} carboxylate{,} and sulfonate groups on the peptide nanofibers were investigated by considering the changes in the differentiation profiles of rat mesenchymal stem cells in the absence of any specific differentiation inducers in the culture medium. The results showed that a higher sulfonate-to-glucose ratio is associated with adipogenic differentiation and a higher carboxylate-to-glucose ratio is associated with osteochondrogenic differentiation of the rat mesenchymal stem cells. Overall{,} these results demonstrate that supramolecular peptide nanosystems can be used to understand the fine-tunings of the extracellular matrix such as sulfation profile on specific cell types.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


Thumb xl drotlef et al 2017 advanced materials
Bioinspired Composite Microfibers for Skin Adhesion and Signal Amplification of Wearable Sensors

Drotlef, D., Amjadi, M., Yunusa, M., Sitti, M.

Advanced Materials, 29(28):1701353, May 2017, Back Cover (article)

Abstract
A facile approach is proposed for superior conformation and adhesion of wearable sensors to dry and wet skin. Bioinspired skin-adhesive films are composed of elastomeric microfibers decorated with conformal and mushroom-shaped vinylsiloxane tips. Strong skin adhesion is achieved by crosslinking the viscous vinylsiloxane tips directly on the skin surface. Furthermore, composite microfibrillar adhesive films possess a high adhesion strength of 18 kPa due to the excellent shape adaptation of the vinylsiloxane tips to the multiscale roughness of the skin. As a utility of the skin-adhesive films in wearable-device applications, they are integrated with wearable strain sensors for respiratory and heart-rate monitoring. The signal-to-noise ratio of the strain sensor is significantly improved to 59.7 because of the considerable signal amplification of microfibrillar skin-adhesive films.

pi

DOI [BibTex]


Thumb xl mostaghaci et al 2017 advanced science
Bioadhesive Bacterial Microswimmers for Targeted Drug Delivery in the Urinary and Gastrointestinal Tracts

Mostaghaci, B., Yasa, O., Zhuang, J., Sitti, M.

Advanced Science, 4(6):1700058, May 2017 (article)

Abstract
Bacteria-driven biohybrid microswimmers (bacteriabots), which integrate motile bacterial cells and functional synthetic cargo parts (e.g., microparticles encapsulating drug), are recently studied for targeted drug delivery. However, adhesion of such bacteriabots to the tissues on the site of a disease (which can increase the drug delivery efficiency) is not studied yet. Here, this paper proposes an approach to attach bacteriabots to certain types of epithelial cells (expressing mannose on the membrane), based on the affinity between lectin molecules on the tip of bacterial type I pili and mannose molecules on the epithelial cells. It is shown that the bacteria can anchor their cargo particles to mannose-functionalized surfaces and mannose-expressing cells (ATCC HTB-9) using the lectin–mannose bond. The attachment mechanism is confirmed by comparing the adhesion of bacteriabots fabricated from bacterial strains with or without type I pili to mannose-covered surfaces and cells. The proposed bioadhesive motile system can be further improved by expressing more specific adhesion moieties on the membrane of the bacteria.

pi

DOI Project Page [BibTex]


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Six Degree-of-Freedom Localization of Endoscopic Capsule Robots using Recurrent Neural Networks embedded into a Convolutional Neural Network

Turan, M., Abdullah, A., Jamiruddin, R., Araujo, H., Konukoglu, E., Sitti, M.

arXiv preprint arXiv:1705.06196, May 2017 (article)

Abstract
Since its development, ingestible wireless endoscopy is considered to be a painless diagnostic method to detect a number of diseases inside GI tract. Medical related engineering companies have made significant improvements in this technology in last decade; however, some major limitations still residue. Localization of the next generation steerable endoscopic capsule robot in six degreeof-freedom (DoF) and active motion control are some of these limitations. The significance of localization capability concerns with the doctors correct diagnosis of the disease area. This paper presents a very robust 6-DoF localization method based on supervised training of an architecture consisting of recurrent networks (RNN) embedded into a convolutional neural network (CNN) to make use of both just-in-moment information obtained by CNN and correlative information across frames obtained by RNN. To our knowledge, our idea of embedding RNNs into a CNN architecture is for the first time proposed in literature. The experimental results show that the proposed RNN-in-CNN architecture performs very well for endoscopic capsule robot localization in cases vignetting, reflection distortions, noise, sudden camera movements and lack of distinguishable features.

pi

DOI Project Page [BibTex]


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Controllable load sharing for soft adhesive interfaces on three-dimensional surfaces

Song, S., Drotlef, D., Majidi, C., Sitti, M.

Proceedings of the National Academy of Sciences, 114(22):E4344–E4353, National Acad Sciences, May 2017 (article)

Abstract
For adhering to three-dimensional (3D) surfaces or objects, current adhesion systems are limited by a fundamental trade-off between 3D surface conformability and high adhesion strength. This limitation arises from the need for a soft, mechanically compliant interface, which enables conformability to nonflat and irregularly shaped surfaces but significantly reduces the interfacial fracture strength. In this work, we overcome this trade-off with an adhesion-based soft-gripping system that exhibits enhanced fracture strength without sacrificing conformability to nonplanar 3D surfaces. Composed of a gecko-inspired elastomeric microfibrillar adhesive membrane supported by a pressure-controlled deformable gripper body, the proposed soft-gripping system controls the bonding strength by changing its internal pressure and exploiting the mechanics of interfacial equal load sharing. The soft adhesion system can use up to ∼26% of the maximum adhesion of the fibrillar membrane, which is 14× higher than the adhering membrane without load sharing. Our proposed load-sharing method suggests a paradigm for soft adhesion-based gripping and transfer-printing systems that achieves area scaling similar to that of a natural gecko footpad.

pi

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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A Non-Rigid Map Fusion-Based RGB-Depth SLAM Method for Endoscopic Capsule Robots

Turan, M., Almalioglu, Y., Araujo, H., Konukoglu, E., Sitti, M.

arXiv preprint arXiv:1705.05444, May 2017 (article)

Abstract
In the gastrointestinal (GI) tract endoscopy field, ingestible wireless capsule endoscopy is considered as a minimally invasive novel diagnostic technology to inspect the entire GI tract and to diagnose various diseases and pathologies. Since the development of this technology, medical device companies and many groups have made significant progress to turn such passive capsule endoscopes into robotic active capsule endoscopes to achieve almost all functions of current active flexible endoscopes. However, the use of robotic capsule endoscopy still has some challenges. One such challenge is the precise localization of such active devices in 3D world, which is essential for a precise three-dimensional (3D) mapping of the inner organ. A reliable 3D map of the explored inner organ could assist the doctors to make more intuitive and correct diagnosis. In this paper, we propose to our knowledge for the first time in literature a visual simultaneous localization and mapping (SLAM) method specifically developed for endoscopic capsule robots. The proposed RGB-Depth SLAM method is capable of capturing comprehensive dense globally consistent surfel-based maps of the inner organs explored by an endoscopic capsule robot in real time. This is achieved by using dense frame-to-model camera tracking and windowed surfelbased fusion coupled with frequent model refinement through non-rigid surface deformations.

pi

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Context-Driven Movement Primitive Adaptation

Wilbers, D., Lioutikov, R., Peters, J.

IEEE International Conference on Robotics and Automation (ICRA), pages: 3469-3475, IEEE, May 2017 (conference)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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A Learning-based Shared Control Architecture for Interactive Task Execution

Farraj, F. B., Osa, T., Pedemonte, N., Peters, J., Neumann, G., Giordano, P.

IEEE International Conference on Robotics and Automation (ICRA), pages: 329-335, IEEE, May 2017 (conference)

ei

DOI Project Page Project Page [BibTex]

DOI Project Page Project Page [BibTex]


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Frequency Peak Features for Low-Channel Classification in Motor Imagery Paradigms

Jayaram, V., Schölkopf, B., Grosse-Wentrup, M.

Proceedings of the 8th International IEEE/EMBS Conference on Neural Engineering (NER), pages: 321-324, May 2017 (conference)

ei

DOI [BibTex]

DOI [BibTex]


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Empowered skills

Gabriel, A., Akrour, R., Peters, J., Neumann, G.

IEEE International Conference on Robotics and Automation (ICRA), pages: 6435-6441, IEEE, May 2017 (conference)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Layered direct policy search for learning hierarchical skills

End, F., Akrour, R., Peters, J., Neumann, G.

IEEE International Conference on Robotics and Automation (ICRA), pages: 6442-6448, IEEE, May 2017 (conference)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Q-Prop: Sample-Efficient Policy Gradient with An Off-Policy Critic

Gu, S., Lillicrap, T., Ghahramani, Z., Turner, R. E., Levine, S.

Proceedings International Conference on Learning Representations (ICLR), OpenReviews.net, International Conference on Learning Representations, April 2017 (conference)

ei

PDF link (url) Project Page [BibTex]

PDF link (url) Project Page [BibTex]


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Categorical Reparametrization with Gumbel-Softmax

Jang, E., Gu, S., Poole, B.

Proceedings International Conference on Learning Representations 2017, OpenReviews.net, International Conference on Learning Representations, April 2017 (conference)

ei

link (url) [BibTex]

link (url) [BibTex]


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DeepCoder: Learning to Write Programs

Balog, M., Gaunt, A. L., Brockschmidt, M., Nowozin, S., Tarlow, D.

Proceedings International Conference on Learning Representations 2017, OpenReviews.net, International Conference on Learning Representations, April 2017 (conference)

ei

Arxiv link (url) Project Page [BibTex]

Arxiv link (url) Project Page [BibTex]


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Hydrophobic pinning with copper nanowhiskers leads to bactericidal properties

Singh, A. V., Baylan, S., Park, B., Richter, G., Sitti, M.

PloS One, 12(4):e0175428, Public Library of Science, April 2017 (article)

Abstract
The considerable morbidity associated with hospitalized patients and clinics in developed countries due to biofilm formation on biomedical implants and surgical instruments is a heavy economic burden. An alternative to chemically treated surfaces for bactericidal activity started emerging from micro/nanoscale topographical cues in the last decade. Here, we demonstrate a putative antibacterial surface using copper nanowhiskers deposited by molecular beam epitaxy. Furthermore, the control of biological response is based on hydrophobic pinning of water droplets in the Wenzel regime, causing mechanical injury and cell death. Scanning electron microscopy images revealed the details of the surface morphology and non-contact mode laser scanning of the surface revealed the microtopography-associated quantitative parameters. Introducing the bacterial culture over nanowhiskers produces mechanical injury to cells, leading to a reduction in cell density over time due to local pinning of culture medium to whisker surfaces. Extended culture to 72 hours to observe biofilm formation revealed biofilm inhibition with scattered microcolonies and significantly reduced biovolume on nanowhiskers. Therefore, surfaces patterned with copper nanowhiskers can serve as potential antibiofilm surfaces. The topography-based antibacterial surfaces introduce a novel prospect in developing mechanoresponsive nanobiomaterials to reduce the risk of medical device biofilm-associated infections, contrary to chemical leaching of copper as a traditional bactericidal agent.

pi

link (url) [BibTex]

link (url) [BibTex]


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Estimating B0 inhomogeneities with projection FID navigator readouts

Loktyushin, A., Ehses, P., Schölkopf, B., Scheffler, K.

25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM), April 2017 (poster)

ei

link (url) [BibTex]

link (url) [BibTex]


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Distilling Information Reliability and Source Trustworthiness from Digital Traces

Tabibian, B., Valera, I., Farajtabar, M., Song, L., Schölkopf, B., Gomez Rodriguez, M.

Proceedings of the 26th International Conference on World Wide Web (WWW), pages: 847-855, (Editors: Barrett, R., Cummings, R., Agichtein, E. and Gabrilovich, E. ), ACM, April 2017 (conference)

ei

Project DOI Project Page Project Page [BibTex]

Project DOI Project Page Project Page [BibTex]


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Image Quality Improvement by Applying Retrospective Motion Correction on Quantitative Susceptibility Mapping and R2*

Feng, X., Loktyushin, A., Deistung, A., Reichenbach, J.

25th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM), April 2017 (poster)

ei

link (url) [BibTex]

link (url) [BibTex]


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Guiding Trajectory Optimization by Demonstrated Distributions

Osa, T., Ghalamzan E., A. M., Stolkin, R., Lioutikov, R., Peters, J., Neumann, G.

IEEE Robotics and Automation Letters, 2(2):819-826, April 2017 (article)

ei

DOI [BibTex]

DOI [BibTex]


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Local Group Invariant Representations via Orbit Embeddings

Raj, A., Kumar, A., Mroueh, Y., Fletcher, T., Schölkopf, B.

Proceedings of the 20th International Conference on Artificial Intelligence and Statistics (AISTATS), 54, pages: 1225-1235, Proceedings of Machine Learning Research, (Editors: Aarti Singh and Jerry Zhu), April 2017 (conference)

ei

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Whole-body multi-contact motion in humans and humanoids: Advances of the CoDyCo European project

Padois, V., Ivaldi, S., Babic, J., Mistry, M., Peters, J., Nori, F.

Robotics and Autonomous Systems, 90, pages: 97-117, April 2017, Special Issue on New Research Frontiers for Intelligent Autonomous Systems (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]