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2017


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An Interactive Augmented-Reality Video Training Platform for the da Vinci Surgical System

Carlson, J., Kuchenbecker, K. J.

Workshop paper (3 pages) presented at the ICRA Workshop on C4 Surgical Robots, Singapore, May 2017 (misc)

Abstract
Teleoperated surgical robots such as the Intuitive da Vinci Surgical System facilitate minimally invasive surgeries, which decrease risk to patients. However, these systems can be difficult to learn, and existing training curricula on surgical simulators do not offer students the realistic experience of a full operation. This paper presents an augmented-reality video training platform for the da Vinci that will allow trainees to rehearse any surgery recorded by an expert. While the trainee operates a da Vinci in free space, they see their own instruments overlaid on the expert video. Tools are identified in the source videos via color segmentation and kernelized correlation filter tracking, and their depth is calculated from the da Vinci’s stereoscopic video feed. The user tries to follow the expert’s movements, and if any of their tools venture too far away, the system provides instantaneous visual feedback and pauses to allow the user to correct their motion. The trainee can also rewind the expert video by bringing either da Vinci tool very close to the camera. This combined and augmented video provides the user with an immersive and interactive training experience.

hi

[BibTex]

2017


[BibTex]


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Hydrophobic pinning with copper nanowhiskers leads to bactericidal properties

Singh, A. V., Baylan, S., Park, B., Richter, G., Sitti, M.

PloS One, 12(4):e0175428, Public Library of Science, April 2017 (article)

Abstract
The considerable morbidity associated with hospitalized patients and clinics in developed countries due to biofilm formation on biomedical implants and surgical instruments is a heavy economic burden. An alternative to chemically treated surfaces for bactericidal activity started emerging from micro/nanoscale topographical cues in the last decade. Here, we demonstrate a putative antibacterial surface using copper nanowhiskers deposited by molecular beam epitaxy. Furthermore, the control of biological response is based on hydrophobic pinning of water droplets in the Wenzel regime, causing mechanical injury and cell death. Scanning electron microscopy images revealed the details of the surface morphology and non-contact mode laser scanning of the surface revealed the microtopography-associated quantitative parameters. Introducing the bacterial culture over nanowhiskers produces mechanical injury to cells, leading to a reduction in cell density over time due to local pinning of culture medium to whisker surfaces. Extended culture to 72 hours to observe biofilm formation revealed biofilm inhibition with scattered microcolonies and significantly reduced biovolume on nanowhiskers. Therefore, surfaces patterned with copper nanowhiskers can serve as potential antibiofilm surfaces. The topography-based antibacterial surfaces introduce a novel prospect in developing mechanoresponsive nanobiomaterials to reduce the risk of medical device biofilm-associated infections, contrary to chemical leaching of copper as a traditional bactericidal agent.

pi

link (url) [BibTex]

link (url) [BibTex]


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Guiding Trajectory Optimization by Demonstrated Distributions

Osa, T., Ghalamzan E., A. M., Stolkin, R., Lioutikov, R., Peters, J., Neumann, G.

IEEE Robotics and Automation Letters, 2(2):819-826, April 2017 (article)

ei

DOI [BibTex]

DOI [BibTex]


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Whole-body multi-contact motion in humans and humanoids: Advances of the CoDyCo European project

Padois, V., Ivaldi, S., Babic, J., Mistry, M., Peters, J., Nori, F.

Robotics and Autonomous Systems, 90, pages: 97-117, April 2017, Special Issue on New Research Frontiers for Intelligent Autonomous Systems (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Biohybrid microtube swimmers driven by single captured bacteria

Stanton, M. M., Park, B., Miguel-López, A., Ma, X., Sitti, M., Sánchez, S.

Small, 13(19), March 2017 (article)

Abstract
Bacteria biohybrids employ the motility and power of swimming bacteria to carry and maneuver microscale particles. They have the potential to perform microdrug and cargo delivery in vivo, but have been limited by poor design, reduced swimming capabilities, and impeded functionality. To address these challenge, motile Escherichia coli are captured inside electropolymerized microtubes, exhibiting the first report of a bacteria microswimmer that does not utilize a spherical particle chassis. Single bacterium becomes partially trapped within the tube and becomes a bioengine to push the microtube though biological media. Microtubes are modified with “smart” material properties for motion control, including a bacteria-attractant polydopamine inner layer, addition of magnetic components for external guidance, and a biochemical kill trigger to cease bacterium swimming on demand. Swimming dynamics of the bacteria biohybrid are quantified by comparing “length of protrusion” of bacteria from the microtubes with respect to changes in angular autocorrelation and swimmer mean squared displacement. The multifunctional microtubular swimmers present a new generation of biocompatible micromotors toward future microbiorobots and minimally invasive medical applications.

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DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Probabilistic Movement Primitives for Coordination of Multiple Human-Robot Collaborative Tasks

Maeda, G., Neumann, G., Ewerton, M., Lioutikov, R., Kroemer, O., Peters, J.

Autonomous Robots, 41(3):593-612, March 2017 (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Hand-Clapping Games with a Baxter Robot

Fitter, N. T., Kuchenbecker, K. J.

Hands-on demonstration presented at ACM/IEEE International Conference on Human-Robot Interaction (HRI), Vienna, Austria, March 2017 (misc)

Abstract
Robots that work alongside humans might be more effective if they could forge a strong social bond with their human partners. Hand-clapping games and other forms of rhythmic social-physical interaction may foster human-robot teamwork, but the design of such interactions has scarcely been explored. At the HRI 2017 conference, we will showcase several such interactions taken from our recent work with the Rethink Robotics Baxter Research Robot, including tempo-matching, Simon says, and Pat-a-cake-like games. We believe conference attendees will be both entertained and intrigued by this novel demonstration of social-physical HRI.

hi

Project Page [BibTex]

Project Page [BibTex]


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Automatic OSATS Rating of Trainee Skill at a Pediatric Laparoscopic Suturing Task

Oquendo, Y. A., Riddle, E. W., Hiller, D., Blinman, T. A., Kuchenbecker, K. J.

Surgical Endoscopy, 31(Supplement 1):S28, Extended abstract presented as a podium presentation at the Annual Meeting of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), Springer, Houston, USA, March 2017 (misc)

Abstract
Introduction: Minimally invasive surgery has revolutionized surgical practice, but challenges remain. Trainees must acquire complex technical skills while minimizing patient risk, and surgeons must maintain their skills for rare procedures. These challenges are magnified in pediatric surgery due to the smaller spaces, finer tissue, and relative dearth of both inanimate and virtual simulators. To build technical expertise, trainees need opportunities for deliberate practice with specific performance feedback, which is typically provided via tedious human grading. This study aimed to validate a novel motion-tracking system and machine learning algorithm for automatically evaluating trainee performance on a pediatric laparoscopic suturing task using a 1–5 OSATS Overall Skill rating. Methods: Subjects (n=14) ranging from medical students to fellows per- formed one or two trials of an intracorporeal suturing task in a custom pediatric laparoscopy training box (Fig. 1) after watching a video of ideal performance by an expert. The position and orientation of the tools and endoscope were recorded over time using Ascension trakSTAR magnetic motion-tracking sensors, and both instrument grasp angles were recorded over time using flex sensors on the handles. The 27 trials were video-recorded and scored on the OSATS scale by a senior fellow; ratings ranged from 1 to 4. The raw motion data from each trial was processed to calculate over 200 preliminary motion parameters. Regularized least-squares regression (LASSO) was used to identify the most predictive parameters for inclusion in a regression tree. Model performance was evaluated by leave-one-subject-out cross validation, wherein the automatic scores given to each subject’s trials (by a model trained on all other data) are compared to the corresponding human rater scores. Results: The best-performing LASSO algorithm identified 14 predictive parameters for inclusion in the regression tree, including completion time, linear path length, angular path length, angular acceleration, grasp velocity, and grasp acceleration. The final model’s raw output showed a strong positive correlation of 0.87 with the reviewer-generated scores, and rounding the output to the nearest integer yielded a leave-one-subject-out cross-validation accuracy of 77.8%. Results are summarized in the confusion matrix (Table 1). Conclusions: Our novel motion-tracking system and regression model automatically gave previously unseen trials overall skill scores that closely match scores from an expert human rater. With additional data and further development, this system may enable creation of a motion-based training platform for pediatric laparoscopic surgery and could yield insights into the fundamental components of surgical skill.

hi

[BibTex]

[BibTex]


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How Much Haptic Surface Data is Enough?

Burka, A., Kuchenbecker, K. J.

Workshop paper (5 pages) presented at the AAAI Spring Symposium on Interactive Multi-Sensory Object Perception for Embodied Agents, Stanford, USA, March 2017 (misc)

Abstract
The Proton Pack is a portable visuo-haptic surface interaction recording device that will be used to collect a vast multimodal dataset, intended for robots to use as part of an approach to understanding the world around them. In order to collect a useful dataset, we want to pick a suitable interaction duration for each surface, noting the tradeoff between data collection resources and completeness of data. One interesting approach frames the data collection process as an online learning problem, building an incremental surface model and using that model to decide when there is enough data. Here we examine how to do such online surface modeling and when to stop collecting data, using kinetic friction as a first domain in which to apply online modeling.

hi

link (url) Project Page [BibTex]

link (url) Project Page [BibTex]


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Bioinspired tactile sensor for surface roughness discrimination

Yi, Z., Zhang, Y., Peters, J.

Sensors and Actuators A: Physical, 255, pages: 46-53, March 2017 (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Sticky Solution Provides Grip for the First Robotic Pollinator

Amador, G. J., Hu, D. L.

Chem, 2(2):162 - 164, Febuary 2017 (article)

Abstract
Bees, move over. A lily has been pollinated by a remote-controlled flying robot. The robot is hairy, just like a real bee, and sticks to pollen by virtue of an ionic liquid gel, whose fabrication is discussed by Svetlana Chechetka et al. in this issue of Chem.

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link (url) DOI [BibTex]


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Rubbing Against Blood Clots Using Helical Robots: Modeling and In Vitro Experimental Validation

Khalil, I. S., Tabak, A. F., Sadek, K., Mahdy, D., Hamdi, N., Sitti, M.

IEEE Robotics and Automation Letters, 2(2):927-934, IEEE, January 2017 (article)

Abstract
The risk of side effects from thrombolytic agents can be minimized by using smaller doses, assisted by mechanical rubbing against blood clots using helical robots. Quantifying this observation, we study the influence of rubbing against clots on their removal rate in vitro. First, we present a hydrodynamic model of the helical robot based on the resistive-force theory to investigate the rubbing behavior of the clots using robot driven by two rotating dipole fields. Second, we experimentally evaluate the influence of the rubbing on the removal rate of the blood clots. Not only do we find that the removal rate of mechanical rubbing (-0.56 ± 0.27 mm3 /min) is approximately three times greater than the dissolution rate of chemical lysis using streptokinase (-0.17 ± 0.032 mm3/min), but we also show that this removal rate can be controlled via the rubbing speed of the robot.

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DOI [BibTex]

DOI [BibTex]


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Nanoscale topographical control of capillary assembly of nanoparticles

Flauraud, V., Mastrangeli, M., Bernasconi, G., Butet, J., Alexander, D., Shahrabi, E., Martin, O., Brugger, J.

Scientific Reports, Nature Nanotechnology, 12, pages: 73-80, January 2017 (article)

Abstract
Predetermined and selective placement of nanoparticles onto large-area substrates with nanometre-scale precision is essential to harness the unique properties of nanoparticle assemblies, in particular for functional optical and electro-optical nanodevices. Unfortunately, such high spatial organization is currently beyond the reach of top-down nanofabrication techniques alone. Here, we demonstrate that topographic features comprising lithographed funnelled traps and auxiliary sidewalls on a solid substrate can deterministically direct the capillary assembly of Au nanorods to attain simultaneous control of position, orientation and interparticle distance at the nanometre level. We report up to 100% assembly yield over centimetre-scale substrates. We achieve this by optimizing the three sequential stages of capillary nanoparticle assembly: insertion of nanorods into the traps, resilience against the receding suspension front and drying of the residual solvent. Finally, using electron energy-loss spectroscopy we characterize the spectral response and near-field properties of spatially programmable Au nanorod dimers, highlighting the opportunities for precise tunability of the plasmonic modes in larger assemblies.

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DOI [BibTex]

DOI [BibTex]


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Importance of Matching Physical Friction, Hardness, and Texture in Creating Realistic Haptic Virtual Surfaces

Culbertson, H., Kuchenbecker, K. J.

IEEE Transactions on Haptics, 10(1):63-74, January 2017 (article)

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[BibTex]


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Effects of Grip-Force, Contact, and Acceleration Feedback on a Teleoperated Pick-and-Place Task

Khurshid, R. P., Fitter, N. T., Fedalei, E. A., Kuchenbecker, K. J.

IEEE Transactions on Haptics, 10(1):40-53, January 2017 (article)

hi

[BibTex]

[BibTex]


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Multiaxial Polarity Determines Individual Cellular and Nuclear Chirality

Raymond, M. J., Ray, P., Kaur, G., Fredericks, M., Singh, A. V., Wan, L. Q.

Cellular and Molecular Bioengineering, 10(1):63-74, 2017 (article)

Abstract
Intrinsic cell chirality has been implicated in the left--right (LR) asymmetry of embryonic development. Impaired cell chirality could lead to severe birth defects in laterality. Previously, we detected cell chirality with an in vitro micropatterning system. Here, we demonstrate for the first time that chirality can be quantified as the coordination of multiaxial polarization of individual cells and nuclei. Using an object labeling, connected component based method, we characterized cell chirality based on cell and nuclear shape polarization and nuclear positioning of each cell in multicellular patterns of epithelial cells. We found that the cells adopted a LR bias the boundaries by positioning the sharp end towards the leading edge and leaving the nucleus at the rear. This behavior is consistent with the directional migration observed previously on the boundary of micropatterns. Although the nucleus is chirally aligned, it is not strongly biased towards or away from the boundary. As the result of the rear positioning of nuclei, the nuclear positioning has an opposite chirality to that of cell alignment. Overall, our results have revealed deep insights of chiral morphogenesis as the coordination of multiaxial polarization at the cellular and subcellular levels.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Model-based Contextual Policy Search for Data-Efficient Generalization of Robot Skills

Kupcsik, A., Deisenroth, M., Peters, J., Ai Poh, L., Vadakkepat, V., Neumann, G.

Artificial Intelligence, 247, pages: 415-439, 2017, Special Issue on AI and Robotics (article)

ei

link (url) DOI Project Page [BibTex]

link (url) DOI Project Page [BibTex]


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Anticipatory Action Selection for Human-Robot Table Tennis

Wang, Z., Boularias, A., Mülling, K., Schölkopf, B., Peters, J.

Artificial Intelligence, 247, pages: 399-414, 2017, Special Issue on AI and Robotics (article)

Abstract
Abstract Anticipation can enhance the capability of a robot in its interaction with humans, where the robot predicts the humans' intention for selecting its own action. We present a novel framework of anticipatory action selection for human-robot interaction, which is capable to handle nonlinear and stochastic human behaviors such as table tennis strokes and allows the robot to choose the optimal action based on prediction of the human partner's intention with uncertainty. The presented framework is generic and can be used in many human-robot interaction scenarios, for example, in navigation and human-robot co-manipulation. In this article, we conduct a case study on human-robot table tennis. Due to the limited amount of time for executing hitting movements, a robot usually needs to initiate its hitting movement before the opponent hits the ball, which requires the robot to be anticipatory based on visual observation of the opponent's movement. Previous work on Intention-Driven Dynamics Models (IDDM) allowed the robot to predict the intended target of the opponent. In this article, we address the problem of action selection and optimal timing for initiating a chosen action by formulating the anticipatory action selection as a Partially Observable Markov Decision Process (POMDP), where the transition and observation are modeled by the \{IDDM\} framework. We present two approaches to anticipatory action selection based on the \{POMDP\} formulation, i.e., a model-free policy learning method based on Least-Squares Policy Iteration (LSPI) that employs the \{IDDM\} for belief updates, and a model-based Monte-Carlo Planning (MCP) method, which benefits from the transition and observation model by the IDDM. Experimental results using real data in a simulated environment show the importance of anticipatory action selection, and that \{POMDPs\} are suitable to formulate the anticipatory action selection problem by taking into account the uncertainties in prediction. We also show that existing algorithms for POMDPs, such as \{LSPI\} and MCP, can be applied to substantially improve the robot's performance in its interaction with humans.

am ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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easyGWAS: A Cloud-based Platform for Comparing the Results of Genome-wide Association Studies

Grimm, D., Roqueiro, D., Salome, P., Kleeberger, S., Greshake, B., Zhu, W., Liu, C., Lippert, C., Stegle, O., Schölkopf, B., Weigel, D., Borgwardt, K.

The Plant Cell, 29(1):5-19, 2017 (article)

ei

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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A Novel Unsupervised Segmentation Approach Quantifies Tumor Tissue Populations Using Multiparametric MRI: First Results with Histological Validation

Katiyar, P., Divine, M. R., Kohlhofer, U., Quintanilla-Martinez, L., Schölkopf, B., Pichler, B. J., Disselhorst, J. A.

Molecular Imaging and Biology, 19(3):391-397, 2017 (article)

ei

DOI [BibTex]

DOI [BibTex]


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Minimax Estimation of Kernel Mean Embeddings

Tolstikhin, I., Sriperumbudur, B., Muandet, K.

Journal of Machine Learning Research, 18(86):1-47, 2017 (article)

ei

link (url) Project Page [BibTex]


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Kernel Mean Embedding of Distributions: A Review and Beyond

Muandet, K., Fukumizu, K., Sriperumbudur, B., Schölkopf, B.

Foundations and Trends in Machine Learning, 10(1-2):1-141, 2017 (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Prediction of intention during interaction with iCub with Probabilistic Movement Primitives

Dermy, O., Paraschos, A., Ewerton, M., Charpillet, F., Peters, J., Ivaldi, S.

Frontiers in Robotics and AI, 4, pages: 45, 2017 (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Manifold-based multi-objective policy search with sample reuse

Parisi, S., Pirotta, M., Peters, J.

Neurocomputing, 263, pages: 3-14, (Editors: Madalina Drugan, Marco Wiering, Peter Vamplew, and Madhu Chetty), 2017, Special Issue on Multi-Objective Reinforcement Learning (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Spectral Clustering predicts tumor tissue heterogeneity using dynamic 18F-FDG PET: a complement to the standard compartmental modeling approach

Katiyar, P., Divine, M. R., Kohlhofer, U., Quintanilla-Martinez, L., Schölkopf, B., Pichler, B. J., Disselhorst, J. A.

Journal of Nuclear Medicine, 58(4):651-657, 2017 (article)

ei

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Electroencephalographic identifiers of motor adaptation learning

Ozdenizci, O., Yalcin, M., Erdogan, A., Patoglu, V., Grosse-Wentrup, M., Cetin, M.

Journal of Neural Engineering, 14(4):046027, 2017 (article)

ei

link (url) [BibTex]

link (url) [BibTex]


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Gene delivery particle engineering strategies for shape-dependent targeting of cells and tissues.

Kozielski, K., Sitti, M.

Current Gene Therapy, 17, 2017 (article)

Abstract
Background: Successful gene delivery requires overcoming both systemic and intracellular obstacles before the nucleic acid cargo can successfully reach its tissue and subcellular target location. Materials & Methods: Non-viral mechanisms to enable targeting while avoiding off-target delivery have arisen via biological, chemical, and physical engineering strategies. Discussion: Herein we will discuss the physical parameters in particle design that promote tissue- and cell-targeted delivery of genetic cargo. We will discuss systemic concerns, such as circulation, tissue localization, and clearance, as well as cell-scale obstacles, such as cellular uptake and nucleic acid packaging. Conclusion: In particular, we will focus on engineering particle shape and size in order to enhance delivery and promote precise targeting. We will also address methods to program or change particle shape in situ using environmentally triggered cues.

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DOI [BibTex]


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Self-Organized Behavior Generation for Musculoskeletal Robots

Der, R., Martius, G.

Frontiers in Neurorobotics, 11, pages: 8, 2017 (article)

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Detecting distortions of peripherally presented letter stimuli under crowded conditions

Wallis, T. S. A., Tobias, S., Bethge, M., Wichmann, F. A.

Attention, Perception, & Psychophysics, 79(3):850-862, 2017 (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Multi-fractal characterization of bacterial swimming dynamics: a case study on real and simulated Serratia marcescens

Koorehdavoudi, H., Bogdan, P., Wei, G., Marculescu, R., Zhuang, J., Carlsen, R. W., Sitti, M.

Proceedings of the Royal Society of London A: Mathematical, Physical and Engineering Sciences, 473(2203), The Royal Society, 2017 (article)

Abstract
To add to the current state of knowledge about bacterial swimming dynamics, in this paper, we study the fractal swimming dynamics of populations of Serratia marcescens bacteria both in vitro and in silico, while accounting for realistic conditions like volume exclusion, chemical interactions, obstacles and distribution of chemoattractant in the environment. While previous research has shown that bacterial motion is non-ergodic, we demonstrate that, besides the non-ergodicity, the bacterial swimming dynamics is multi-fractal in nature. Finally, we demonstrate that the multi-fractal characteristic of bacterial dynamics is strongly affected by bacterial density and chemoattractant concentration.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Microemulsion-Based Soft Bacteria-Driven Microswimmers for Active Cargo Delivery

Singh, A. V., Hosseinidoust, Z., Park, B., Yasa, O., Sitti, M.

ACS Nano, 0(0):null, 2017, PMID: 28858477 (article)

Abstract
Biohybrid cell-driven microsystems offer unparalleled possibilities for realization of soft microrobots at the micron scale. Here, we introduce a bacteria-driven microswimmer that combines the active locomotion and sensing capabilities of bacteria with the desirable encapsulation and viscoelastic properties of a soft double-micelle microemulsion for active transport and delivery of cargo (e.g., imaging agents, genes, and drugs) to living cells. Quasi-monodisperse double emulsions were synthesized with an aqueous core that encapsulated the fluorescence imaging agents, as a proof-of-concept cargo in this study, and an outer oil shell that was functionalized with streptavidin for specific and stable attachment of biotin-conjugated Escherichia coli. Motile bacteria effectively propelled the soft microswimmers across a Transwell membrane, actively delivering imaging agents (i.e., dyes) encapsulated inside of the micelles to a monolayer of cultured MCF7 breast cancer and J744A.1 macrophage cells, which enabled real-time, live-cell imaging of cell organelles, namely mitochondria, endoplasmic reticulum, and Golgi body. This in vitro model demonstrates the proof-of-concept feasibility of the proposed soft microswimmers and offers promise for potential biomedical applications in active and/or targeted transport and delivery of imaging agents, drugs, stem cells, siRNA, and therapeutic genes to live tissue in in vitro disease models (e.g., organ-on-a-chip devices) and stagnant or low-flow-velocity fluidic regions of the human body.

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link (url) DOI Project Page [BibTex]


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Mode Evolution in Strongly Coupled Plasmonic Dolmens Fabricated by Templated Assembly

Flauraud, V., Bernasconi, G. D., Butet, J., Mastrangeli, M., Alexander, D. T. L., Martin, O. J. F., Brugger, J.

ACS Photonics, 4(7):1661-1668, 2017 (article)

Abstract
Plasmonic antennas have enabled a wealth of applications that exploit tailored near-fields and radiative properties, further endowed by the bespoke interactions of multiple resonant building blocks. Specifically, when the interparticle distances are reduced to a few nanometers, coupling may be greatly enhanced leading to ultimate near-field intensities and confinement along with a large energy splitting of resonant modes. While this concept is well-known, the fabrication and characterization of suitable multimers with controlled geometries and few-nanometer gaps remains highly challenging. In this article, we present the topographically templated assembly of single-crystal colloidal gold nanorods into trimers, with a dolmen geometry. This fabrication method enables the precise positioning of high-quality nanorods, with gaps as small as 1.5 nm, which permits a gradual and controlled symmetry breaking by tuning the arrangement of these strongly coupled nanostructures. To characterize the fabricated structures, we perform electron energy loss spectroscopy (EELS) near-field hyperspectral imaging and geometrically accurate EELS, plane wave, and eigenmode full-wave computations to reveal the principles governing the electromagnetic response of such nanostructures that have been extensively studied under plane wave excitation for their Fano resonant properties. These experiments track the evolution of the multipolar interactions with high accuracy as the antenna geometry varies. Our results provide new insights in strongly coupled single-crystal building blocks and open news opportunities for the design and fabrication of plasmonic systems.

pi

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Temporal evolution of the central fixation bias in scene viewing

Rothkegel, L. O. M., Trukenbrod, H. A., Schütt, H. H., Wichmann, F. A., Engbert, R.

Journal of Vision, 17(13):3, 2017 (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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BundleMAP: Anatomically Localized Classification, Regression, and Hypothesis Testing in Diffusion MRI

Khatami, M., Schmidt-Wilcke, T., Sundgren, P. C., Abbasloo, A., Schölkopf, B., Schultz, T.

Pattern Recognition, 63, pages: 593-600, 2017 (article)

ei

DOI [BibTex]

DOI [BibTex]


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Recent Advances in Skin Penetration Enhancers for Transdermal Gene and Drug Delivery

Amjadia, M., Mostaghacia, B., Sittia, M.

Current Gene Therapy, 17, 2017 (article)

Abstract
There is a growing interest in transdermal delivery systems because of their noninvasive, targeted, and on-demand delivery of gene and drugs. However, efficient penetration of therapeutic compounds into the skin is still challenging largely due to the impermeability of the outermost layer of the skin, known as stratum corneum. Recently, there have been major research activities to enhance the skin penetration depth of pharmacological agents. This article reviews recent advances in the development of various strategies for skin penetration enhancement. We show that approaches such as ultrasound waves, laser, and microneedle patches have successfully been employed to physically disrupt the stratum corneum structure for enhanced transdermal delivery. Rather than physical approaches, several non-physical route have also been utilized for efficient transdermal delivery across the skin barrier. Finally, we discuss some clinical applications of transdermal delivery systems for gene and drug delivery. This paper shows that transdermal delivery devices can potentially function for diverse healthcare and medical applications while further investigations are still necessary for more efficient skin penetration of gene and drugs.

pi

DOI [BibTex]


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A fully dense and globally consistent 3D map reconstruction approach for GI tract to enhance therapeutic relevance of the endoscopic capsule robot

Turan, M., Pilavci, Y. Y., Jamiruddin, R., Araujo, H., Konukoglu, E., Sitti, M.

arXiv preprint arXiv:1705.06524, 2017 (article)

Abstract
In the gastrointestinal (GI) tract endoscopy field, ingestible wireless capsule endoscopy is emerging as a novel, minimally invasive diagnostic technology for inspection of the GI tract and diagnosis of a wide range of diseases and pathologies. Since the development of this technology, medical device companies and many research groups have made substantial progress in converting passive capsule endoscopes to robotic active capsule endoscopes with most of the functionality of current active flexible endoscopes. However, robotic capsule endoscopy still has some challenges. In particular, the use of such devices to generate a precise three-dimensional (3D) mapping of the entire inner organ remains an unsolved problem. Such global 3D maps of inner organs would help doctors to detect the location and size of diseased areas more accurately and intuitively, thus permitting more reliable diagnoses. To our knowledge, this paper presents the first complete pipeline for a complete 3D visual map reconstruction of the stomach. The proposed pipeline is modular and includes a preprocessing module, an image registration module, and a final shape-from-shading-based 3D reconstruction module; the 3D map is primarily generated by a combination of image stitching and shape-from-shading techniques, and is updated in a frame-by-frame iterative fashion via capsule motion inside the stomach. A comprehensive quantitative analysis of the proposed 3D reconstruction method is performed using an esophagus gastro duodenoscopy simulator, three different endoscopic cameras, and a 3D optical scanner.

pi

link (url) Project Page [BibTex]


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A parametric texture model based on deep convolutional features closely matches texture appearance for humans

Wallis, T. S. A., Funke, C. M., Ecker, A. S., Gatys, L. A., Wichmann, F. A., Bethge, M.

Journal of Vision, 17(12), 2017 (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Model Selection for Gaussian Mixture Models

Huang, T., Peng, H., Zhang, K.

Statistica Sinica, 27(1):147-169, 2017 (article)

ei

link (url) [BibTex]

link (url) [BibTex]


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Mobile microrobots for bioengineering applications

Ceylan, H., Giltinan, J., Kozielski, K., Sitti, M.

Lab on a Chip, 17(10):1705-1724, Royal Society of Chemistry, 2017 (article)

Abstract
Untethered micron-scale mobile robots can navigate and non-invasively perform specific tasks inside unprecedented and hard-to-reach inner human body sites and inside enclosed organ-on-a-chip microfluidic devices with live cells. They are aimed to operate robustly and safely in complex physiological environments where they will have a transforming impact in bioengineering and healthcare. Research along this line has already demonstrated significant progress, increasing attention, and high promise over the past several years. The first-generation microrobots, which could deliver therapeutics and other cargo to targeted specific body sites, have just been started to be tested inside small animals toward clinical use. Here, we review frontline advances in design, fabrication, and testing of untethered mobile microrobots for bioengineering applications. We convey the most impactful and recent strategies in actuation, mobility, sensing, and other functional capabilities of mobile microrobots, and discuss their potential advantages and drawbacks to operate inside complex, enclosed and physiologically relevant environments. We lastly draw an outlook to provide directions in the veins of more sophisticated designs and applications, considering biodegradability, immunogenicity, mobility, sensing, and possible medical interventions in complex microenvironments.

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DOI [BibTex]

DOI [BibTex]


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An image-computable psychophysical spatial vision model

Schütt, H. H., Wichmann, F. A.

Journal of Vision, 17(12), 2017 (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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Methods and measurements to compare men against machines

Wichmann, F. A., Janssen, D. H. J., Geirhos, R., Aguilar, G., Schütt, H. H., Maertens, M., Bethge, M.

Electronic Imaging, pages: 36-45(10), 2017 (article)

ei

DOI [BibTex]

DOI [BibTex]


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Surface tension-driven self-alignment

Mastrangeli, M., Zhou, Q., Sariola, V., Lambert, P.

Soft Matter, 13, pages: 304-327, The Royal Society of Chemistry, 2017 (article)

Abstract
Surface tension-driven self-alignment is a passive and highly-accurate positioning mechanism that can significantly simplify and enhance the construction of advanced microsystems. After years of research{,} demonstrations and developments{,} the surface engineering and manufacturing technology enabling capillary self-alignment has achieved a degree of maturity conducive to a successful transfer to industrial practice. In view of this transition{,} a broad and accessible review of the physics{,} material science and applications of capillary self-alignment is presented. Statics and dynamics of the self-aligning action of deformed liquid bridges are explained through simple models and experiments{,} and all fundamental aspects of surface patterning and conditioning{,} of choice{,} deposition and confinement of liquids{,} and of component feeding and interconnection to substrates are illustrated through relevant applications in micro- and nanotechnology. A final outline addresses remaining challenges and additional extensions envisioned to further spread the use and fully exploit the potential of the technique.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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A Comparison of Autoregressive Hidden Markov Models for Multimodal Manipulations With Variable Masses

Kroemer, O., Peters, J.

IEEE Robotics and Automation Letters, 2(2):1101-1108, 2017 (article)

ei

DOI [BibTex]

DOI [BibTex]


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Phase Estimation for Fast Action Recognition and Trajectory Generation in Human-Robot Collaboration

Maeda, G., Ewerton, M., Neumann, G., Lioutikov, R., Peters, J.

International Journal of Robotics Research, 36(13-14):1579-1594, 2017, Special Issue on the Seventeenth International Symposium on Robotics Research (article)

ei

DOI Project Page [BibTex]

DOI Project Page [BibTex]


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A Phase-coded Aperture Camera with Programmable Optics

Chen, J., Hirsch, M., Heintzmann, R., Eberhardt, B., Lensch, H. P. A.

Electronic Imaging, 2017(17):70-75, 2017 (article)

ei

DOI [BibTex]

DOI [BibTex]


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A Deep Learning Based 6 Degree-of-Freedom Localization Method for Endoscopic Capsule Robots

Turan, M., Almalioglu, Y., Konukoglu, E., Sitti, M.

arXiv preprint arXiv:1705.05435, 2017 (article)

Abstract
We present a robust deep learning based 6 degrees-of-freedom (DoF) localization system for endoscopic capsule robots. Our system mainly focuses on localization of endoscopic capsule robots inside the GI tract using only visual information captured by a mono camera integrated to the robot. The proposed system is a 23-layer deep convolutional neural network (CNN) that is capable to estimate the pose of the robot in real time using a standard CPU. The dataset for the evaluation of the system was recorded inside a surgical human stomach model with realistic surface texture, softness, and surface liquid properties so that the pre-trained CNN architecture can be transferred confidently into a real endoscopic scenario. An average error of 7.1% and 3.4% for translation and rotation has been obtained, respectively. The results accomplished from the experiments demonstrate that a CNN pre-trained with raw 2D endoscopic images performs accurately inside the GI tract and is robust to various challenges posed by reflection distortions, lens imperfections, vignetting, noise, motion blur, low resolution, and lack of unique landmarks to track.

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link (url) Project Page [BibTex]