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2019


Thumb xl screenshot 2019 04 08 at 16.22.00
Effect of Remote Masking on Detection of Electrovibration

Jamalzadeh, M., Güçlü, B., Vardar, Y., Basdogan, C.

In Proceedings of the IEEE World Haptics Conference (WHC), Tokyo, Japan, July 2019 (inproceedings) Accepted

Abstract
Masking has been used to study human perception of tactile stimuli, including those created on haptic touch screens. Earlier studies have investigated the effect of in-site masking on tactile perception of electrovibration. In this study, we investigated whether it is possible to change detection threshold of electrovibration at fingertip of index finger via remote masking, i.e. by applying a (mechanical) vibrotactile stimulus on the proximal phalanx of the same finger. The masking stimuli were generated by a voice coil (Haptuator). For eight participants, we first measured the detection thresholds for electrovibration at the fingertip and for vibrotactile stimuli at the proximal phalanx. Then, the vibrations on the skin were measured at four different locations on the index finger of subjects to investigate how the mechanical masking stimulus propagated as the masking level was varied. Finally, electrovibration thresholds measured in the presence of vibrotactile masking stimuli. Our results show that vibrotactile masking stimuli generated sub-threshold vibrations around fingertip, and hence did not mechanically interfere with the electrovibration stimulus. However, there was a clear psychophysical masking effect due to central neural processes. Electrovibration absolute threshold increased approximately 0.19 dB for each dB increase in the masking level.

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[BibTex]

2019


[BibTex]


Thumb xl screenshot 2019 04 08 at 16.08.19
Fingertip Interaction Metrics Correlate with Visual and Haptic Perception of Real Surfaces

Vardar, Y., Wallraven, C., Kuchenbecker, K. J.

In Proceedings of the IEEE World Haptics Conference (WHC), Tokyo, Japan, July 2019 (inproceedings) Accepted

Abstract
Both vision and touch contribute to the perception of real surfaces. Although there have been many studies on the individual contributions of each sense, it is still unclear how each modality’s information is processed and integrated. To fill this gap, we investigated the similarity of visual and haptic perceptual spaces, as well as how well they each correlate with fingertip interaction metrics. Twenty participants interacted with ten different surfaces from the Penn Haptic Texture Toolkit by either looking at or touching them and judged their similarity in pairs. By analyzing the resulting similarity ratings using multi-dimensional scaling (MDS), we found that surfaces are similarly organized within the three-dimensional perceptual spaces of both modalities. Also, between-participant correlations were significantly higher in the haptic condition. In a separate experiment, we obtained the contact forces and accelerations acting on one finger interacting with each surface in a controlled way. We analyzed the collected fingertip interaction data in both the time and frequency domains. Our results suggest that the three perceptual dimensions for each modality can be represented by roughness/smoothness, hardness/softness, and friction, and that these dimensions can be estimated by surface vibration power, tap spectral centroid, and kinetic friction coefficient, respectively.

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Project Page [BibTex]

Project Page [BibTex]


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Haptipedia: Accelerating Haptic Device Discovery to Support Interaction & Engineering Design

Seifi, H., Fazlollahi, F., Oppermann, M., Sastrillo, J. A., Ip, J., Agrawal, A., Park, G., Kuchenbecker, K. J., MacLean, K. E.

In Proceedings of the ACM SIGCHI Conference on Human Factors in Computing Systems (CHI), Glasgow, Scotland, May 2019 (inproceedings) Accepted

Abstract
Creating haptic experiences often entails inventing, modifying, or selecting specialized hardware. However, experience designers are rarely engineers, and 30 years of haptic inventions are buried in a fragmented literature that describes devices mechanically rather than by potential purpose. We conceived of Haptipedia to unlock this trove of examples: Haptipedia presents a device corpus for exploration through metadata that matter to both device and experience designers. It is a taxonomy of device attributes that go beyond physical description to capture potential utility, applied to a growing database of 105 grounded force-feedback devices, and accessed through a public visualization that links utility to morphology. Haptipedia's design was driven by both systematic review of the haptic device literature and rich input from diverse haptic designers. We describe Haptipedia's reception (including hopes it will redefine device reporting standards) and our plans for its sustainability through community participation.

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Project Page [BibTex]

Project Page [BibTex]


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Internal Array Electrodes Improve the Spatial Resolution of Soft Tactile Sensors Based on Electrical Resistance Tomography

Lee, H., Park, K., Kim, J., Kuchenbecker, K. J.

In Proceedings of the IEEE International Conference on Robotics and Automation (ICRA), Montreal, Canada, May 2019 (inproceedings) Accepted

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Project Page [BibTex]

Project Page [BibTex]


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Explorations of Shape-Changing Haptic Interfaces for Blind and Sighted Pedestrian Navigation

Spiers, A., Kuchenbecker, K. J.

pages: 6, Workshop paper (6 pages) presented at the CHI 2019 Workshop on Hacking Blind Navigation, May 2019 (misc) Accepted

Abstract
Since the 1960s, technologists have worked to develop systems that facilitate independent navigation by vision-impaired (VI) pedestrians. These devices vary in terms of conveyed information and feedback modality. Unfortunately, many such prototypes never progress beyond laboratory testing. Conversely, smartphone-based navigation systems for sighted pedestrians have grown in robustness and capabilities, to the point of now being ubiquitous. How can we leverage the success of sighted navigation technology, which is driven by a larger global market, as a way to progress VI navigation systems? We believe one possibility is to make common devices that benefit both VI and sighted individuals, by providing information in a way that does not distract either user from their tasks or environment. To this end we have developed physical interfaces that eschew visual, audio or vibratory feedback, instead relying on the natural human ability to perceive the shape of a handheld object.

hi

[BibTex]

[BibTex]


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Improving Haptic Adjective Recognition with Unsupervised Feature Learning

Richardson, B. A., Kuchenbecker, K. J.

In Proceedings of the IEEE International Conference on Robotics and Automation (ICRA), Montreal, Canada, May 2019 (inproceedings) Accepted

Abstract
Humans can form an impression of how a new object feels simply by touching its surfaces with the densely innervated skin of the fingertips. Many haptics researchers have recently been working to endow robots with similar levels of haptic intelligence, but these efforts almost always employ hand-crafted features, which are brittle, and concrete tasks, such as object recognition. We applied unsupervised feature learning methods, specifically K-SVD and Spatio-Temporal Hierarchical Matching Pursuit (ST-HMP), to rich multi-modal haptic data from a diverse dataset. We then tested the learned features on 19 more abstract binary classification tasks that center on haptic adjectives such as smooth and squishy. The learned features proved superior to traditional hand-crafted features by a large margin, almost doubling the average F1 score across all adjectives. Additionally, particular exploratory procedures (EPs) and sensor channels were found to support perception of certain haptic adjectives, underlining the need for diverse interactions and multi-modal haptic data.

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Project Page [BibTex]

Project Page [BibTex]


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Bimanual Wrist-Squeezing Haptic Feedback Changes Speed-Force Tradeoff in Robotic Surgery Training

Cao, E., Machaca, S., Bernard, T., Wolfinger, B., Patterson, Z., Chi, A., Adrales, G. L., Kuchenbecker, K. J., Brown, J. D.

Extended abstract presented as an ePoster at the Annual Meeting of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), Baltimore, USA, April 2019 (misc) Accepted

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[BibTex]

[BibTex]


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Interactive Augmented Reality for Robot-Assisted Surgery

Forte, M. P., Kuchenbecker, K. J.

Extended abstract presented as an Emerging Technology ePoster at the Annual Meeting of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES), Baltimore, Maryland, USA, April 2019 (misc) Accepted

hi

Project Page [BibTex]

Project Page [BibTex]


Thumb xl m13 bacteriophages
Self-Assembled Phage-Based Colloids for High Localized Enzymatic Activity

Alarcon-Correa, M., Guenther, J., Troll, J., Kadiri, V. M., Bill, J., Fischer, P., Rothenstein, D.

ACS Nano, March 2019 (article)

Abstract
Catalytically active colloids are model systems for chemical motors and active matter. It is desirable to replace the inorganic catalysts and the toxic fuels that are often used, with biocompatible enzymatic reactions. However, compared to inorganic catalysts, enzyme-coated colloids tend to exhibit less activity. Here, we show that the self-assembly of genetically engineered M13 bacteriophages that bind enzymes to magnetic beads ensures high and localized enzymatic activity. These phage-decorated colloids provide a proteinaceous environment for directed enzyme immobilization. The magnetic properties of the colloidal carrier particle permit repeated enzyme recovery from a reaction solution, while the enzymatic activity is retained. Moreover, localizing the phage-based construct with a magnetic field in a microcontainer allows the enzyme-phage-colloids to function as an enzymatic micropump, where the enzymatic reaction generates a fluid flow. This system shows the fastest fluid flow reported to date by a biocompatible enzymatic micropump. In addition, it is functional in complex media including blood where the enzyme driven micropump can be powered at the physiological blood-urea concentration.

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link (url) DOI [BibTex]


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Absolute diffusion measurements of active enzyme solutions by NMR

Guenther, J., Majer, G., Fischer, P.

J. Chem. Phys., 150(124201), March 2019 (article)

Abstract
The diffusion of enzymes is of fundamental importance for many biochemical processes. Enhanced or directed enzyme diffusion can alter the accessibility of substrates and the organization of enzymes within cells. Several studies based on fluorescence correlation spectroscopy (FCS) report enhanced diffusion of enzymes upon interaction with their substrate or inhibitor. In this context, major importance is given to the enzyme fructose-bisphosphate aldolase, for which enhanced diffusion has been reported even though the catalysed reaction is endothermic. Additionally, enhanced diffusion of tracer particles surrounding the active aldolase enzymes has been reported. These studies suggest that active enzymes can act as chemical motors that self-propel and give rise to enhanced diffusion. However, fluorescence studies of enzymes can, despite several advantages, suffer from artefacts. Here we show that the absolute diffusion coefficients of active enzyme solutions can be determined with Pulsed Field Gradient Nuclear Magnetic Resonance (PFG-NMR). The advantage of PFG-NMR is that the motion of the molecule of interest is directly observed in its native state without the need for any labelling. Further, PFG-NMR is model-free and thus yields absolute diffusion constants. Our PFG-NMR experiments of solutions containing active fructose-bisphosphate aldolase from rabbit muscle do not show any diffusion enhancement for the active enzymes nor the surrounding molecules. Additionally, we do not observe any diffusion enhancement of aldolase in the presence of its inhibitor pyrophosphate.

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link (url) DOI [BibTex]


Thumb xl screenshot 2019 02 03 at 19.15.13
A Novel Texture Rendering Approach for Electrostatic Displays

Fiedler, T., Vardar, Y.

In Proceedings of International Workshop on Haptic and Audio Interaction Design (HAID), Lille, France, March 2019 (inproceedings)

Abstract
Generating realistic texture feelings on tactile displays using data-driven methods has attracted a lot of interest in the last decade. However, the need for large data storages and transmission rates complicates the use of these methods for the future commercial displays. In this paper, we propose a new texture rendering approach which can compress the texture data signicantly for electrostatic displays. Using three sample surfaces, we first explain how to record, analyze and compress the texture data, and render them on a touchscreen. Then, through psychophysical experiments conducted with nineteen participants, we show that the textures can be reproduced by a signicantly less number of frequency components than the ones in the original signal without inducing perceptual degradation. Moreover, our results indicate that the possible degree of compression is affected by the surface properties.

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Fiedler19-HAID-Electrostatic [BibTex]

Fiedler19-HAID-Electrostatic [BibTex]


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A Design Tool for Therapeutic Social-Physical Human-Robot Interactions

Mohan, M., Kuchenbecker, K. J.

Workshop paper (3 pages) presented at the HRI Pioneers Workshop, Daegu, South Korea, March 2019 (misc) Accepted

Abstract
We live in an aging society; social-physical human-robot interaction has the potential to keep our elderly adults healthy by motivating them to exercise. After summarizing prior work, this paper proposes a tool that can be used to design exercise and therapy interactions to be performed by an upper-body humanoid robot. The interaction design tool comprises a teleoperation system that transmits the operator’s arm motions, head motions and facial expression along with an interface to monitor and assess the motion of the user interacting with the robot. We plan to use this platform to create dynamic and intuitive exercise interactions.

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Project Page [BibTex]

Project Page [BibTex]


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Chemical Nanomotors at the Gram Scale Form a Dense Active Optorheological Medium

Choudhury, U., Singh, D. P., Qiu, T., Fischer, P.

Adv. Mat., (1807382), Febuary 2019 (article)

Abstract
The rheological properties of a colloidal suspension are a function of the concentration of the colloids and their interactions. While suspensions of passive colloids are well studied and have been shown to form crystals, gels, and glasses, examples of energy‐consuming “active” colloidal suspensions are still largely unexplored. Active suspensions of biological matter, such as motile bacteria or dense mixtures of active actin–motor–protein mixtures have, respectively, reveals superfluid‐like and gel‐like states. Attractive inanimate systems for active matter are chemically self‐propelled particles. It has so far been challenging to use these swimming particles at high enough densities to affect the bulk material properties of the suspension. Here, it is shown that light‐triggered asymmetric titanium dioxide that self‐propel, can be obtained in large quantities, and self‐organize to make a gram‐scale active medium. The suspension shows an activity‐dependent tenfold reversible change in its bulk viscosity.

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link (url) DOI [BibTex]


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First Observation of Optical Activity in Hyper-Rayleigh Scattering

Collins, J., Rusimova, K., Hooper, D., Jeong, H. H., Ohnoutek, L., Pradaux-Caggiano, F., Verbiest, T., Carbery, D., Fischer, P., Valev, V.

Phys. Rev. X, 9(011024), January 2019 (article)

Abstract
Chiral nano- or metamaterials and surfaces enable striking photonic properties, such as negative refractive index and superchiral light, driving promising applications in novel optical components, nanorobotics, and enhanced chiral molecular interactions with light. In characterizing chirality, although nonlinear chiroptical techniques are typically much more sensitive than their linear optical counterparts, separating true chirality from anisotropy is a major challenge. Here, we report the first observation of optical activity in second-harmonic hyper-Rayleigh scattering (HRS). We demonstrate the effect in a 3D isotropic suspension of Ag nanohelices in water. The effect is 5 orders of magnitude stronger than linear optical activity and is well pronounced above the multiphoton luminescence background. Because of its sensitivity, isotropic environment, and straightforward experimental geometry, HRS optical activity constitutes a fundamental experimental breakthrough in chiral photonics for media including nanomaterials, metamaterials, and chemical molecules.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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The Perception of Ultrasonic Square Reductions of Friction With Variable Sharpness and Duration

Gueorguiev, D., Vezzoli, E., Sednaoui, T., Grisoni, L., Lemaire-Semail, B.

IEEE Transactions on Haptics, 12(2):179-188, January 2019 (article)

Abstract
The human perception of square ultrasonic modulation of the finger-surface friction was investigated during active tactile exploration by using short frictional cues of varying duration and sharpness. In a first experiment, we asked participants to discriminate the transition time and duration of short square ultrasonic reductions of friction. They proved very sensitive to discriminate millisecond differences in these two parameters with the average psychophysical thresholds being 2.3–2.4 ms for both parameters. A second experiment focused on the perception of square friction reductions with variable transition times and durations. We found that for durations of the stimulation larger than 90 ms, participants often perceived three or four edges when only two stimulations were presented while they consistently felt two edges for signals shorter than 50 ms. A subsequent analysis of the contact forces induced by these ultrasonic stimulations during slow and fast active exploration showed that two identical consecutive ultrasonic pulses can induce significantly different frictional dynamics especially during fast motion of the finger. These results confirm the human sensitivity to transient frictional cues and suggest that the human perception of square reductions of friction can depend on their sharpness and duration as well as on the speed of exploration.

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DOI [BibTex]

DOI [BibTex]


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How Does It Feel to Clap Hands with a Robot?

Fitter, N. T., Kuchenbecker, K. J.

International Journal of Social Robotics, 2019 (article) Accepted

Abstract
Future robots may need lighthearted physical interaction capabilities to connect with people in meaningful ways. To begin exploring how users perceive playful human–robot hand-to-hand interaction, we conducted a study with 20 participants. Each user played simple hand-clapping games with the Rethink Robotics Baxter Research Robot during a 1-h-long session involving 24 randomly ordered conditions that varied in facial reactivity, physical reactivity, arm stiffness, and clapping tempo. Survey data and experiment recordings demonstrate that this interaction is viable: all users successfully completed the experiment and mentioned enjoying at least one game without prompting. Hand-clapping tempo was highly salient to users, and human-like robot errors were more widely accepted than mechanical errors. Furthermore, perceptions of Baxter varied in the following statistically significant ways: facial reactivity increased the robot’s perceived pleasantness and energeticness; physical reactivity decreased pleasantness, energeticness, and dominance; higher arm stiffness increased safety and decreased dominance; and faster tempo increased energeticness and increased dominance. These findings can motivate and guide roboticists who want to design social–physical human–robot interactions.

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[BibTex]

[BibTex]


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Microrobotics and Microorganisms: Biohybrid Autonomous Cellular Robots

Alapan, Y., Yasa, O., Yigit, B., Yasa, I. C., Erkoc, P., Sitti, M.

Annual Review of Control, Robotics, and Autonomous Systems, 2019 (article)

pi

[BibTex]

[BibTex]


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X-ray Optics Fabrication Using Unorthodox Approaches

Sanli, U., Baluktsian, M., Ceylan, H., Sitti, M., Weigand, M., Schütz, G., Keskinbora, K.

Bulletin of the American Physical Society, APS, 2019 (article)

mms pi

[BibTex]

[BibTex]


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The near and far of a pair of magnetic capillary disks

Koens, L., Wang, W., Sitti, M., Lauga, E.

Soft Matter, 2019 (article)

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[BibTex]

[BibTex]


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Toward Expert-Sourcing of a Haptic Device Repository

Seifi, H., Ip, J., Agrawal, A., Kuchenbecker, K. J., MacLean, K. E.

Glasgow, UK, 2019 (misc)

Abstract
Haptipedia is an online taxonomy, database, and visualization that aims to accelerate ideation of new haptic devices and interactions in human-computer interaction, virtual reality, haptics, and robotics. The current version of Haptipedia (105 devices) was created through iterative design, data entry, and evaluation by our team of experts. Next, we aim to greatly increase the number of devices and keep Haptipedia updated by soliciting data entry and verification from haptics experts worldwide.

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[BibTex]

[BibTex]


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Review of emerging concepts in nanotoxicology: opportunities and challenges for safer nanomaterial design

Singh, A. V., Laux, P., Luch, A., Sudrik, C., Wiehr, S., Wild, A., Santamauro, G., Bill, J., Sitti, M.

Toxicology Mechanisms and Methods, 2019 (article)

pi

[BibTex]

[BibTex]


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Graphene oxide synergistically enhances antibiotic efficacy in Vancomycin resistance Staphylococcus aureus

Singh, V., Kumar, V., Kashyap, S., Singh, A. V., Kishore, V., Sitti, M., Saxena, P. S., Srivastava, A.

ACS Applied Bio Materials, ACS Publications, 2019 (article)

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[BibTex]

[BibTex]


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Microfluidics Integrated Lithography‐Free Nanophotonic Biosensor for the Detection of Small Molecules

Sreekanth, K. V., Sreejith, S., Alapan, Y., Sitti, M., Lim, C. T., Singh, R.

Advanced Optical Materials, 2019 (article)

pi

[BibTex]

[BibTex]


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Mobile microrobots for active therapeutic delivery

Erkoc, P., Yasa, I. C., Ceylan, H., Yasa, O., Alapan, Y., Sitti, M.

Advanced Therapeutics, Wiley Online Library, 2019 (article)

pi

[BibTex]

[BibTex]


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Electromechanical actuation of dielectric liquid crystal elastomers for soft robotics

Davidson, Z., Shahsavan, H., Guo, Y., Hines, L., Xia, Y., Yang, S., Sitti, M.

Bulletin of the American Physical Society, APS, 2019 (article)

pi

[BibTex]

[BibTex]

2018


Thumb xl toc image
Role of symmetry in driven propulsion at low Reynolds number

Sachs, J., Morozov, K. I., Kenneth, O., Qiu, T., Segreto, N., Fischer, P., Leshansky, A. M.

Phys. Rev. E, 98(6):063105, American Physical Society, December 2018 (article)

Abstract
We theoretically and experimentally investigate low-Reynolds-number propulsion of geometrically achiral planar objects that possess a dipole moment and that are driven by a rotating magnetic field. Symmetry considerations (involving parity, $\widehat{P}$, and charge conjugation, $\widehat{C}$) establish correspondence between propulsive states depending on orientation of the dipolar moment. Although basic symmetry arguments do not forbid individual symmetric objects to efficiently propel due to spontaneous symmetry breaking, they suggest that the average ensemble velocity vanishes. Some additional arguments show, however, that highly symmetrical ($\widehat{P}$-even) objects exhibit no net propulsion while individual less symmetrical ($\widehat{C}\widehat{P}$-even) propellers do propel. Particular magnetization orientation, rendering the shape $\widehat{C}\widehat{P}$-odd, yields unidirectional motion typically associated with chiral structures, such as helices. If instead of a structure with a permanent dipole we consider a polarizable object, some of the arguments have to be modified. For instance, we demonstrate a truly achiral ($\widehat{P}$- and $\widehat{C}\widehat{P}$-even) planar shape with an induced electric dipole that can propel by electro-rotation. We thereby show that chirality is not essential for propulsion due to rotation-translation coupling at low Reynolds number.

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link (url) DOI Project Page [BibTex]

2018


link (url) DOI Project Page [BibTex]


Thumb xl screenshot 2018 5 9 swimming back and forth using planar flagellar propulsion at low reynolds numbers   khalil   2018   adv ...
Swimming Back and Forth Using Planar Flagellar Propulsion at Low Reynolds Numbers

Khalil, I. S. M., Tabak, A. F., Hamed, Y., Mitwally, M. E., Tawakol, M., Klingner, A., Sitti, M.

Advanced Science, 5(2):1700461, 2018 (article)

Abstract
Abstract Peritrichously flagellated Escherichia coli swim back and forth by wrapping their flagella together in a helical bundle. However, other monotrichous bacteria cannot swim back and forth with a single flagellum and planar wave propagation. Quantifying this observation, a magnetically driven soft two‐tailed microrobot capable of reversing its swimming direction without making a U‐turn trajectory or actively modifying the direction of wave propagation is designed and developed. The microrobot contains magnetic microparticles within the polymer matrix of its head and consists of two collinear, unequal, and opposite ultrathin tails. It is driven and steered using a uniform magnetic field along the direction of motion with a sinusoidally varying orthogonal component. Distinct reversal frequencies that enable selective and independent excitation of the first or the second tail of the microrobot based on their tail length ratio are found. While the first tail provides a propulsive force below one of the reversal frequencies, the second is almost passive, and the net propulsive force achieves flagellated motion along one direction. On the other hand, the second tail achieves flagellated propulsion along the opposite direction above the reversal frequency.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Optical and Thermophoretic Control of Janus Nanopen Injection into Living Cells

Maier, C. M., Huergo, M. A., Milosevic, S., Pernpeintner, C., Li, M., Singh, D. P., Walker, D., Fischer, P., Feldmann, J., Lohmüller, T.

Nano Letters, 18, pages: 7935–7941, November 2018 (article) Accepted

Abstract
Devising strategies for the controlled injection of functional nanoparticles and reagents into living cells paves the way for novel applications in nanosurgery, sensing, and drug delivery. Here, we demonstrate the light-controlled guiding and injection of plasmonic Janus nanopens into living cells. The pens are made of a gold nanoparticle attached to a dielectric alumina shaft. Balancing optical and thermophoretic forces in an optical tweezer allows single Janus nanopens to be trapped and positioned on the surface of living cells. While the optical injection process involves strong heating of the plasmonic side, the temperature of the alumina stays significantly lower, thus allowing the functionalization with fluorescently labeled, single-stranded DNA and, hence, the spatially controlled injection of genetic material with an untethered nanocarrier.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


Thumb xl content nanoroboter werden ins auge injiziert
A swarm of slippery micropropellers penetrates the vitreous body of the eye

Wu, Z., Troll, J., Jeong, H. H., Wei, Q., Stang, M., Ziemssen, F., Wang, Z., Dong, M., Schnichels, S., Qiu, T., Fischer, P.

Science Advances, 4(11):eaat4388, November 2018 (article)

Abstract
The intravitreal delivery of therapeutic agents promises major benefits in the field of ocular medicine. Traditional delivery methods rely on the random, passive diffusion of molecules, which do not allow for the rapid delivery of a concentrated cargo to a defined region at the posterior pole of the eye. The use of particles promises targeted delivery but faces the challenge that most tissues including the vitreous have a tight macromolecular matrix that acts as a barrier and prevents its penetration. Here, we demonstrate novel intravitreal delivery microvehicles slippery micropropellers that can be actively propelled through the vitreous humor to reach the retina. The propulsion is achieved by helical magnetic micropropellers that have a liquid layer coating to minimize adhesion to the surrounding biopolymeric network. The submicrometer diameter of the propellers enables the penetration of the biopolymeric network and the propulsion through the porcine vitreous body of the eye over centimeter distances. Clinical optical coherence tomography is used to monitor the movement of the propellers and confirm their arrival on the retina near the optic disc. Overcoming the adhesion forces and actively navigating a swarm of micropropellers in the dense vitreous humor promise practical applications in ophthalmology.

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Video: Nanorobots propel through the eye link (url) DOI [BibTex]

Video: Nanorobots propel through the eye link (url) DOI [BibTex]


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Reducing 3D Vibrations to 1D in Real Time

Park, G., Kuchenbecker, K. J.

Hands-on demonstration (4 pages) presented at AsiaHaptics, Incheon, South Korea, November 2018 (misc)

Abstract
For simple and realistic vibrotactile feedback, 3D accelerations from real contact interactions are usually rendered using a single-axis vibration actuator; this dimensional reduction can be performed in many ways. This demonstration implements a real-time conversion system that simultaneously measures 3D accelerations and renders corresponding 1D vibrations using a two-pen interface. In the demonstration, a user freely interacts with various objects using an In-Pen that contains a 3-axis accelerometer. The captured accelerations are converted to a single-axis signal, and an Out-Pen renders the reduced signal for the user to feel. We prepared seven conversion methods from the simple use of a single-axis signal to applying principal component analysis (PCA) so that users can compare the performance of each conversion method in this demonstration.

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Project Page [BibTex]

Project Page [BibTex]


Thumb xl representative image2
A Large-Scale Fabric-Based Tactile Sensor Using Electrical Resistance Tomography

Lee, H., Park, K., Kim, J., Kuchenbecker, K. J.

Hands-on demonstration (3 pages) presented at AsiaHaptics, Incheon, South Korea, November 2018 (misc)

Abstract
Large-scale tactile sensing is important for household robots and human-robot interaction because contacts can occur all over a robot’s body surface. This paper presents a new fabric-based tactile sensor that is straightforward to manufacture and can cover a large area. The tactile sensor is made of conductive and non-conductive fabric layers, and the electrodes are stitched with conductive thread, so the resulting device is flexible and stretchable. The sensor utilizes internal array electrodes and a reconstruction method called electrical resistance tomography (ERT) to achieve a high spatial resolution with a small number of electrodes. The developed sensor shows that only 16 electrodes can accurately estimate single and multiple contacts over a square that measures 20 cm by 20 cm.

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Project Page [BibTex]

Project Page [BibTex]


Thumb xl universal custom complex magnetic spring design methodology
Universal Custom Complex Magnetic Spring Design Methodology

Woodward, M. A., Sitti, M.

IEEE Transactions on Magnetics, 54(1):1-13, October 2018 (article)

Abstract
A design methodology is presented for creating custom complex magnetic springs through the design of force-displacement curves. This methodology results in a magnet configuration, which will produce a desired force-displacement relationship. Initially, the problem is formulated and solved as a system of linear equations. Then, given the limited likelihood of a single solution being feasibly manufactured, key parameters of the solution are extracted and varied to create a family of solutions. Finally, these solutions are refined using numerical optimization. Given the properties of magnets, this methodology can create any well-defined function of force versus displacement and is model-independent. To demonstrate this flexibility, a number of example magnetic springs are designed; one of which, designed for use in a jumping-gliding robot's shape memory alloy actuated clutch, is manufactured and experimentally characterized. Due to the scaling of magnetic forces, the displacement region which these magnetic springs are most applicable is that of millimeters and below. However, this region is well situated for miniature robots and smart material actuators, where a tailored magnetic spring, designed to compliment a component, can enhance its performance while adding new functionality. The methodology is also expendable to variable interactions and multi-dimensional magnetic field design.

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DOI [BibTex]

DOI [BibTex]


Thumb xl toc image
Gait learning for soft microrobots controlled by light fields

Rohr, A. V., Trimpe, S., Marco, A., Fischer, P., Palagi, S.

In International Conference on Intelligent Robots and Systems (IROS) 2018, pages: 6199-6206, International Conference on Intelligent Robots and Systems 2018, October 2018 (inproceedings)

Abstract
Soft microrobots based on photoresponsive materials and controlled by light fields can generate a variety of different gaits. This inherent flexibility can be exploited to maximize their locomotion performance in a given environment and used to adapt them to changing environments. However, because of the lack of accurate locomotion models, and given the intrinsic variability among microrobots, analytical control design is not possible. Common data-driven approaches, on the other hand, require running prohibitive numbers of experiments and lead to very sample-specific results. Here we propose a probabilistic learning approach for light-controlled soft microrobots based on Bayesian Optimization (BO) and Gaussian Processes (GPs). The proposed approach results in a learning scheme that is highly data-efficient, enabling gait optimization with a limited experimental budget, and robust against differences among microrobot samples. These features are obtained by designing the learning scheme through the comparison of different GP priors and BO settings on a semisynthetic data set. The developed learning scheme is validated in microrobot experiments, resulting in a 115% improvement in a microrobot’s locomotion performance with an experimental budget of only 20 tests. These encouraging results lead the way toward self-adaptive microrobotic systems based on lightcontrolled soft microrobots and probabilistic learning control.

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arXiv IEEE Xplore DOI Project Page [BibTex]

arXiv IEEE Xplore DOI Project Page [BibTex]


Thumb xl encyclop med robotics
Nanoscale robotic agents in biological fluids and tissues

Palagi, S., Walker, D. Q. T., Fischer, P.

In The Encyclopedia of Medical Robotics, 2, pages: 19-42, 2, (Editors: Desai, J. P. and Ferreira, A.), World Scientific, October 2018 (inbook)

Abstract
Nanorobots are untethered structures of sub-micron size that can be controlled in a non-trivial way. Such nanoscale robotic agents are envisioned to revolutionize medicine by enabling minimally invasive diagnostic and therapeutic procedures. To be useful, nanorobots must be operated in complex biological fluids and tissues, which are often difficult to penetrate. In this chapter, we first discuss potential medical applications of motile nanorobots. We briefly present the challenges related to swimming at such small scales and we survey the rheological properties of some biological fluids and tissues. We then review recent experimental results in the development of nanorobots and in particular their design, fabrication, actuation, and propulsion in complex biological fluids and tissues. Recent work shows that their nanoscale dimension is a clear asset for operation in biological tissues, since many biological tissues consist of networks of macromolecules that prevent the passage of larger micron-scale structures, but contain dynamic pores through which nanorobots can move.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Softness, Warmth, and Responsiveness Improve Robot Hugs

Block, A. E., Kuchenbecker, K. J.

International Journal of Social Robotics, 11(1):49-64, October 2018 (article)

Abstract
Hugs are one of the first forms of contact and affection humans experience. Due to their prevalence and health benefits, roboticists are naturally interested in having robots one day hug humans as seamlessly as humans hug other humans. This project's purpose is to evaluate human responses to different robot physical characteristics and hugging behaviors. Specifically, we aim to test the hypothesis that a soft, warm, touch-sensitive PR2 humanoid robot can provide humans with satisfying hugs by matching both their hugging pressure and their hugging duration. Thirty relatively young and rather technical participants experienced and evaluated twelve hugs with the robot, divided into three randomly ordered trials that focused on physical robot characteristics (single factor, three levels) and nine randomly ordered trials with low, medium, and high hug pressure and duration (two factors, three levels each). Analysis of the results showed that people significantly prefer soft, warm hugs over hard, cold hugs. Furthermore, users prefer hugs that physically squeeze them and release immediately when they are ready for the hug to end. Taking part in the experiment also significantly increased positive user opinions of robots and robot use.

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link (url) DOI Project Page [BibTex]

link (url) DOI Project Page [BibTex]


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Fast spatial scanning of 3D ultrasound fields via thermography

Melde, K., Qiu, T., Fischer, P.

Applied Physics Letters, 113(13):133503, September 2018 (article)

Abstract
We propose and demonstrate a thermographic method that allows rapid scanning of ultrasound fields in a volume to yield 3D maps of the sound intensity. A thin sound-absorbing membrane is continuously translated through a volume of interest while a thermal camera records the evolution of its surface temperature. The temperature rise is a function of the absorbed sound intensity, such that the thermal image sequence can be combined to reveal the sound intensity distribution in the traversed volume. We demonstrate the mapping of ultrasound fields, which is several orders of magnitude faster than scanning with a hydrophone. Our results are in very good agreement with theoretical simulations.

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link (url) DOI Project Page [BibTex]


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Diffusion Measurements of Swimming Enzymes with Fluorescence Correlation Spectroscopy

Günther, J., Börsch, M., Fischer, P.

Accounts of Chemical Research, 51(9):1911-1920, August 2018 (article)

Abstract
Self-propelled chemical motors are chemically powered micro- or nanosized swimmers. The energy required for these motors’ active motion derives from catalytic chemical reactions and the transformation of a fuel dissolved in the solution. While self-propulsion is now well established for larger particles, it is still unclear if enzymes, nature’s nanometer-sized catalysts, are potentially also self-powered nanomotors. Because of its small size, any increase in an enzyme’s diffusion due to active self-propulsion must be observed on top of the enzyme’s passive Brownian motion, which dominates at this scale. Fluorescence correlation spectroscopy (FCS) is a sensitive method to quantify the diffusion properties of single fluorescently labeled molecules in solution. FCS experiments have shown a general increase in the diffusion constant of a number of enzymes when the enzyme is catalytically active. Diffusion enhancements after addition of the enzyme’s substrate (and sometimes its inhibitor) of up to 80\% have been reported, which is at least 1 order of magnitude higher than what theory would predict. However, many factors contribute to the FCS signal and in particular the shape of the autocorrelation function, which underlies diffusion measurements by fluorescence correlation spectroscopy. These effects need to be considered to establish if and by how much the catalytic activity changes an enzyme’s diffusion.We carefully review phenomena that can play a role in FCS experiments and the determination of enzyme diffusion, including the dissociation of enzyme oligomers upon interaction with the substrate, surface binding of the enzyme to glass during the experiment, conformational changes upon binding, and quenching of the fluorophore. We show that these effects can cause changes in the FCS signal that behave similar to an increase in diffusion. However, in the case of the enzymes F1-ATPase and alkaline phosphatase, we demonstrate that there is no measurable increase in enzyme diffusion. Rather, dissociation and conformational changes account for the changes in the FCS signal in the former and fluorophore quenching in the latter. Within the experimental accuracy of our FCS measurements, we do not observe any change in diffusion due to activity for the enzymes we have investigated.We suggest useful control experiments and additional tests for future FCS experiments that should help establish if the observed diffusion enhancement is real or if it is due to an experimental or data analysis artifact. We show that fluorescence lifetime and mean intensity measurements are essential in order to identify the nature of the observed changes in the autocorrelation function. While it is clear from theory that chemically active enzymes should also act as self-propelled nanomotors, our FCS measurements show that the associated increase in diffusion is much smaller than previously reported. Further experiments are needed to quantify the contribution of the enzymes’ catalytic activity to their self-propulsion. We hope that our findings help to establish a useful protocol for future FCS studies in this field and help establish by how much the diffusion of an enzyme is enhanced through catalytic activity.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Uphill production of dihydrogen by enzymatic oxidation of glucose without an external energy source

Suraniti, E., Merzeau, P., Roche, J., Gounel, S., Mark, A. G., Fischer, P., Mano, N., Kuhn, A.

Nature Communications, 9(1):3229, August 2018 (article)

Abstract
Chemical systems do not allow the coupling of energy from several simple reactions to drive a subsequent reaction, which takes place in the same medium and leads to a product with a higher energy than the one released during the first reaction. Gibbs energy considerations thus are not favorable to drive e.g., water splitting by the direct oxidation of glucose as a model reaction. Here, we show that it is nevertheless possible to carry out such an energetically uphill reaction, if the electrons released in the oxidation reaction are temporarily stored in an electromagnetic system, which is then used to raise the electrons' potential energy so that they can power the electrolysis of water in a second step. We thereby demonstrate the general concept that lower energy delivering chemical reactions can be used to enable the formation of higher energy consuming reaction products in a closed system.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Chemical micromotors self-assemble and self-propel by spontaneous symmetry breaking

Yu, T., Chuphal, P., Thakur, S., Reigh, S. Y., Singh, D. P., Fischer, P.

Chem. Comm., 54, pages: 11933-11936, August 2018 (article)

Abstract
Self-propelling chemical motors have thus far required the fabrication of Janus particles with an asymmetric catalyst distribution. Here, we demonstrate that simple, isotropic colloids can spontaneously assemble to yield dimer motors that self-propel. In a mixture of isotropic titanium dioxide colloids with photo-chemical catalytic activity and passive silica colloids, light illumination causes diffusiophoretic attractions between the active and passive particles and leads to the formation of dimers. The dimers constitute a symmetry-broken motor, whose dynamics can be fully controlled by the illumination conditions. Computer simulations reproduce the dynamics of the colloids and are in good agreement with experiments. The current work presents a simple route to obtain large numbers of self-propelling chemical motors from a dispersion of spherically symmetric colloids through spontaneous symmetry breaking.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Statistical Modelling of Fingertip Deformations and Contact Forces during Tactile Interaction

Gueorguiev, D., Tzionas, D., Pacchierotti, C., Black, M. J., Kuchenbecker, K. J.

Extended abstract presented at the Hand, Brain and Technology conference (HBT), Ascona, Switzerland, August 2018 (misc)

Abstract
Little is known about the shape and properties of the human finger during haptic interaction, even though these are essential parameters for controlling wearable finger devices and deliver realistic tactile feedback. This study explores a framework for four-dimensional scanning (3D over time) and modelling of finger-surface interactions, aiming to capture the motion and deformations of the entire finger with high resolution while simultaneously recording the interfacial forces at the contact. Preliminary results show that when the fingertip is actively pressing a rigid surface, it undergoes lateral expansion and proximal/distal bending, deformations that cannot be captured by imaging of the contact area alone. Therefore, we are currently capturing a dataset that will enable us to create a statistical model of the finger’s deformations and predict the contact forces induced by tactile interaction with objects. This technique could improve current methods for tactile rendering in wearable haptic devices, which rely on general physical modelling of the skin’s compliance, by developing an accurate model of the variations in finger properties across the human population. The availability of such a model will also enable a more realistic simulation of virtual finger behaviour in virtual reality (VR) environments, as well as the ability to accurately model a specific user’s finger from lower resolution data. It may also be relevant for inferring the physical properties of the underlying tissue from observing the surface mesh deformations, as previously shown for body tissues.

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Project Page [BibTex]

Project Page [BibTex]


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Instrumentation, Data, and Algorithms for Visually Understanding Haptic Surface Properties

Burka, A. L.

University of Pennsylvania, Philadelphia, USA, August 2018, Department of Electrical and Systems Engineering (phdthesis)

Abstract
Autonomous robots need to efficiently walk over varied surfaces and grasp diverse objects. We hypothesize that the association between how such surfaces look and how they physically feel during contact can be learned from a database of matched haptic and visual data recorded from various end-effectors' interactions with hundreds of real-world surfaces. Testing this hypothesis required the creation of a new multimodal sensing apparatus, the collection of a large multimodal dataset, and development of a machine-learning pipeline. This thesis begins by describing the design and construction of the Portable Robotic Optical/Tactile ObservatioN PACKage (PROTONPACK, or Proton for short), an untethered handheld sensing device that emulates the capabilities of the human senses of vision and touch. Its sensory modalities include RGBD vision, egomotion, contact force, and contact vibration. Three interchangeable end-effectors (a steel tooling ball, an OptoForce three-axis force sensor, and a SynTouch BioTac artificial fingertip) allow for different material properties at the contact point and provide additional tactile data. We then detail the calibration process for the motion and force sensing systems, as well as several proof-of-concept surface discrimination experiments that demonstrate the reliability of the device and the utility of the data it collects. This thesis then presents a large-scale dataset of multimodal surface interaction recordings, including 357 unique surfaces such as furniture, fabrics, outdoor fixtures, and items from several private and public material sample collections. Each surface was touched with one, two, or three end-effectors, comprising approximately one minute per end-effector of tapping and dragging at various forces and speeds. We hope that the larger community of robotics researchers will find broad applications for the published dataset. Lastly, we demonstrate an algorithm that learns to estimate haptic surface properties given visual input. Surfaces were rated on hardness, roughness, stickiness, and temperature by the human experimenter and by a pool of purely visual observers. Then we trained an algorithm to perform the same task as well as infer quantitative properties calculated from the haptic data. Overall, the task of predicting haptic properties from vision alone proved difficult for both humans and computers, but a hybrid algorithm using a deep neural network and a support vector machine achieved a correlation between expected and actual regression output between approximately ρ = 0.3 and ρ = 0.5 on previously unseen surfaces.

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Project Page [BibTex]

Project Page [BibTex]


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A machine from machines

Fischer, P.

Nature Physics, 14, pages: 1072–1073, July 2018 (misc)

Abstract
Building spinning microrotors that self-assemble and synchronize to form a gear sounds like an impossible feat. However, it has now been achieved using only a single type of building block -- a colloid that self-propels.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Chemotaxis of Active Janus Nanoparticles

Popescu, M. N., Uspal, W. E., Bechinger, C., Fischer, P.

Nano Letters, 18(9):5345–5349, July 2018 (article)

Abstract
While colloids and molecules in solution exhibit passive Brownian motion, particles that are partially covered with a catalyst, which promotes the transformation of a fuel dissolved in the solution, can actively move. These active Janus particles are known as “chemical nanomotors” or self-propelling “swimmers” and have been realized with a range of catalysts, sizes, and particle geometries. Because their active translation depends on the fuel concentration, one expects that active colloidal particles should also be able to swim toward a fuel source. Synthesizing and engineering nanoparticles with distinct chemotactic properties may enable important developments, such as particles that can autonomously swim along a pH gradient toward a tumor. Chemotaxis requires that the particles possess an active coupling of their orientation to a chemical gradient. In this Perspective we provide a simple, intuitive description of the underlying mechanisms for chemotaxis, as well as the means to analyze and classify active particles that can show positive or negative chemotaxis. The classification provides guidance for engineering a specific response and is a useful organizing framework for the quantitative analysis and modeling of chemotactic behaviors. Chemotaxis is emerging as an important focus area in the field of active colloids and promises a number of fascinating applications for nanoparticles and particle-based delivery.

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link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Programmable collective behavior in dynamically self-assembled mobile microrobotic swarms

B Yigit, , Y Alapan, , Sitti, M.

Advanced Science, July 2018 (article)

Abstract
Collective control of mobile microrobotic swarms is indispensable for their potential high-impact applications in targeted drug delivery, medical diagnostics, parallel micromanipulation, and environmental sensing and remediation. Lack of on-board computational and sensing capabilities in current microrobotic systems necessitates use of physical interactions among individual microrobots for local physical communication and cooperation. Here, we show that mobile microrobotic swarms with well-defined collective behavior can be designed by engineering magnetic interactions among individual units. Microrobots, consisting of a linear chain of self-assembled magnetic microparticles, locomote on surfaces in response to a precessing magnetic field. Control over the direction of precessing magnetic field allows engineering attractive and repulsive interactions among microrobots and, thus, collective order with well-defined spatial organization and parallel operation over macroscale distances (~ 1 cm). These microrobotic swarms can be guided through confined spaces, while preserving microrobot morphology and function. These swarms can further achieve directional transport of large cargoes on surfaces and small cargoes in bulk fluids. Described design approach, exploiting physical interactions among individual robots, enables facile and rapid formation of self-organized and reconfigurable microrobotic swarms with programmable collective order.

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link (url) [BibTex]


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3D-Printed Biodegradable Microswimmer for Drug Delivery and Targeted Cell Labeling

Hakan Ceylan, , I. Ceren Yasa, , Oncay Yasa, , Ahmet Fatih Tabak, , Joshua Giltinan, , Sitti, M.

bioRxiv, pages: 379024, July 2018 (article)

Abstract
Miniaturization of interventional medical devices can leverage minimally invasive technologies by enabling operational resolution at cellular length scales with high precision and repeatability. Untethered micron-scale mobile robots can realize this by navigating and performing in hard-to-reach, confined and delicate inner body sites. However, such a complex task requires an integrated design and engineering strategy, where powering, control, environmental sensing, medical functionality and biodegradability need to be considered altogether. The present study reports a hydrogel-based, biodegradable microrobotic swimmer, which is responsive to the changes in its microenvironment for theranostic cargo delivery and release tasks. We design a double-helical magnetic microswimmer of 20 micrometers length, which is 3D-printed with complex geometrical and compositional features. At normal physiological concentrations, matrix metalloproteinase-2 (MMP-2) enzyme can entirely degrade the microswimmer body in 118 h to solubilized non-toxic products. The microswimmer can respond to the pathological concentrations of MMP-2 by swelling and thereby accelerating the release kinetics of the drug payload. Anti-ErbB 2 antibody-tagged magnetic nanoparticles released from the degraded microswimmers serve for targeted labeling of SKBR3 breast cancer cells to realize the potential of medical imaging of local tissue sites following the therapeutic intervention. These results represent a leap forward toward clinical medical microrobots that are capable of sensing, responding to the local pathological information, and performing specific therapeutic and diagnostic tasks as orderly executed operations using their smart composite material architectures.

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DOI Project Page [BibTex]