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2019


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Semi-supervised learning, causality, and the conditional cluster assumption

von Kügelgen, J., Mey, A., Loog, M., Schölkopf, B.

NeurIPS 2019 Workshop “Do the right thing”: machine learning and causal inference for improved decision making, December 2019 (poster)

ei

link (url) [BibTex]

2019


link (url) [BibTex]


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Optimal experimental design via Bayesian optimization: active causal structure learning for Gaussian process networks

von Kügelgen, J., Rubenstein, P. K., Schölkopf, B., Weller, A.

NeurIPS 2019 Workshop “Do the right thing”: machine learning and causal inference for improved decision making, December 2019 (poster) Accepted

ei

link (url) [BibTex]

link (url) [BibTex]


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Robot Learning for Muscular Robots

Büchler, D.

Technical University Darmstadt, Germany, December 2019 (phdthesis)

ei

[BibTex]

[BibTex]


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Real Time Probabilistic Models for Robot Trajectories

Gomez-Gonzalez, S.

Technical University Darmstadt, Germany, December 2019 (phdthesis)

ei

[BibTex]

[BibTex]


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Demo Abstract: Fast Feedback Control and Coordination with Mode Changes for Wireless Cyber-Physical Systems

(Best Demo Award)

Mager, F., Baumann, D., Jacob, R., Thiele, L., Trimpe, S., Zimmerling, M.

Proceedings of the 18th ACM/IEEE Conference on Information Processing in Sensor Networks (IPSN), pages: 340-341, 18th ACM/IEEE Conference on Information Processing in Sensor Networks (IPSN), April 2019 (poster)

ics

arXiv PDF DOI [BibTex]

arXiv PDF DOI [BibTex]


Fast and Resource-Efficient Control of Wireless Cyber-Physical Systems
Fast and Resource-Efficient Control of Wireless Cyber-Physical Systems

Baumann, D.

KTH Royal Institute of Technology, Stockholm, Febuary 2019 (phdthesis)

ics

PDF [BibTex]

PDF [BibTex]


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Learning Transferable Representations

Rojas-Carulla, M.

University of Cambridge, UK, 2019 (phdthesis)

ei

[BibTex]

[BibTex]


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Sample-efficient deep reinforcement learning for continuous control

Gu, S.

University of Cambridge, UK, 2019 (phdthesis)

ei

[BibTex]


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Spatial Filtering based on Riemannian Manifold for Brain-Computer Interfacing

Xu, J.

Technical University of Munich, Germany, 2019 (mastersthesis)

ei

[BibTex]

[BibTex]


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Perception of temporal dependencies in autoregressive motion

Meding, K., Schölkopf, B., Wichmann, F. A.

European Conference on Visual Perception (ECVP), 2019 (poster)

ei

[BibTex]

[BibTex]


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Novel X-ray lenses for direct and coherent imaging

Sanli, U. T.

Universität Stuttgart, Stuttgart, 2019 (phdthesis)

mms

link (url) DOI [BibTex]

link (url) DOI [BibTex]


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Quantification of tumor heterogeneity using PET/MRI and machine learning

Katiyar, P.

Eberhard Karls Universität Tübingen, Germany, 2019 (phdthesis)

ei

[BibTex]

[BibTex]


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Phenomenal Causality and Sensory Realism

Bruijns, S. A., Meding, K., Schölkopf, B., Wichmann, F. A.

European Conference on Visual Perception (ECVP), 2019 (poster)

ei

[BibTex]

[BibTex]


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Actively Learning Dynamical Systems with Gaussian Processes

Buisson-Fenet, M.

Mines ParisTech, PSL Research University, 2019 (mastersthesis)

Abstract
Predicting the behavior of complex systems is of great importance in many fields such as engineering, economics or meteorology. The evolution of such systems often follows a certain structure, which can be induced, for example from the laws of physics or of market forces. Mathematically, this structure is often captured by differential equations. The internal functional dependencies, however, are usually unknown. Hence, using machine learning approaches that recreate this structure directly from data is a promising alternative to designing physics-based models. In particular, for high dimensional systems with nonlinear effects, this can be a challenging task. Learning dynamical systems is different from the classical machine learning tasks, such as image processing, and necessitates different tools. Indeed, dynamical systems can be actuated, often by applying torques or voltages. Hence, the user has a power of decision over the system, and can drive it to certain states by going through the dynamics. Actuating this system generates data, from which a machine learning model of the dynamics can be trained. However, gathering informative data that is representative of the whole state space remains a challenging task. The question of active learning then becomes important: which control inputs should be chosen by the user so that the data generated during an experiment is informative, and enables efficient training of the dynamics model? In this context, Gaussian processes can be a useful framework for approximating system dynamics. Indeed, they perform well on small and medium sized data sets, as opposed to most other machine learning frameworks. This is particularly important considering data is often costly to generate and process, most of all when producing it involves actuating a complex physical system. Gaussian processes also yield a notion of uncertainty, which indicates how sure the model is about its predictions. In this work, we investigate in a principled way how to actively learn dynamical systems, by selecting control inputs that generate informative data. We model the system dynamics by a Gaussian process, and use information-theoretic criteria to identify control trajectories that maximize the information gain. Thus, the input space can be explored efficiently, leading to a data-efficient training of the model. We propose several methods, investigate their theoretical properties and compare them extensively in a numerical benchmark. The final method proves to be efficient at generating informative data. Thus, it yields the lowest prediction error with the same amount of samples on most benchmark systems. We propose several variants of this method, allowing the user to trade off computations with prediction accuracy, and show it is versatile enough to take additional objectives into account.

ics

[BibTex]

[BibTex]

2016


Non-parametric Models for Structured Data and Applications to Human Bodies and Natural Scenes
Non-parametric Models for Structured Data and Applications to Human Bodies and Natural Scenes

Lehrmann, A.

ETH Zurich, July 2016 (phdthesis)

Abstract
The purpose of this thesis is the study of non-parametric models for structured data and their fields of application in computer vision. We aim at the development of context-sensitive architectures which are both expressive and efficient. Our focus is on directed graphical models, in particular Bayesian networks, where we combine the flexibility of non-parametric local distributions with the efficiency of a global topology with bounded treewidth. A bound on the treewidth is obtained by either constraining the maximum indegree of the underlying graph structure or by introducing determinism. The non-parametric distributions in the nodes of the graph are given by decision trees or kernel density estimators. The information flow implied by specific network topologies, especially the resultant (conditional) independencies, allows for a natural integration and control of contextual information. We distinguish between three different types of context: static, dynamic, and semantic. In four different approaches we propose models which exhibit varying combinations of these contextual properties and allow modeling of structured data in space, time, and hierarchies derived thereof. The generative character of the presented models enables a direct synthesis of plausible hypotheses. Extensive experiments validate the developed models in two application scenarios which are of particular interest in computer vision: human bodies and natural scenes. In the practical sections of this work we discuss both areas from different angles and show applications of our models to human pose, motion, and segmentation as well as object categorization and localization. Here, we benefit from the availability of modern datasets of unprecedented size and diversity. Comparisons to traditional approaches and state-of-the-art research on the basis of well-established evaluation criteria allows the objective assessment of our contributions.

ps

pdf [BibTex]


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Autofocusing-based correction of B0 fluctuation-induced ghosting

Loktyushin, A., Ehses, P., Schölkopf, B., Scheffler, K.

24th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM), May 2016 (poster)

ei

link (url) [BibTex]

link (url) [BibTex]


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Distinct adaptation to abrupt and gradual torque perturbations with a multi-joint exoskeleton robot

Oh, Y., Sutanto, G., Mistry, M., Schweighofer, N., Schaal, S.

Abstracts of Neural Control of Movement Conference (NCM 2016), Montego Bay, Jamaica, April 2016 (poster)

am

[BibTex]

[BibTex]


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PGO wave-triggered functional MRI: mapping the networks underlying synaptic consolidation

Logothetis, N. K., Murayama, Y., Ramirez-Villegas, J. F., Besserve, M., Evrard, H.

47th Annual Meeting of the Society for Neuroscience (Neuroscience), 2016 (poster)

ei

[BibTex]

[BibTex]


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Statistical source separation of rhythmic LFP patterns during sharp wave ripples in the macaque hippocampus

Ramirez-Villegas, J. F., Logothetis, N. K., Besserve, M.

47th Annual Meeting of the Society for Neuroscience (Neuroscience), 2016 (poster)

ei

[BibTex]

[BibTex]


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Interface-controlled phenomena in nanomaterials

Mittemeijer, Eric J.; Wang, Zumin

2016 (mpi_year_book)

Abstract
Nanosized material systems characteristically exhibit an excessively high internal interface density. A series of previously unknown phenomena in nanomaterials have been disclosed that are fundamentally caused by the presence of interfaces. Thus anomalously large and small lattice parameters in nanocrystalline metals, quantum stress oscillations in growing nanofilms, and extraordinary atomic mobility at ultralow temperatures have been observed and explained. The attained understanding for these new phenomena can lead to new, sophisticated applications of nanomaterials in advanced technologies.

link (url) [BibTex]

link (url) [BibTex]


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Hippocampal neural events predict ongoing brain-wide BOLD activity

Besserve, M., Logothetis, N. K.

47th Annual Meeting of the Society for Neuroscience (Neuroscience), 2016 (poster)

ei

[BibTex]

[BibTex]


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Robots learn how to see

Geiger, A.

2016 (mpi_year_book)

Abstract
Autonomous vehicles and intelligent service robots could soon contribute to making our lives more pleasant and secure. However, for autonomous operation such systems first need to learn the perception process itself. This involves measuring distances and motions, detecting objects and interpreting the threedimensional world as a whole. While humans perceive their environment with seemingly little efforts, computers first need to be trained for these tasks. Our research is concerned with developing mathematical models which allow computers to robustly perceive their environment.

link (url) DOI [BibTex]


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Statische und dynamische Magnetisierungseigenschaften nanoskaliger Überstrukturen

Gräfe, J.

Universität Stuttgart, Stuttgart (und Cuvillier Verlag, Göttingen), 2016 (phdthesis)

mms

[BibTex]

[BibTex]


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Gepinnte Bahnmomente in magnetischen Heterostrukturen

Audehm, P.

Universität Stuttgart, Stuttgart (und Cuvillier Verlag, Göttingen), 2016 (phdthesis)

mms

[BibTex]

[BibTex]


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Austauschgekoppelte Moden in magnetischen Vortexstrukturen

Dieterle, G.

Universität Stuttgart, Stuttgart, 2016 (phdthesis)

mms

[BibTex]

[BibTex]


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Density matrix calculations for the ultrafast demagnetization after femtosecond laser pulses

Weng, Weikai

Universität Stuttgart, Stuttgart, 2016 (mastersthesis)

mms

[BibTex]

[BibTex]


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Deep Learning for Diabetic Retinopathy Diagnostics

Balles, Lukas

Heidelberg University, 2016 (mastersthesis)

[BibTex]

[BibTex]


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Helium und Hydrogen Isotope Adsorption and Separation in Metal-Organic Frameworks

Zaiser, Ingrid

Universität Stuttgart, Stuttgart (und Cuvillier Verlag, Göttingen), 2016 (phdthesis)

mms

[BibTex]

[BibTex]

2010


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Similarities in resting state and feature-driven activity: Non-parametric evaluation of human fMRI

Shelton, J., Blaschko, M., Gretton, A., Müller, J., Fischer, E., Bartels, A.

NIPS Workshop on Learning and Planning from Batch Time Series Data, December 2010 (poster)

ei

PDF Web [BibTex]

2010


PDF Web [BibTex]


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Augmentation of fMRI Data Analysis using Resting State Activity and Semi-supervised Canonical Correlation Analysis

Shelton, JA., Blaschko, MB., Bartels, A.

NIPS Women in Machine Learning Workshop (WiML), December 2010 (poster)

Abstract
Resting state activity is brain activation that arises in the absence of any task, and is usually measured in awake subjects during prolonged fMRI scanning sessions where the only instruction given is to close the eyes and do nothing. It has been recognized in recent years that resting state activity is implicated in a wide variety of brain function. While certain networks of brain areas have different levels of activation at rest and during a task, there is nevertheless significant similarity between activations in the two cases. This suggests that recordings of resting state activity can be used as a source of unlabeled data to augment kernel canonical correlation analysis (KCCA) in a semisupervised setting. We evaluate this setting empirically yielding three main results: (i) KCCA tends to be improved by the use of Laplacian regularization even when no additional unlabeled data are available, (ii) resting state data seem to have a similar marginal distribution to that recorded during the execution of a visual processing task implying largely similar types of activation, and (iii) this source of information can be broadly exploited to improve the robustness of empirical inference in fMRI studies, an inherently data poor domain.

ei

PDF Web [BibTex]

PDF Web [BibTex]


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High frequency phase-spike synchronization of extracellular signals modulates causal interactions in monkey primary visual cortex

Besserve, M., Murayama, Y., Schölkopf, B., Logothetis, N., Panzeri, S.

40(616.2), 40th Annual Meeting of the Society for Neuroscience (Neuroscience), November 2010 (poster)

Abstract
Functional correlates of Rhythms in the gamma band (30-100Hz) are observed in the mammalian brain with a large variety of functional correlates. Nevertheless, their functional role is still debated. One way to disentangle this issue is to go beyond usual correlation analysis and apply causality measures that quantify the directed interactions between the gamma rhythms and other aspects of neural activity. These measures can be further compared with other aspects of neurophysicological signals to find markers of neural interactions. In a recent study, we analyzed extracellular recordings in the primary visual cortex of 4 anesthetized macaques during the presentation of movie stimuli using a causality measure named Transfer Entropy. We found causal interactions between high frequency gamma rhythms (60-100Hz) recorded in different electrodes, involving in particular their phase, and between the gamma phase and spiking activity quantified by the instantaneous envelope of the MUA band (1-3kHz). Here, we further investigate in the same dataset the meaning of these phase-MUA and phase-phase causal interactions by studying the distribution of phases at multiple recording sites at lags around the occurrence of spiking events. First, we found a sharpening of the gamma phase distribution in one electrode when spikes are occurring in other recording site. This phenomena appeared as a form of phase-spike synchronization and was quantified by an information theoretic measure. We found this measure correlates significantly with phase-MUA causal interactions. Additionally, we quantified in a similar way the interplay between spiking and the phase difference between two recording sites (reflecting the well-know concept of phase synchronization). We found that, depending on the couple of recording site, spiking can correlate either with a phase synchronization or with a desynchronization with respect to the baseline. This effect correlates very well with the phase-phase causality measure. These results provide evidence for high frequency phase-spike synchronization to reflect communication between distant neural populations in V1. Conversely, both phase synchronization or desynchronization may favor neural communication between recording sites. This new result, which contrasts with current hypothesis on the role of phase synchronization, could be interpreted as the presence of inhibitory interactions that are suppressed by desynchronization. Finally, our findings give new insights into the role of gamma rhythms in regulating local computation in the visual cortex.

ei

Web [BibTex]

Web [BibTex]


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Attenuation Correction for Whole Body PET/MR: Quantitative Evaluation and Lung Attenuation Estimation with Consistency Information

Bezrukov, I., Hofmann, M., Aschoff, P., Beyer, T., Mantlik, F., Pichler, B., Schölkopf, B.

2010(M13-122), 2010 Nuclear Science Symposium and Medical Imaging Conference (NSS-MIC), November 2010 (poster)

ei

[BibTex]

[BibTex]


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PET/MRI: Observation of Non-Isotropic Positron Distribution in High Magnetic Fields and Its Diagnostic Impact

Kolb, A., Hofmann, M., Sauter, A., Liu, C., Schölkopf, B., Pichler, B.

2010 Nuclear Science Symposium and Medical Imaging Conference, 2010(M18-119):1, November 2010 (poster)

ei

Web [BibTex]

Web [BibTex]


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Probabilistic Assignment of Chemical Shift Data for Semi-Automatic Amino Acid Recognition

Hooge, J.

11(10):30, 11th Conference of Junior Neuroscientists of T{\"u}bingen (NeNa), October 2010 (poster)

Abstract
manner. First the backbone resonances are assigned. This is usually achieved from sequential information provided by three chemical shifts: CA, CB and C’. Once the sequence is solved, the second assignment step takes place. For this purpose, the CA-CB and HA chemical shifts are used as a start point for assignment of the side chain resonances, thus connecting the backbone resonances to their respective side chains. This strategy is unfortunately limited by the size of the protein due to increasing signal overlap and missing signals. Therefore, amino acid recognition is in many cases not possible as the CA-CB chemical shift pattern is not sufficient to discriminate between the 20 amino acids. As a result, the first step of the strategy described above remains tedious and time consuming. The combination of modern NMR techniques with new spectrometers now provide information that was not always accessible in the past, due to sensitivity problems. These experiments can be applied efficiently to measure a protein size up to 45 kDa and furthermore provide a unique combination of sequential carbon spin system information. The assignment process can thus benefit from a maximum knowledge input, containing âallâ backbone and side chain chemical shifts as well as an immediate amino acid recognition from the side chain spin system. We propose to extend the software PASTA (Protein ASsignment by Threshold Accepting) to achieve a general sequential assignment of backbone and side-chain resonances in a semi- to fullautomatic per-residue approach. PASTA will offer the possibility to achieve the sequential assignment using any kind of chemical shifts (carbons and/or protons) that can provide sequential information combined with an amino acid recognition feature based on carbon spin system analysis.

ei

PDF [BibTex]

PDF [BibTex]


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Generalizing Demonstrated Actions in Manipulation Tasks

Kroemer, O., Detry, R., Piater, J., Peters, J.

IROS 2010 Workshop on Grasp Planning and Task Learning by Imitation, 2010, pages: 1, October 2010 (poster)

Abstract
Programming-by-demonstration promises to significantly reduce the burden of coding robots to perform new tasks. However, service robots will be presented with a variety of different situations that were not specifically demonstrated to it. In such cases, the robot must autonomously generalize its learned motions to these new situations. We propose a system that can generalize movements to new target locations and even new objects. The former is achieved by using a task-specific coordinate system together with dynamical systems motor primitives. Generalizing actions to new objects is a more complex problem, which we solve by treating it as a continuum-armed bandits problem. Using the bandits framework, we can efficiently optimize the learned action for a specific object. The proposed method was implemented on a real robot and succesfully adapted the grasping action to three different objects. Although we focus on grasping as an example of a task, the proposed methods are much more widely applicable to robot manipulation tasks.

ei

PDF Web [BibTex]

PDF Web [BibTex]


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Bayesian Inference and Experimental Design for Large Generalised Linear Models

Nickisch, H.

Biologische Kybernetik, Technische Universität Berlin, Berlin, Germany, September 2010 (phdthesis)

ei

PDF Web [BibTex]

PDF Web [BibTex]


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Inhomogeneous Positron Range Effects in High Magnetic Fields might Cause Severe Artefacts in PET/MRI

Kolb, A., Hofmann, M., Sauter, A., Liu, C., Eriksson, L., Pichler, B.

(0305B), 2010 World Molecular Imaging Congress (WMIC), September 2010 (poster)

Abstract
The combination of PET and MRI is an emerging field of current research. It is known that the positron range is shortened in high magnetic fields (MF), leading to an improved resolution in PET images. Interestingly, only the fraction of positron range (PR) orthogonal to the MF is reduced and the fraction along the MF is not affected and yields to a non-isotropic count distribution. We measured the PR effect with PET isotopes like F-18, Cu-64, C-11, N-13 and Ga-68. A piece of paper (1 cm2) was soaked with each isotope and placed in the cFOV of a clinical 3T BrainPET/MR scanner. A polyethylene board (PE) was placed as a positron (β+) stopper with an axial distance of 3 cm from the soaked paper. The area under the peaks of one pixel wide profiles along the z-axis in coronal images was compared. Based on these measurements we confirmed our data in organic tissue. A larynx/trachea and lung of a butchered swine were injected with a mixture of NiSO4 for T1 MRI signals and Ga-68, simulating tumor lesions in the respiratory tract. The trachea/larynx were aligned in 35° to the MF lines and a small mass lesion was inserted to imitate a primary tracheal tumor whereas the larynx was injected submucosally in the lower medial part of the epiglottis. Reconstructed PET data show that the annihilated ratio of β+ at the origin position and in the PE depends on the isotope energy and the direction of the MF. The annihilation ratios of the source and PE are 52.4/47.6 (F-18), 57.5/42.5 (Cu-64), 43.7/56.7 (C-11), 31.1/68.9 (N-13) and 14.9/85.1 (Ga-68). In the swine larynx measurement, an artefact with approximately 39% of the lesion activity formed along MF lines 3cm away from the original injected position (fig.1). The data of the trachea showed two shine artefacts with a symmetric alignment along the MF lines. About 58% of the positrons annihilated at the lesion and 21% formed each artefact. The PR effects areminor in tissue of higher or equal density to water (0.096 cm-1). However, the effect is severe in low density tissue or air and might lead to misinterpretation of clinical data.

ei

Web [BibTex]

Web [BibTex]


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Inferring High-Dimensional Causal Relations using Free Probability Theory

Zscheischler, J.

Humboldt Universität Berlin, Germany, August 2010 (diplomathesis)

ei

PDF [BibTex]

PDF [BibTex]


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Reinforcement Learning by Relative Entropy Policy Search

Peters, J., Mülling, K., Altun, Y.

30th International Workshop on Bayesian Inference and Maximum Entropy Methods in Science and Engineering (MaxEnt 2010), 30, pages: 69, July 2010 (poster)

Abstract
Policy search is a successful approach to reinforcement learning. However, policy improvements often result in the loss of information. Hence, it has been marred by premature convergence and implausible solutions. As first suggested in the context of covariant policy gradients, many of these problems may be addressed by constraining the information loss. In this book chapter, we continue this path of reasoning and suggest the Relative Entropy Policy Search (REPS) method. The resulting method differs significantly from previous policy gradient approaches and yields an exact update step. It works well on typical reinforcement learning benchmark problems. We will also present a real-world applications where a robot employs REPS to learn how to return balls in a game of table tennis.

ei

PDF [BibTex]

PDF [BibTex]


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Semi-supervised Subspace Learning and Application to Human Functional Magnetic Brain Resonance Imaging Data

Shelton, J.

Biologische Kybernetik, Eberhard Karls Universität, Tübingen, Germany, July 2010 (diplomathesis)

ei

PDF [BibTex]

PDF [BibTex]


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A Maximum Entropy Approach to Semi-supervised Learning

Erkan, A., Altun, Y.

30th International Workshop on Bayesian Inference and Maximum Entropy Methods in Science and Engineering (MaxEnt 2010), 30, pages: 80, July 2010 (poster)

Abstract
Maximum entropy (MaxEnt) framework has been studied extensively in supervised learning. Here, the goal is to find a distribution p that maximizes an entropy function while enforcing data constraints so that the expected values of some (pre-defined) features with respect to p match their empirical counterparts approximately. Using different entropy measures, different model spaces for p and different approximation criteria for the data constraints yields a family of discriminative supervised learning methods (e.g., logistic regression, conditional random fields, least squares and boosting). This framework is known as the generalized maximum entropy framework. Semi-supervised learning (SSL) has emerged in the last decade as a promising field that combines unlabeled data along with labeled data so as to increase the accuracy and robustness of inference algorithms. However, most SSL algorithms to date have had trade-offs, e.g., in terms of scalability or applicability to multi-categorical data. We extend the generalized MaxEnt framework to develop a family of novel SSL algorithms. Extensive empirical evaluation on benchmark data sets that are widely used in the literature demonstrates the validity and competitiveness of the proposed algorithms.

ei

PDF PDF [BibTex]

PDF PDF [BibTex]


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The effect of positioning aids on PET quantification following MR-based attenuation correction (AC) in PET/MR imaging

Mantlik, F., Hofmann, M., Kupferschläger, J., Werner, M., Pichler, B., Beyer, T.

Journal of Nuclear Medicine, 51(Supplement 2):1418 , June 2010 (poster)

Abstract
Objectives: We study the quantitative effect of not accounting for the attenuation of patient positioning aids in combined PET/MR imaging. Methods: Positioning aids cannot be detected with conventional MR sequences. We mimic this effect using PET/CT data (Biograph HiRez16) with the foams removed from CT images prior to using them for CT-AC. PET/CT data were acquired using standard parameters (phantoms/patients): 120/140 kVp, 30/250 mAs, 5 mm slices, OSEM (4i, 8s, 5 mm filter) following CT-AC. First, a uniform 68Ge-cylinder was positioned centrally in the PET/CT and fixed with a vacuum mattress (10 cm thick). Second, the same cylinder was placed in 3 positioning aids from the PET/MR (BrainPET-3T). Third, 5 head/neck patients who were fixed in a vacuum mattress were selected. In all 3 studies PET recon post CT-AC based on measured CT images was used as the reference (mCT-AC). The PET/MR set-up was mimicked by segmenting the foam inserts from the measured CT images and setting their voxel values to -1000 HU (air). PET images were reconstructed using CT-AC with the segmented CT images (sCT-AC). PET images with mCT- and sCT-AC were compared. Results: sCT-AC underestimated PET voxel values in the phantom by 6.7% on average compared to mCT-AC with the vacuum mattress in place. 5% of the PET voxels were underestimated by >=10%. Not accounting for MR positioning aids during AC led to an underestimation of 2.8% following sCT-AC, with 5% of the PET voxels being underestimated by >=7% wrt mCT-AC. Preliminary evaluation of the patient data indicates a slightly higher bias from not accounting for patient positioning aids (mean: -9.1%, 5% percentile: -11.2%). Conclusions: A considerable and regionally variable underestimation of the PET activity following AC is observed when positioning aids are not accounted for. This bias may become relevant in neurological activation or dementia studies with PET/MR

ei

Web [BibTex]

Web [BibTex]


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Multi-task Learning for Zero Training Brain-Computer Interfaces

Alamgir, M., Grosse-Wentrup, M., Altun, Y.

4th International BCI Meeting, June 2010 (poster)

Abstract
Brain-computer interfaces (BCIs) are limited in their applicability in everyday settings by the current necessity to record subject-specific calibration data prior to actual use of the BCI for communication. In this work, we utilize the framework of multitask learning to construct a BCI that can be used without any subject-specific calibration process, i.e., with zero training data. In BCIs based on EEG or MEG, the predictive function of a subject's intention is commonly modeled as a linear combination of some features derived from spatial and spectral recordings. The coefficients of this combination correspond to the importance of the features for predicting the intention of the subject. These coefficients are usually learned separately for each subject due to inter-subject variability. Principle feature characteristics, however, are known to remain invariant across subject. For example, it is well known that in motor imagery paradigms spectral power in the mu- and beta frequency ranges (roughly 8-14 Hz and 20-30 Hz, respectively) over sensorimotor areas provides most information on a subject's intention. Based on this assumption, we define the intention prediction function as a combination of subject-invariant and subject-specific models, and propose a machine learning method that infers these models jointly using data from multiple subjects. This framework leads to an out-of-the-box intention predictor, where the subject-invariant model can be employed immediately for a subject with no prior data. We present a computationally efficient method to further improve this BCI to incorporate subject-specific variations as such data becomes available. To overcome the problem of high dimensional feature spaces in this context, we further present a new method for finding the relevance of different recording channels according to actions performed by subjects. Usually, the BCI feature representation is a concatenation of spectral features extracted from different channels. This representation, however, is redundant, as recording channels at different spatial locations typically measure overlapping sources within the brain due to volume conduction. We address this problem by assuming that the relevance of different spectral bands is invariant across channels, while learning different weights for each recording electrode. This framework allows us to significantly reduce the feature space dimensionality without discarding potentially useful information. Furthermore, the resulting out-of-the-box BCI can be adapted to different experimental setups, for example EEG caps with different numbers of channels, as long as there exists a mapping across channels in different setups. We demonstrate the feasibility of our approach on a set of experimental EEG data recorded during a standard two-class motor imagery paradigm from a total of ten healthy subjects. Specifically, we show that satisfactory classification results can be achieved with zero training data, and that combining prior recordings with subject-specific calibration data substantially outperforms using subject-specific data only.

ei

Web [BibTex]